Protein: P60411 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P60411 (Uniprot)	KR109_HUMAN	KRTAP10-9	Keratin-associated protein 10-9	human	No

Protein Function

Uniprot: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	461	GO:0033036	macromolecule localization	517	2.32e-08	6.09e-30
GO:0043170	macromolecule metabolic process	114	GO:0033036	macromolecule localization	517	2.48e-08	1.95e-27
GO:0044260	cellular macromolecule metabolic process	127, 340	GO:0033036	macromolecule localization	517	4.56e-06	3.25e-28

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
62	GO:0034645	cellular macromolecule biosynthetic process
62	GO:0090304	nucleic acid metabolic process
62	GO:1901362	organic cyclic compound biosynthetic process
62	GO:0060255	regulation of macromolecule metabolic process
80	GO:0051252	regulation of RNA metabolic process
80	GO:0010468	regulation of gene expression
114	GO:0019538	protein metabolic process
127	GO:0016070	RNA metabolic process
127	GO:0010467	gene expression
160	GO:0006355	regulation of transcription, DNA-templated

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
62	GO:0005829	cytosol
62	GO:0005634	nucleus
80	GO:0005634	nucleus
127	GO:0005634	nucleus
160	GO:0005634	nucleus
340	GO:0005634	nucleus
461	GO:0043232	intracellular non-membrane-bounded organelle
461	GO:0005634	nucleus
517	GO:0005829	cytosol
517	GO:0012505	endomembrane system

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0031424	keratinization	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0045095	keratin filament	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 222 entries

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Interactor	Also a MoonDB EMF protein
3BHS7_HUMAN	No
6PGL_HUMAN	No
A0A024R4S4_HUMAN	No
A8KA13_HUMAN	No
AAKB2_HUMAN	No
AAPK2_HUMAN	No
ACHG_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
AL3B1_HUMAN	No
ANFB_HUMAN	No

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Publications Associated

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PMID	Article Title
10830953	The DNA sequence of human chromosome 21.
14962103	Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.
15028290	A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
KAP	IPR002494	InterPro
Keratin_B2_2	PF13885	Pfam
PTHR23262	PTHR23262	PANTHER

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