Protein: A5D8V6 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
A5D8V6 (Uniprot)	VP37C_HUMAN	VPS37C	Vacuolar protein sorting-associated protein 37C	human	No

Protein Function

Uniprot: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	153	GO:0007165	signal transduction	355	1.10e-111	5.07e-25

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 27 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
64	GO:0016070	RNA metabolic process
64	GO:0010467	gene expression
64	GO:0060255	regulation of macromolecule metabolic process
153	GO:0090304	nucleic acid metabolic process
153	GO:0060255	regulation of macromolecule metabolic process
191	GO:0006355	regulation of transcription, DNA-templated
355	GO:0007166	cell surface receptor signaling pathway
355	GO:0006464	cellular protein modification process
355	GO:0035556	intracellular signal transduction
355	GO:0016310	phosphorylation

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Cellular Components

Showing 1 to 10 of 12 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
60	GO:0005634	nucleus
64	GO:0005634	nucleus
153	GO:0005634	nucleus
191	GO:0031981	nuclear lumen
298	GO:0015630	microtubule cytoskeleton
355	GO:0044459	plasma membrane part
403	GO:0005634	nucleus
450	GO:0005634	nucleus
552	GO:0005634	nucleus
620	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

Showing 1 to 7 of 7 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0015031	protein transport	IEA
GO:0016197	endosomal transport	TAS
GO:0016236	macroautophagy	TAS
GO:0019058	viral life cycle	TAS
GO:0036258	multivesicular body assembly	TAS
GO:0039702	viral budding via host ESCRT complex	TAS
GO:0075733	intracellular transport of virus	TAS

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000813	ESCRT I complex	IDA
GO:0010008	endosome membrane	TAS
GO:0031902	late endosome membrane	IEA
GO:0043657	host cell	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 91 entries

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Interactor	Also a MoonDB EMF protein
A0A087WSW0_HUMAN	No
AARD_HUMAN	No
ABHDB_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
AP2D_HUMAN	No
ASCL3_HUMAN	No
BAAS2_HUMAN	No
BAG4_HUMAN	No
BIRC7_HUMAN	No
CA094_HUMAN	No

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Publications Associated

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PMID	Article Title
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15509564	Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.
16554811	Human chromosome 11 DNA sequence and analysis including novel gene identification.
17853893	Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
17974005	The full-ORF clone resource of the German cDNA consortium.
18005716	Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.
21269460	Initial characterization of the human central proteome.
21270402	TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.
22405001	The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 6 of 6 entries

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Domain Name	Domain ID	Source
ESCRT_assembly_dom	IPR037202	InterPro
HLH_DNA-bd_sf	IPR036638	InterPro
Mod_r	IPR009851	InterPro
Mod_r	PF07200	Pfam
SSF140111	SSF140111	SUPFAM
VPS37_C	PS51314	PROSITE

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