Protein: P05062 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P05062 (Uniprot)	ALDOB_HUMAN	ALDOB	Fructose-bisphosphate aldolase B	human	Yes

Protein Function

No associated function.

Function 1: Glycolysis enzyme.

Function 2: "Modulates cell morphology and acidic vesicle distribution. The aldolase participates to the assembly and modulation of the vacuolar proton-translocating ATPases (V-ATPases) which belong to the proton pumps coupling the hydrolysis of cytosolic ATP to the proton transport out of the cytosol."

Publications (PMID): 21307348

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
29	GO:0060255	regulation of macromolecule metabolic process
29	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
29	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006000	fructose metabolic process	IMP
GO:0006094	gluconeogenesis	TAS
GO:0006096	glycolytic process	IDA
GO:0006116	NADH oxidation	IDA
GO:0030388	fructose 1,6-bisphosphate metabolic process	IDA
GO:0032781	positive regulation of ATPase activity	IGI
GO:0061621	canonical glycolysis	TAS
GO:0061624	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	TAS
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	IGI

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005815	microtubule organizing center	IDA
GO:0005829	cytosol	TAS
GO:0034451	centriolar satellite	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AGT2_HUMAN	No
ALDOA_HUMAN	No
ARF_HUMAN	No
BBS1_HUMAN	No
BBS2_HUMAN	No
BBS4_HUMAN	No
BBS7_HUMAN	No
BMR1A_HUMAN	No
BUB1_HUMAN	No
CRCM_HUMAN	No

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Publications Associated

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PMID	Article Title
1967768	Molecular analysis of aldolase B genes in hereditary fructose intolerance.
2336380	A new aldolase B variant, N334K, is a common cause of hereditary fructose intolerance in Yugoslavia.
2410860	Human aldolase isozyme gene: the structure of multispecies aldolase B mRNAs.
2649152	Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host.
2830249	Human aldolase B gene: characterization of the genomic aldolase B gene and analysis of sequences required for multiple polyadenylations.
3016456	Characterization of the human aldolase B gene.
3383242	Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation.
6548561	Isolation and nucleotide sequence of a full-length cDNA coding for aldolase B from human liver.
6585824	Complete amino acid sequence for human aldolase B derived from cDNA and genomic clones.
6689266	Nucleotide sequence of a cDNA clone for human aldolase B.

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OMIM Diseases Associated

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OMIM ID	Disease Name
229600	Hereditary fructose intolerance

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Protein Domains Associated

Showing 1 to 6 of 6 entries

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Domain Name	Domain ID	Source
ADHUB	A41505	PIR
ALDOLASE_CLASS_I	PS00158	PROSITE
Aldolase_I_AS	IPR029768	InterPro
Aldolase_TIM	IPR013785	InterPro
FBA_I	IPR000741	InterPro
Glycolytic	PF00274	Pfam

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