Protein: Q15750 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q15750 (Uniprot)	TAB1_HUMAN	TAB1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	human	No

Protein Function

Uniprot: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	48	GO:0009059	macromolecule biosynthetic process	682	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 44 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
3	GO:0022607	cellular component assembly
3	GO:0060255	regulation of macromolecule metabolic process
48	GO:0044248	cellular catabolic process
48	GO:0070647	protein modification by small protein conjugation or removal
48	GO:0006508	proteolysis
48	GO:0060255	regulation of macromolecule metabolic process
48	GO:0007165	signal transduction
131	GO:0070647	protein modification by small protein conjugation or removal
131	GO:0006355	regulation of transcription, DNA-templated
330	GO:0006464	cellular protein modification process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
3	GO:0044430	cytoskeletal part
3	GO:0005829	cytosol
3	GO:0005634	nucleus
30	GO:0005829	cytosol
30	GO:0043232	intracellular non-membrane-bounded organelle
48	GO:0031410	cytoplasmic vesicle
48	GO:0012505	endomembrane system
48	GO:0005634	nucleus
48	GO:0005886	plasma membrane
131	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000185	activation of MAPKKK activity	IEA
GO:0000187	activation of MAPK activity	TAS
GO:0001701	in utero embryonic development	IEA
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS
GO:0003007	heart morphogenesis	IEA
GO:0003279	cardiac septum development	IEA
GO:0006470	protein dephosphorylation	IEA
GO:0007179	transforming growth factor beta receptor signaling pathway	IEA

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0010008	endosome membrane	TAS
GO:0016607	nuclear speck	IDA
GO:0043234	protein complex	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 64 entries

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Interactor	Also a MoonDB EMF protein
2AAA_HUMAN	No
ACAP3_HUMAN	No
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
AMPL_HUMAN	No
ARAP1_HUMAN	No
ARRB2_HUMAN	Yes: P32121 (MoonDB)
ASGL1_HUMAN	No
CAR11_HUMAN	No
CASP6_HUMAN	No
CK5P3_HUMAN	No

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Publications Associated

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PMID	Article Title
8638164	TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.
10094049	The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
10591208	The DNA sequence of human chromosome 22.
11323434	An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.
11460167	TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
11865055	IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.
12429732	TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16845370	The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
16879102	TAK1-binding protein 1 is a pseudophosphatase.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
PP2C	IPR015655	InterPro
PP2C	PF00481	Pfam
PP2Cc	SM00332	SMART
PP2Cc	cd00143	CDD
PPM-type_dom_sf	IPR036457	InterPro
PPM-type_phosphatase_dom	IPR001932	InterPro
PPM_2	PS51746	PROSITE
PTHR13832	PTHR13832	PANTHER
SSF81606	SSF81606	SUPFAM

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