Protein: Q06124 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q06124 (Uniprot)	PTN11_HUMAN	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	human	No

Protein Function

Uniprot: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 a more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	187, 355	GO:0006139	nucleobase-containing compound metabolic process	572	1.10e-111	5.07e-25
GO:0034641	cellular nitrogen compound metabolic process	35, 180	GO:0007165	signal transduction	355, 187	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
111	GO:0006955	immune response
111	GO:0035556	intracellular signal transduction
111	GO:0009967	positive regulation of signal transduction
111	GO:0006468	protein phosphorylation
111	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
180	GO:0005829	cytosol
180	GO:0070013	intracellular organelle lumen
180	GO:0044428	nuclear part
187	GO:0005829	cytosol
187	GO:0005886	plasma membrane

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000077	DNA damage checkpoint	IEA
GO:0000187	activation of MAPK activity	IEA
GO:0006641	triglyceride metabolic process	IEA
GO:0007173	epidermal growth factor receptor signaling pathway	TAS
GO:0007229	integrin-mediated signaling pathway	IEA
GO:0007411	axon guidance	TAS
GO:0007420	brain development	IMP
GO:0007507	heart development	IMP
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS
GO:0009755	hormone-mediated signaling pathway	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IEA
GO:0005829	cytosol	TAS
GO:0043234	protein complex	IMP

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ANDR_HUMAN	Yes: P10275 (MoonDB)
CRKL_HUMAN	No
CSF3R_HUMAN	No
EGFR_HUMAN	Yes: P00533 (MoonDB)
ERBB2_HUMAN	Yes: P04626 (MoonDB)
FAK2_HUMAN	No
FLT3_HUMAN	No
FRS2_HUMAN	No
FRS3_HUMAN	No
GAB1_HUMAN	Yes: Q13480 (MoonDB)

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Publications Associated

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PMID	Article Title
1280823	Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.
1281790	Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.
7681217	Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.
7681589	A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.
7691811	Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
8041791	Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
8216283	Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase.
8810330	Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.
9062191	A family of proteins that inhibit signalling through tyrosine kinase receptors.
9491886	Crystal structure of the tyrosine phosphatase SHP-2.

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OMIM Diseases Associated

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OMIM ID	Disease Name
151100	LEOPARD syndrome 1
156250	Metachondromatosis
163950	Noonan syndrome 1
607785	Leukemia, juvenile myelomonocytic

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Protein Domains Associated

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Domain Name	Domain ID	Source
JN0805	JN0805	PIR
Prot-tyrosine_phosphatase-like	IPR029021	InterPro
PRTYPHPHTASE	PR00700	PRINTS
PTPase_domain	IPR000242	InterPro
PTPc	SM00194	SMART
PTPc_motif	SM00404	SMART
SH2	IPR000980	InterPro
SH2	PF00017	Pfam
SH2	PS50001	PROSITE
SH2	SM00252	SMART

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