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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P52735
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P52735 (Uniprot)
VAV2_HUMAN
VAV2
Guanine nucleotide exchange factor VAV2
human
No
Protein Function
Uniprot:
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
MoonDB Dissimilar Functions
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0019538
protein metabolic process
166
,
181
,
215
,
376
GO:0000377
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
467
1.88e-02
4.66e-37
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 50 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
37
GO:0007165
signal transduction
111
GO:0006955
immune response
111
GO:0035556
intracellular signal transduction
111
GO:0009967
positive regulation of signal transduction
111
GO:0006468
protein phosphorylation
111
GO:0060255
regulation of macromolecule metabolic process
111
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
166
GO:0044267
cellular protein metabolic process
166
GO:0006139
nucleobase-containing compound metabolic process
166
GO:0060255
regulation of macromolecule metabolic process
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Cellular Components
Showing 1 to 10 of 33 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
37
GO:0005829
cytosol
43
GO:0005634
nucleus
111
GO:0005829
cytosol
111
GO:0005886
plasma membrane
166
GO:0005829
cytosol
166
GO:0070013
intracellular organelle lumen
166
GO:0044428
nuclear part
166
GO:0005886
plasma membrane
167
GO:0005654
nucleoplasm
181
GO:0005829
cytosol
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 19 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0001525
angiogenesis
IEA
GO:0007165
signal transduction
TAS
GO:0007186
G-protein coupled receptor signaling pathway
TAS
GO:0007264
small GTPase mediated signal transduction
IEA
GO:0008361
regulation of cell size
IGI
GO:0010468
regulation of gene expression
IMP
GO:0016477
cell migration
IEA
GO:0030032
lamellipodium assembly
IEA
GO:0030168
platelet activation
TAS
GO:0030193
regulation of blood coagulation
IMP
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005829
cytosol
TAS
GO:0005886
plasma membrane
IEA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 55 entries
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Interactor
Also a MoonDB EMF protein
3BP2_HUMAN
No
ANDR_HUMAN
Yes:
P10275 (MoonDB)
ARI1_HUMAN
No
BD1L1_HUMAN
No
BIRC6_HUMAN
No
BRDT_HUMAN
No
BZW1_HUMAN
No
CBLB_HUMAN
No
CCNO_HUMAN
No
CE170_HUMAN
No
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Publications Associated
Showing 1 to 10 of 15 entries
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PMID
Article Title
7762982
Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.
12454019
Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.
15164053
DNA sequence and analysis of human chromosome 9.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15561106
The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
15618286
Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.
16964243
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17974005
The full-ORF clone resource of the German cDNA consortium.
18669648
A quantitative atlas of mitotic phosphorylation.
18691976
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 50 entries
Search:
Domain Name
Domain ID
Source
C1
SM00109
SMART
C1
cd00029
CDD
C1_1
PF00130
Pfam
Calponin-like_dom_sf
IPR036872
InterPro
CAMSAP_CH
IPR022613
InterPro
CAMSAP_CH
PF11971
Pfam
CH
PS50021
PROSITE
CH
SM00033
SMART
CH
cd00014
CDD
CH-domain
IPR001715
InterPro
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