Protein: Q8TAD8

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8TAD8 (Uniprot) SNIP1_HUMAN SNIP1 Smad nuclear-interacting protein 1 human No
Uniprot: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 194 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 353 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
47 GO:0044271 cellular nitrogen compound biosynthetic process
47 GO:0051252 regulation of RNA metabolic process
47 GO:0010468 regulation of gene expression
194 GO:0044267 cellular protein metabolic process
194 GO:0006355 regulation of transcription, DNA-templated
353 GO:0000398 mRNA splicing, via spliceosome
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
413 GO:0044267 cellular protein metabolic process
413 GO:0031326 regulation of cellular biosynthetic process
413 GO:0010468 regulation of gene expression
413 GO:0010556 regulation of macromolecule biosynthetic process
413 GO:0007165 signal transduction
413 GO:0006351 transcription, DNA-templated
720 GO:0006464 cellular protein modification process
720 GO:0071310 cellular response to organic substance
720 GO:0006355 regulation of transcription, DNA-templated
720 GO:0006366 transcription from RNA polymerase II promoter
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
47 GO:0005654 nucleoplasm
91 GO:0005576 extracellular region
194 GO:0043232 intracellular non-membrane-bounded organelle
194 GO:0031981 nuclear lumen
353 GO:0005654 nucleoplasm
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
413 GO:0005654 nucleoplasm
720 GO:0005829 cytosol
720 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006355 regulation of transcription, DNA-templated IEA
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
GO:0035196 production of miRNAs involved in gene silencing by miRNA IMP
GO:1903955 positive regulation of protein targeting to mitochondrion IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IBA
GO:0005654 nucleoplasm IDA
GO:0005829 cytosol IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10887155 A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.
11567019 SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators.
12097147 A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15378006 The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16371476 PDSM, a motif for phosphorylation-dependent SUMO modification.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18632581 The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.
18669648 A quantitative atlas of mitotic phosphorylation.
18794151 Regulation of cyclin D1 RNA stability by SNIP1.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22279524 Genetic mapping and exome sequencing identify variants associated with five novel diseases.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
25772364 SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
OMIM ID Disease Name
614501 Psychomotor retardation, epilepsy, and craniofacial dysmorphism
Domain Name Domain ID Source
FHA_dom IPR000253 InterPro
SMAD_FHA_dom_sf IPR008984 InterPro
FHA PF00498 Pfam
FHA_DOMAIN PS50006 PROSITE
FHA SM00240 SMART
SSF49879 SSF49879 SUPFAM
FHA cd00060 CDD