Protein: Q86VP1 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q86VP1 (Uniprot)	TAXB1_HUMAN	TAX1BP1	Tax1-binding protein 1	human	No

Protein Function

Uniprot: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	132, 444	GO:0033036	macromolecule localization	517	4.58e-19	9.70e-72

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 36 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
67	GO:0060255	regulation of macromolecule metabolic process
132	GO:0090304	nucleic acid metabolic process
132	GO:0060255	regulation of macromolecule metabolic process
134	GO:0044267	cellular protein metabolic process
134	GO:0060255	regulation of macromolecule metabolic process
134	GO:0007165	signal transduction
181	GO:0044267	cellular protein metabolic process
181	GO:0010467	gene expression
181	GO:0009059	macromolecule biosynthetic process
181	GO:0090304	nucleic acid metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
67	GO:0005634	nucleus
132	GO:0005634	nucleus
134	GO:0005829	cytosol
134	GO:0005634	nucleus
181	GO:0005829	cytosol
181	GO:0005654	nucleoplasm
264	GO:0012505	endomembrane system
444	GO:0005634	nucleus
517	GO:0005829	cytosol
517	GO:0012505	endomembrane system

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Protein GO Annotations

Biological Processes

Showing 1 to 5 of 5 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006915	apoptotic process	IEA
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	TAS
GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISS
GO:0032480	negative regulation of type I interferon production	TAS
GO:0043066	negative regulation of apoptotic process	IEA

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 71 entries

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Interactor	Also a MoonDB EMF protein
ARIP4_HUMAN	No
C19L2_HUMAN	No
CACO2_HUMAN	No
CBX8_HUMAN	No
COG7_HUMAN	No
CXXC1_HUMAN	No
DAXX_HUMAN	No
DAZP2_HUMAN	Yes: Q15038 (MoonDB)
DEST_HUMAN	No
EMIL1_HUMAN	No

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Publications Associated

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PMID	Article Title
10435631	The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
10920205	T6BP, a TRAF6-interacting protein involved in IL-1 signaling.
11230166	Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
12690205	Human chromosome 7: DNA sequence and biology.
12853948	The DNA sequence of human chromosome 7.
14530271	Protein profile of tax-associated complexes.
14697242	Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16959974	The consensus coding sequences of human breast and colorectal cancers.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 3 of 3 entries

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Domain Name	Domain ID	Source
CALCOCO1	PF07888	Pfam
CALCOCO1-like	IPR012852	InterPro
G02043	G02043	PIR

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