Protein: O75674

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O75674 (Uniprot) TM1L1_HUMAN TOM1L1 TOM1-like protein 1 human No
Uniprot: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 531 GO:0051641 cellular localization 872 4.90e-06 1.31e-91
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
37 GO:0007165 signal transduction
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
145 GO:0060255 regulation of macromolecule metabolic process
166 GO:0044267 cellular protein metabolic process
166 GO:0006139 nucleobase-containing compound metabolic process
166 GO:0060255 regulation of macromolecule metabolic process
166 GO:0007165 signal transduction
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
419 GO:0022607 cellular component assembly
531 GO:0019538 protein metabolic process
872 GO:0051649 establishment of localization in cell
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
37 GO:0005829 cytosol
134 GO:0005829 cytosol
134 GO:0005634 nucleus
140 GO:0043232 intracellular non-membrane-bounded organelle
145 GO:0070013 intracellular organelle lumen
145 GO:0044428 nuclear part
166 GO:0005829 cytosol
166 GO:0070013 intracellular organelle lumen
166 GO:0044428 nuclear part
166 GO:0005886 plasma membrane
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
872 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006886 intracellular protein transport IEA
GO:0007165 signal transduction IDA
GO:0031954 positive regulation of protein autophosphorylation IDA
GO:0032147 activation of protein kinase activity IDA
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway NAS
GO:0045839 negative regulation of mitotic nuclear division IDA
GO:2000278 regulation of DNA biosynthetic process IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
GO:0005764 lysosome TAS
GO:0005768 endosome IDA
GO:0005795 Golgi stack IEA
GO:0005829 cytosol IDA
GO:0010008 endosome membrane IEA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10329004 TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
VHS_dom IPR002014 InterPro
GAT_dom IPR004152 InterPro
ENTH_VHS IPR008942 InterPro
TOM1 IPR014645 InterPro
TOM1L1 IPR027428 InterPro
VHS PF00790 Pfam
GAT PF03127 Pfam
TOM1 PIRSF036948 PIRSF
VHS PS50179 PROSITE
GAT PS50909 PROSITE
PTHR13856:SF28 PTHR13856:SF28 PANTHER
VHS SM00288 SMART
SSF48464 SSF48464 SUPFAM