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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P42684
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P42684 (Uniprot)
ABL2_HUMAN
ABL2
Abelson tyrosine-protein kinase 2
human
No
Protein Function
Uniprot:
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of p
roteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0007165
signal transduction
187
GO:0034641
cellular nitrogen compound metabolic process
327
4.22e-144
6.90e-18
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 28 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
186
GO:0048468
cell development
186
GO:0007166
cell surface receptor signaling pathway
186
GO:0044267
cellular protein metabolic process
186
GO:0035556
intracellular signal transduction
186
GO:0030182
neuron differentiation
186
GO:0006796
phosphate-containing compound metabolic process
186
GO:0120036
plasma membrane bounded cell projection organization
186
GO:0060255
regulation of macromolecule metabolic process
186
GO:0009966
regulation of signal transduction
187
GO:0007166
cell surface receptor signaling pathway
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Cellular Components
Showing 1 to 10 of 10 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
186
GO:0005829
cytosol
186
GO:0005886
plasma membrane
186
GO:0031982
vesicle
187
GO:0005829
cytosol
187
GO:0005886
plasma membrane
259
GO:0005886
plasma membrane
327
GO:0005829
cytosol
327
GO:0043232
intracellular non-membrane-bounded organelle
327
GO:0005634
nucleus
327
GO:0005886
plasma membrane
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 18 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006464
cellular protein modification process
TAS
GO:0007155
cell adhesion
IEA
GO:0007165
signal transduction
TAS
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
IBA
GO:0007204
positive regulation of cytosolic calcium ion concentration
IMP
GO:0010506
regulation of autophagy
TAS
GO:0010863
positive regulation of phospholipase C activity
IMP
GO:0010976
positive regulation of neuron projection development
IMP
GO:0018108
peptidyl-tyrosine phosphorylation
IDA
GO:0030100
regulation of endocytosis
TAS
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Cellular Components
Showing 1 to 3 of 3 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005829
cytosol
TAS
GO:0015629
actin cytoskeleton
TAS
GO:0031234
extrinsic component of cytoplasmic side of plasma membrane
IBA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 30 entries
Search:
Interactor
Also a MoonDB EMF protein
ABI2_HUMAN
Yes:
Q9NYB9 (MoonDB)
ANDR_HUMAN
Yes:
P10275 (MoonDB)
CIP4_HUMAN
No
CRK_HUMAN
Yes:
P46108 (MoonDB)
EGFR_HUMAN
Yes:
P00533 (MoonDB)
EPHB2_HUMAN
No
ERBB2_HUMAN
Yes:
P04626 (MoonDB)
ERBB3_HUMAN
Yes:
P21860 (MoonDB)
ERBB4_HUMAN
No
FBX38_HUMAN
No
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Publications Associated
Showing 1 to 10 of 32 entries
Search:
PMID
Article Title
2198571
The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.
3787260
A novel human gene closely related to the abl proto-oncogene.
12748290
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
12775773
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
14729179
How do Abl family kinases regulate cell shape and movement?
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15735735
Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.
15886098
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
16678104
Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 33 entries
Search:
Domain Name
Domain ID
Source
A35962
A35962
PIR
ABL_SH2
IPR035837
InterPro
B35962
B35962
PIR
F-actin_binding
IPR015015
InterPro
F_actin_bind
PF08919
Pfam
FABD
SM00808
SMART
Kinase-like_dom_sf
IPR011009
InterPro
Pkinase_Tyr
PF07714
Pfam
Prot_kinase_dom
IPR000719
InterPro
PROTEIN_KINASE_ATP
PS00107
PROSITE
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