Protein: P05062

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P05062 (Uniprot) ALDOB_HUMAN ALDOB Fructose-bisphosphate aldolase B human Yes
No associated function.
Dissimilar Functions Manual Curation

Function 1: Glycolysis enzyme.

Function 2: "Modulates cell morphology and acidic vesicle distribution. The aldolase participates to the assembly and modulation of the vacuolar proton-translocating ATPases (V-ATPases) which belong to the proton pumps coupling the hydrolysis of cytosolic ATP to the proton transport out of the cytosol."

Publications (PMID): 21307348

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
29 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006000 fructose metabolic process IMP
GO:0006094 gluconeogenesis TAS
GO:0006096 glycolytic process IDA
GO:0006116 NADH oxidation IDA
GO:0030388 fructose 1,6-bisphosphate metabolic process IDA
GO:0032781 positive regulation of ATPase activity IGI
GO:0061621 canonical glycolysis TAS
GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate TAS
GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly IGI
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005815 microtubule organizing center IDA
GO:0005829 cytosol TAS
GO:0034451 centriolar satellite IDA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1967768 Molecular analysis of aldolase B genes in hereditary fructose intolerance.
2336380 A new aldolase B variant, N334K, is a common cause of hereditary fructose intolerance in Yugoslavia.
2410860 Human aldolase isozyme gene: the structure of multispecies aldolase B mRNAs.
2649152 Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host.
2830249 Human aldolase B gene: characterization of the genomic aldolase B gene and analysis of sequences required for multiple polyadenylations.
3016456 Characterization of the human aldolase B gene.
3383242 Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation.
6548561 Isolation and nucleotide sequence of a full-length cDNA coding for aldolase B from human liver.
6585824 Complete amino acid sequence for human aldolase B derived from cDNA and genomic clones.
6689266 Nucleotide sequence of a cDNA clone for human aldolase B.
7717389 Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance.
8162030 Identification of a novel mutation (Leu 256-->Pro) in the human aldolase B gene associated with hereditary fructose intolerance.
8299883 A partially active mutant aldolase B from a patient with hereditary fructose intolerance.
8535439 Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene.
10024431 Screening for hereditary fructose intolerance mutations by reverse dot-blot.
10970798 Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase.
11679716 The structure of human liver fructose-1,6-bisphosphate aldolase.
12205126 Molecular analysis of the aldolase B gene in patients with hereditary fructose intolerance from Spain.
15164053 DNA sequence and analysis of human chromosome 9.
15532022 Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene.
15880727 The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe.
18000879 Novel interaction partners of Bardet-Biedl syndrome proteins.
20848650 Hereditary fructose intolerance: functional study of two novel ALDOB natural variants and characterization of a partial gene deletion.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
OMIM ID Disease Name
229600 Hereditary fructose intolerance
Domain Name Domain ID Source
ADHUB A41505 PIR
FBA_I IPR000741 InterPro
Aldolase_TIM IPR013785 InterPro
Aldolase_I_AS IPR029768 InterPro
Glycolytic PF00274 Pfam
ALDOLASE_CLASS_I PS00158 PROSITE