Protein: O15287

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O15287 (Uniprot) FANCG_HUMAN FANCG Fanconi anemia group G protein human No
Uniprot: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 462 6.88e-41 1.21e-84
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
462 GO:0090304 nucleic acid metabolic process
608 GO:0060255 regulation of macromolecule metabolic process
617 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
84 GO:0005634 nucleus
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
231 GO:0005634 nucleus
462 GO:0005634 nucleus
608 GO:0043232 intracellular non-membrane-bounded organelle
608 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000075 cell cycle checkpoint TAS
GO:0001541 ovarian follicle development IEA
GO:0006281 DNA repair TAS
GO:0007005 mitochondrion organization IMP
GO:0007286 spermatid development IEA
GO:0009314 response to radiation IEA
GO:0036297 interstrand cross-link repair TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm TAS
GO:0005730 nucleolus IDA
GO:0005739 mitochondrion IDA
GO:0005829 cytosol IDA
GO:0005886 plasma membrane IDA
GO:0043240 Fanconi anaemia nuclear complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005730 nucleolus GO:0005886 plasma membrane 7.70e-47 3.09e-07
PMID Article Title
9256465 The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.
9806548 The Fanconi anaemia group G gene FANCG is identical with XRCC9.
10373536 Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex.
11093276 Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.
12724401 A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
15164053 DNA sequence and analysis of human chromosome 9.
15299030 The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15502827 X-linked inheritance of Fanconi anemia complementation group B.
16116422 A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
16959974 The consensus coding sequences of human breast and colorectal cancers.
18212739 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.
18550849 HES1 is a novel interactor of the Fanconi anemia core complex.
22266823 Regulation of Rev1 by the Fanconi anemia core complex.
22343915 FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.
22705371 A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
OMIM ID Disease Name
614082 Fanconi anemia complementation group G
Domain Name Domain ID Source
TPR-like_helical_dom_sf IPR011990 InterPro
TPR_repeat IPR019734 InterPro
TPR SM00028 SMART
SSF48452 SSF48452 SUPFAM
T02244 T02244 PIR