Protein: Q8TBC4

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8TBC4 (Uniprot) UBA3_HUMAN UBA3 NEDD8-activating enzyme E1 catalytic subunit human No
Uniprot: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 376 GO:0016070 RNA metabolic process 719 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
644 GO:0032774 RNA biosynthetic process
644 GO:0034645 cellular macromolecule biosynthetic process
644 GO:0006464 cellular protein modification process
644 GO:0060255 regulation of macromolecule metabolic process
644 GO:0007165 signal transduction
719 GO:0006401 RNA catabolic process
719 GO:0016071 mRNA metabolic process
719 GO:0010629 negative regulation of gene expression
719 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
376 GO:0005829 cytosol
376 GO:0005634 nucleus
644 GO:0031981 nuclear lumen
719 GO:0005829 cytosol
719 GO:0043232 intracellular non-membrane-bounded organelle
719 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006464 cellular protein modification process TAS
GO:0006508 proteolysis TAS
GO:0007113 endomitotic cell cycle IEA
GO:0038061 NIK/NF-kappaB signaling TAS
GO:0043687 post-translational protein modification TAS
GO:0045116 protein neddylation IEA
GO:0045892 negative regulation of transcription, DNA-templated IEA
GO:0051726 regulation of cell cycle IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IBA
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9694792 A new NEDD8-ligating system for cullin-4A.
10207026 Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.
11230166 Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
12646924 Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.
12740388 Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.
14690597 The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15361859 A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15694336 Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
19250909 E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.
21269460 Initial characterization of the human central proteome.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
No results found.
Domain Name Domain ID Source
ThiF_NAD_FAD-bd IPR000594 InterPro
E2_binding IPR014929 InterPro
Uba3 IPR030468 InterPro
UBQ-activ_enz_E1_Cys_AS IPR033127 InterPro
Ubiquitin-activating_enz IPR035985 InterPro
NEDD8-ac_enz1_catalyticsu_C IPR037078 InterPro
ThiF PF00899 Pfam
E2_bind PF08825 Pfam
UBIQUITIN_ACTIVAT_2 PS00865 PROSITE
PTHR10953:SF6 PTHR10953:SF6 PANTHER
E2_bind SM01181 SMART
SSF69572 SSF69572 SUPFAM
T17306 T17306 PIR