Protein: P32189

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P32189 (Uniprot) GLPK_HUMAN GK Glycerol kinase human Yes
Uniprot: Key enzyme in the regulation of glycerol uptake and metabolism.
Dissimilar Functions Manual Curation

Function 1: Glycerol kinase. Key enzyme in the regulation of glycerol uptake and metabolism.

Function 2: ATP-stimulated translocation protein. Binds to histones, interacts with porin or the voltage dependant anion channel. Lysosomal stabilization factor.

Publications (PMID): 15877277

Biological Processes
No results found.
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
411 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006071 glycerol metabolic process IMP
GO:0006641 triglyceride metabolic process IMP
GO:0016310 phosphorylation IEA
GO:0019432 triglyceride biosynthetic process TAS
GO:0019563 glycerol catabolic process IEA
GO:0046167 glycerol-3-phosphate biosynthetic process IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005739 mitochondrion IBA
GO:0005741 mitochondrial outer membrane IEA
GO:0005829 cytosol TAS
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7987308 The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.
8401584 Genomic scanning for expressed sequences in Xp21 identifies the glycerol kinase gene.
8499898 Isolation of the human Xp21 glycerol kinase gene by positional cloning.
8499912 Cloning of the X-linked glycerol kinase deficiency gene and its identification by sequence comparison to the Bacillus subtilis homologue.
8651297 Mutations and phenotype in isolated glycerol kinase deficiency.
9719371 Clinical heterogeneity and novel mutations in the glycerol kinase gene in three families with isolated glycerol kinase deficiency.
10736265 Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic trait.
10851254 Five cases of isolated glycerol kinase deficiency, including two families: failure to find genotype:phenotype correlation.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15772651 The DNA sequence of the human X chromosome.
OMIM ID Disease Name
307030 Glycerol kinase deficiency
Domain Name Domain ID Source
S36175 I37427 PIR
Carb_kinase_FGGY IPR000577 InterPro
Glycerol_kin IPR005999 InterPro
Carb_kinase_FGGY_CS IPR018483 InterPro
Carb_kinase_FGGY_N IPR018484 InterPro
Carb_kinase_FGGY_C IPR018485 InterPro
FGGY_N PF00370 Pfam
FGGY_C PF02782 Pfam
GlpK PIRSF000538 PIRSF
FGGY_KINASES_2 PS00445 PROSITE
FGGY_KINASES_1 PS00933 PROSITE
glycerol_kin TIGR01311 TIGRFAMs