Protein: O00308

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O00308 (Uniprot) WWP2_HUMAN WWP2 NEDD4-like E3 ubiquitin-protein ligase WWP2 human No
Uniprot: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 48 GO:0009059 macromolecule biosynthetic process 93 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
48 GO:0044248 cellular catabolic process
48 GO:0070647 protein modification by small protein conjugation or removal
48 GO:0006508 proteolysis
48 GO:0060255 regulation of macromolecule metabolic process
48 GO:0007165 signal transduction
64 GO:0016070 RNA metabolic process
64 GO:0010467 gene expression
64 GO:0060255 regulation of macromolecule metabolic process
93 GO:0034645 cellular macromolecule biosynthetic process
93 GO:0034654 nucleobase-containing compound biosynthetic process
93 GO:0019538 protein metabolic process
93 GO:0051252 regulation of RNA metabolic process
93 GO:0010468 regulation of gene expression
189 GO:0090304 nucleic acid metabolic process
191 GO:0006355 regulation of transcription, DNA-templated
204 GO:0044267 cellular protein metabolic process
420 GO:0006464 cellular protein modification process
656 GO:0016070 RNA metabolic process
656 GO:0034645 cellular macromolecule biosynthetic process
656 GO:0044271 cellular nitrogen compound biosynthetic process
656 GO:0010467 gene expression
656 GO:0060255 regulation of macromolecule metabolic process
692 GO:0016070 RNA metabolic process
692 GO:0044271 cellular nitrogen compound biosynthetic process
692 GO:0010467 gene expression
692 GO:0019538 protein metabolic process
692 GO:2000112 regulation of cellular macromolecule biosynthetic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
48 GO:0031410 cytoplasmic vesicle
48 GO:0012505 endomembrane system
48 GO:0005634 nucleus
48 GO:0005886 plasma membrane
64 GO:0005634 nucleus
93 GO:0005829 cytosol
93 GO:0005634 nucleus
189 GO:0005634 nucleus
191 GO:0031981 nuclear lumen
204 GO:0005634 nucleus
420 GO:0005829 cytosol
420 GO:0005634 nucleus
656 GO:0043232 intracellular non-membrane-bounded organelle
656 GO:0005634 nucleus
692 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0006366 transcription from RNA polymerase II promoter IEA
GO:0006464 cellular protein modification process TAS
GO:0006858 extracellular transport IMP
GO:0010629 negative regulation of gene expression IMP
GO:0016567 protein ubiquitination IDA
GO:0032410 negative regulation of transporter activity IDA
GO:0034765 regulation of ion transmembrane transport IDA
GO:0042391 regulation of membrane potential IDA
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
GO:0043433 negative regulation of DNA binding transcription factor activity ISS
GO:0045892 negative regulation of transcription, DNA-templated ISS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA
GO:0046718 viral entry into host cell TAS
GO:0051224 negative regulation of protein transport IMP
GO:0051865 protein autoubiquitination IDA
GO:0070534 protein K63-linked ubiquitination IBA
GO:1901016 regulation of potassium ion transmembrane transporter activity IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000151 ubiquitin ligase complex TAS
GO:0005634 nucleus IDA
GO:0005737 cytoplasm ISS
GO:0005829 cytosol TAS
GO:0016020 membrane IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000151 ubiquitin ligase complex GO:0016020 membrane 6.01e-29 2.12e-49
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
PMID Article Title
9169421 Identification of novel human WW domain-containing proteins by cloning of ligand targets.
9647693 Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
11748237 N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.
12167593 Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.
12450395 Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15616553 The sequence and analysis of duplication-rich human chromosome 16.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17719543 Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.
19274063 WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells.
19343052 Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.
19651900 The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination.
20858735 Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.
21191027 Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21572392 SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.
22315426 Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23236378 Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with beta arrestins.
26457515 Structure of the HECT domain of human WWP2.
No results found.
Domain Name Domain ID Source
C2_dom IPR000008 InterPro
HECT_dom IPR000569 InterPro
WW_dom IPR001202 InterPro
E3_ub_ligase_SMURF1 IPR024928 InterPro
C2_domain_sf IPR035892 InterPro
Hect_E3_ubiquitin_ligase IPR035983 InterPro
WW_dom_sf IPR036020 InterPro
WW PF00397 Pfam
HECT PF00632 Pfam
E3_ub_ligase_SMURF1 PIRSF001569 PIRSF
WW_DOMAIN_1 PS01159 PROSITE
WW_DOMAIN_2 PS50020 PROSITE
HECT PS50237 PROSITE
HECTc SM00119 SMART
C2 SM00239 SMART
WW SM00456 SMART
SSF49562 SSF49562 SUPFAM
SSF51045 SSF51045 SUPFAM
SSF56204 SSF56204 SUPFAM
HECTc cd00078 CDD
WW cd00201 CDD