Protein: Q15750

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q15750 (Uniprot) TAB1_HUMAN TAB1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 human No
Uniprot: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 48 GO:0009059 macromolecule biosynthetic process 682 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
3 GO:0022607 cellular component assembly
3 GO:0060255 regulation of macromolecule metabolic process
48 GO:0044248 cellular catabolic process
48 GO:0070647 protein modification by small protein conjugation or removal
48 GO:0006508 proteolysis
48 GO:0060255 regulation of macromolecule metabolic process
48 GO:0007165 signal transduction
131 GO:0070647 protein modification by small protein conjugation or removal
131 GO:0006355 regulation of transcription, DNA-templated
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
516 GO:0019538 protein metabolic process
544 GO:0016070 RNA metabolic process
544 GO:0006464 cellular protein modification process
544 GO:0006796 phosphate-containing compound metabolic process
544 GO:0031325 positive regulation of cellular metabolic process
544 GO:0010604 positive regulation of macromolecule metabolic process
544 GO:0051173 positive regulation of nitrogen compound metabolic process
544 GO:0032268 regulation of cellular protein metabolic process
544 GO:0010468 regulation of gene expression
544 GO:0023051 regulation of signaling
544 GO:0007165 signal transduction
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
3 GO:0044430 cytoskeletal part
3 GO:0005829 cytosol
3 GO:0005634 nucleus
30 GO:0005829 cytosol
30 GO:0043232 intracellular non-membrane-bounded organelle
48 GO:0031410 cytoplasmic vesicle
48 GO:0012505 endomembrane system
48 GO:0005634 nucleus
48 GO:0005886 plasma membrane
131 GO:0005829 cytosol
131 GO:0043232 intracellular non-membrane-bounded organelle
131 GO:0005634 nucleus
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
447 GO:0005829 cytosol
447 GO:0043232 intracellular non-membrane-bounded organelle
447 GO:0005634 nucleus
516 GO:0005634 nucleus
522 GO:0005634 nucleus
544 GO:0005829 cytosol
544 GO:0005634 nucleus
682 GO:0005634 nucleus
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000185 activation of MAPKKK activity IEA
GO:0000187 activation of MAPK activity TAS
GO:0001701 in utero embryonic development IEA
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0003007 heart morphogenesis IEA
GO:0003279 cardiac septum development IEA
GO:0006470 protein dephosphorylation IEA
GO:0007179 transforming growth factor beta receptor signaling pathway IEA
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
GO:0007254 JNK cascade TAS
GO:0016579 protein deubiquitination TAS
GO:0030324 lung development IEA
GO:0035904 aorta development IEA
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
GO:0060976 coronary vasculature development IEA
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
GO:0010008 endosome membrane TAS
GO:0016607 nuclear speck IDA
GO:0043234 protein complex IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8638164 TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.
10094049 The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
10591208 The DNA sequence of human chromosome 22.
11323434 An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.
11460167 TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
11865055 IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.
12429732 TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16845370 The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
16879102 TAK1-binding protein 1 is a pseudophosphatase.
17560374 XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
18220336 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18669648 A quantitative atlas of mitotic phosphorylation.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
PPM-type_phosphatase_dom IPR001932 InterPro
PP2C IPR015655 InterPro
PPM-type_dom_sf IPR036457 InterPro
PP2C PF00481 Pfam
PPM_2 PS51746 PROSITE
PTHR13832 PTHR13832 PANTHER
PP2Cc SM00332 SMART
SSF81606 SSF81606 SUPFAM
PP2Cc cd00143 CDD