Protein: O15287 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O15287 (Uniprot)	FANCG_HUMAN	FANCG	Fanconi anemia group G protein	human	No

Protein Function

Uniprot: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007166	cell surface receptor signaling pathway	108	GO:0006139	nucleobase-containing compound metabolic process	462	6.88e-41	1.21e-84

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction
108	GO:0010604	positive regulation of macromolecule metabolic process
108	GO:0006468	protein phosphorylation
462	GO:0090304	nucleic acid metabolic process
608	GO:0060255	regulation of macromolecule metabolic process
617	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
84	GO:0005634	nucleus
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
231	GO:0005634	nucleus
462	GO:0005634	nucleus
608	GO:0043232	intracellular non-membrane-bounded organelle
608	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000075	cell cycle checkpoint	TAS
GO:0001541	ovarian follicle development	IEA
GO:0006281	DNA repair	TAS
GO:0007005	mitochondrion organization	IMP
GO:0007286	spermatid development	IEA
GO:0009314	response to radiation	IEA
GO:0036297	interstrand cross-link repair	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005654	nucleoplasm	TAS
GO:0005730	nucleolus	IDA
GO:0005739	mitochondrion	IDA
GO:0005829	cytosol	IDA
GO:0005886	plasma membrane	IDA
GO:0043240	Fanconi anaemia nuclear complex	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005730	nucleolus	GO:0005886	plasma membrane	7.70e-47	3.09e-07

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AES_HUMAN	Yes: Q08117 (MoonDB)
BRCA2_HUMAN	No
CAN1_HUMAN	No
COG6_HUMAN	No
CP2E1_HUMAN	No
DOK5_HUMAN	No
ERCC1_HUMAN	No
FANCA_HUMAN	Yes: O15360 (MoonDB)
FANCC_HUMAN	No
FANCE_HUMAN	No

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Publications Associated

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PMID	Article Title
9256465	The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.
9806548	The Fanconi anaemia group G gene FANCG is identical with XRCC9.
10373536	Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex.
11093276	Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.
12724401	A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
15164053	DNA sequence and analysis of human chromosome 9.
15299030	The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15502827	X-linked inheritance of Fanconi anemia complementation group B.
16116422	A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614082	Fanconi anemia complementation group G

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Protein Domains Associated

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Domain Name	Domain ID	Source
SSF48452	SSF48452	SUPFAM
T02244	T02244	PIR
TPR	SM00028	SMART
TPR-like_helical_dom_sf	IPR011990	InterPro
TPR_repeat	IPR019734	InterPro

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