Protein: Q8WZ42 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8WZ42 (Uniprot)	TITIN_HUMAN	TTN	Titin	human	No

Protein Function

Uniprot: Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcome more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	306, 376	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
25	GO:0006464	cellular protein modification process
25	GO:0010467	gene expression
25	GO:0060255	regulation of macromolecule metabolic process
25	GO:0007165	signal transduction
77	GO:0007165	signal transduction
144	GO:0009059	macromolecule biosynthetic process
144	GO:0090304	nucleic acid metabolic process
189	GO:0090304	nucleic acid metabolic process
191	GO:0006355	regulation of transcription, DNA-templated
225	GO:0016070	RNA metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
25	GO:0005829	cytosol
25	GO:0005634	nucleus
30	GO:0005829	cytosol
30	GO:0043232	intracellular non-membrane-bounded organelle
77	GO:0070013	intracellular organelle lumen
77	GO:0005634	nucleus
144	GO:0043232	intracellular non-membrane-bounded organelle
144	GO:0031981	nuclear lumen
189	GO:0005634	nucleus
191	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002576	platelet degranulation	TAS
GO:0003300	cardiac muscle hypertrophy	IMP
GO:0006936	muscle contraction	TAS
GO:0006941	striated muscle contraction	TAS
GO:0007076	mitotic chromosome condensation	IEP
GO:0010628	positive regulation of gene expression	IMP
GO:0010737	protein kinase A signaling	IMP
GO:0018108	peptidyl-tyrosine phosphorylation	IEA
GO:0030049	muscle filament sliding	TAS
GO:0030240	skeletal muscle thin filament assembly	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000794	condensed nuclear chromosome	IDA
GO:0005576	extracellular region	TAS
GO:0005829	cytosol	TAS
GO:0005859	muscle myosin complex	IBA
GO:0030018	Z disc	IDA
GO:0031430	M band	IBA
GO:0031674	I band	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABLM1_HUMAN	No
ABLM2_HUMAN	No
ACTN1_HUMAN	No
ACTN2_HUMAN	No
ACTN3_HUMAN	No
ACTN4_HUMAN	No
AMOT_HUMAN	No
ANK1_HUMAN	No
ANKR1_HUMAN	No
ANR23_HUMAN	No

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Publications Associated

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PMID	Article Title
1582406	Towards a molecular understanding of titin.
7569978	Titins, giant proteins in charge of muscle ultrastructure and elasticity.
7613868	Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set.
7819249	Dissecting titin into its structural motifs: identification of an alpha helix near the N-terminus.
8351016	Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin.
8404852	Phosphorylation of KSF motifs in the C-terminal region of titin in differentiating myoblasts.
8937992	The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers.
9645487	Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin.
9782056	The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains.
9804419	Structural basis for activation of the titin kinase domain during myofibrillogenesis.

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OMIM Diseases Associated

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OMIM ID	Disease Name
600334	Tardive tibial muscular dystrophy
603689	Hereditary myopathy with early respiratory failure
604145	Cardiomyopathy, dilated 1G
608807	Limb-girdle muscular dystrophy 2J
611705	Salih myopathy

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Protein Domains Associated

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Domain Name	Domain ID	Source
fn3	PF00041	Pfam
FN3	PS50853	PROSITE
FN3	SM00060	SMART
FN3	cd00063	CDD
FN3_dom	IPR003961	InterPro
FN3_sf	IPR036116	InterPro
I-set	PF07679	Pfam
I38344	I38344	PIR
I38346	I38346	PIR
IG	SM00409	SMART

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