Protein: P14921

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P14921 (Uniprot) ETS1_HUMAN ETS1 Protein C-ets-1 human No
Uniprot: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0006725 cellular aromatic compound metabolic process 736 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
172 GO:0060255 regulation of macromolecule metabolic process
341 GO:0070887 cellular response to chemical stimulus
341 GO:0045893 positive regulation of transcription, DNA-templated
341 GO:0006357 regulation of transcription from RNA polymerase II promoter
429 GO:0016070 RNA metabolic process
429 GO:0034645 cellular macromolecule biosynthetic process
429 GO:0044271 cellular nitrogen compound biosynthetic process
429 GO:0019538 protein metabolic process
429 GO:0010468 regulation of gene expression
429 GO:0010556 regulation of macromolecule biosynthetic process
429 GO:0019219 regulation of nucleobase-containing compound metabolic process
736 GO:0006139 nucleobase-containing compound metabolic process
736 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
169 GO:0005654 nucleoplasm
341 GO:0005654 nucleoplasm
429 GO:0070013 intracellular organelle lumen
429 GO:0005634 nucleus
736 GO:0005829 cytosol
736 GO:0070013 intracellular organelle lumen
736 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001666 response to hypoxia IEA
GO:0006955 immune response TAS
GO:0007565 female pregnancy IEA
GO:0008284 positive regulation of cell proliferation IEA
GO:0008285 negative regulation of cell proliferation TAS
GO:0009612 response to mechanical stimulus IEA
GO:0010595 positive regulation of endothelial cell migration IMP
GO:0010715 regulation of extracellular matrix disassembly IEA
GO:0021854 hypothalamus development IEA
GO:0021983 pituitary gland development IEA
GO:0030578 PML body organization IDA
GO:0032355 response to estradiol IEA
GO:0034616 response to laminar fluid shear stress IEA
GO:0044849 estrous cycle IEA
GO:0045648 positive regulation of erythrocyte differentiation IDA
GO:0045765 regulation of angiogenesis IMP
GO:0045766 positive regulation of angiogenesis IEA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0048870 cell motility IMP
GO:0050728 negative regulation of inflammatory response IEA
GO:0050729 positive regulation of inflammatory response IDA
GO:0051272 positive regulation of cellular component movement IMP
GO:0060055 angiogenesis involved in wound healing IEA
GO:0061614 pri-miRNA transcription from RNA polymerase II promoter IDA
GO:0070301 cellular response to hydrogen peroxide IEA
GO:0070555 response to interleukin-1 IEA
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005667 transcription factor complex IEA
GO:0005737 cytoplasm IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005667 transcription factor complex GO:0005737 cytoplasm 9.09e-11 9.47e-68
PMID Article Title
1614856 Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter.
2847145 Mammalian ets-1 and ets-2 genes encode highly conserved proteins.
2997781 The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.
3060801 Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene.
8231246 Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies.
8521493 The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation.
9333025 Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme.
10698492 EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.
11909962 Sp100 interacts with ETS-1 and stimulates its transcriptional activity.
15247905 SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15592518 SP100 inhibits ETS1 activity in primary endothelial cells.
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
17974005 The full-ORF clone resource of the German cDNA consortium.
18566588 Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization.
19377509 Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20378371 Transcription factor Ets-1 in cytokine and chemokine gene regulation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
TVHUET A32066 PIR
Ets_dom IPR000418 InterPro
Pointed_dom IPR003118 InterPro
SAM/pointed_sf IPR013761 InterPro
Transform_prot_C-ets IPR016311 InterPro
WH-like_DNA-bd_sf IPR036388 InterPro
WH_DNA-bd_sf IPR036390 InterPro
Ets PF00178 Pfam
SAM_PNT PF02198 Pfam
Transforming_factor_C-ets PIRSF001698 PIRSF
ETSDOMAIN PR00454 PRINTS
ETS_DOMAIN_1 PS00345 PROSITE
ETS_DOMAIN_2 PS00346 PROSITE
ETS_DOMAIN_3 PS50061 PROSITE
PNT PS51433 PROSITE
SAM_PNT SM00251 SMART
ETS SM00413 SMART
SSF46785 SSF46785 SUPFAM
SSF47769 SSF47769 SUPFAM