Protein: O60341 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O60341 (Uniprot)	KDM1A_HUMAN	KDM1A	Lysine-specific histone demethylase 1A	human	No

Protein Function

Uniprot: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating more..

MoonDB Dissimilar Functions

Showing 1 to 7 of 7 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	632	GO:0051641	cellular localization	872	4.17e-16	1.54e-157
GO:0006725	cellular aromatic compound metabolic process	103, 494	GO:0051641	cellular localization	872	2.74e-17	6.15e-158
GO:0009059	macromolecule biosynthetic process	662, 672	GO:0051641	cellular localization	872	1.95e-13	6.68e-127
GO:0016070	RNA metabolic process	644	GO:0051641	cellular localization	872	1.19e-11	3.64e-209
GO:0019219	regulation of nucleobase-containing compound metabolic process	834	GO:0051641	cellular localization	872	2.96e-08	1.52e-84
GO:0034641	cellular nitrogen compound metabolic process	595	GO:0051641	cellular localization	872	1.90e-19	2.28e-136
GO:0044260	cellular macromolecule metabolic process	591, 714, 787	GO:0051641	cellular localization	872	4.50e-03	3.02e-89

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
26	GO:0006464	cellular protein modification process
26	GO:0090304	nucleic acid metabolic process
26	GO:0010468	regulation of gene expression
37	GO:0007165	signal transduction
49	GO:0006464	cellular protein modification process
49	GO:0031324	negative regulation of cellular metabolic process
49	GO:0010629	negative regulation of gene expression
49	GO:0051172	negative regulation of nitrogen compound metabolic process
49	GO:0006357	regulation of transcription from RNA polymerase II promoter
49	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
26	GO:0005654	nucleoplasm
37	GO:0005829	cytosol
49	GO:0043232	intracellular non-membrane-bounded organelle
49	GO:0005654	nucleoplasm
92	GO:0005634	nucleus
103	GO:0070013	intracellular organelle lumen
103	GO:0005634	nucleus
140	GO:0043232	intracellular non-membrane-bounded organelle
145	GO:0070013	intracellular organelle lumen
145	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
GO:0000380	alternative mRNA splicing, via spliceosome	IEA
GO:0006351	transcription, DNA-templated	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	IMP
GO:0006482	protein demethylation	IMP
GO:0007596	blood coagulation	TAS
GO:0010569	regulation of double-strand break repair via homologous recombination	IMP
GO:0010976	positive regulation of neuron projection development	IEA
GO:0016575	histone deacetylation	IEA
GO:0021987	cerebral cortex development	IEA

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000784	nuclear chromosome, telomeric region	IDA
GO:0000790	nuclear chromatin	ISS
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005667	transcription factor complex	ISS
GO:0043234	protein complex	IDA
GO:1990391	DNA repair complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 237 entries

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Interactor	Also a MoonDB EMF protein
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
AKAP9_HUMAN	No
ANKE1_HUMAN	No
AP1G2_HUMAN	No
ASB10_HUMAN	No
ASB3_HUMAN	No
ASCC2_HUMAN	No
ASPP2_HUMAN	No
ATPK_HUMAN	No
B9D2_HUMAN	No

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Publications Associated

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PMID	Article Title
9628581	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
11102443	Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.
12032298	A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.
12493763	A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15620353	Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
15811342	Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process.
16079794	An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.
16079795	LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.
16140033	Regulation of LSD1 histone demethylase activity by its associated factors.

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OMIM Diseases Associated

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OMIM ID	Disease Name
616728	Cleft palate, psychomotor retardation, and distinctive facial features

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Protein Domains Associated

Showing 1 to 10 of 12 entries

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Domain Name	Domain ID	Source
Amino_oxidase	IPR002937	InterPro
Amino_oxidase	PF01593	Pfam
FAD/NAD-bd_sf	IPR036188	InterPro
Hist_Lys-spec_deMease	IPR017366	InterPro
Histone_Lys-demethylase	PIRSF038051	PIRSF
Homeobox-like_sf	IPR009057	InterPro
SSF46689	SSF46689	SUPFAM
SSF51905	SSF51905	SUPFAM
SWIRM	IPR007526	InterPro
SWIRM	PF04433	Pfam

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