Protein: Q9H0M0 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9H0M0 (Uniprot)	WWP1_HUMAN	WWP1	NEDD4-like E3 ubiquitin-protein ligase WWP1	human	No

Protein Function

Uniprot: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitin more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	373	GO:0009056	catabolic process	48	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
48	GO:0044248	cellular catabolic process
48	GO:0070647	protein modification by small protein conjugation or removal
48	GO:0006508	proteolysis
48	GO:0060255	regulation of macromolecule metabolic process
48	GO:0007165	signal transduction
373	GO:0034645	cellular macromolecule biosynthetic process
373	GO:0006139	nucleobase-containing compound metabolic process
373	GO:0060255	regulation of macromolecule metabolic process
664	GO:0044267	cellular protein metabolic process
664	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
48	GO:0031410	cytoplasmic vesicle
48	GO:0012505	endomembrane system
48	GO:0005634	nucleus
48	GO:0005886	plasma membrane
664	GO:0005829	cytosol
664	GO:0043232	intracellular non-membrane-bounded organelle
664	GO:0005634	nucleus
692	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007165	signal transduction	NAS
GO:0007417	central nervous system development	NAS
GO:0016567	protein ubiquitination	TAS
GO:0034220	ion transmembrane transport	TAS
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	IBA
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0045892	negative regulation of transcription, DNA-templated	ISS
GO:0046718	viral entry into host cell	TAS

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000151	ubiquitin ligase complex	NAS
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	IBA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000151	ubiquitin ligase complex	GO:0005886	plasma membrane	2.77e-20	3.36e-26
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A0A024R857_HUMAN	No
AAPK2_HUMAN	No
ARRD1_HUMAN	No
ARRD3_HUMAN	No
ASH2L_HUMAN	No
ATN1_HUMAN	No
CPSF6_HUMAN	No
DAZP2_HUMAN	Yes: Q15038 (MoonDB)
DIDO1_HUMAN	No
EWS_HUMAN	No

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Publications Associated

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PMID	Article Title
9169421	Identification of novel human WW domain-containing proteins by cloning of ligand targets.
9647693	Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
11230166	Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
11779188	Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.
12450395	Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.
12535537	Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.
15221015	Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).
15359284	The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16421571	DNA sequence and analysis of human chromosome 8.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
C2	PF00168	Pfam
C2	PS50004	PROSITE
C2	SM00239	SMART
C2_dom	IPR000008	InterPro
C2_domain_sf	IPR035892	InterPro
E3_ub_ligase_SMURF1	IPR024928	InterPro
E3_ub_ligase_SMURF1	PIRSF001569	PIRSF
HECT	PF00632	Pfam
HECT	PS50237	PROSITE
HECT_dom	IPR000569	InterPro

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