Protein: Q9Y3E5 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9Y3E5 (Uniprot)	PTH2_HUMAN	PTRH2	Peptidyl-tRNA hydrolase 2, mitochondrial	human	Yes

Protein Function

Uniprot: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.

Dissimilar Functions Manual Curation

Function 1: Peptidyl-tRNA hydrolase. The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Condition: mitochondrion localisation.

Function 2: Apoptosis promoter, binds transcriptional co-repressors (AES and TLE1). Condition: cytoplasmic localisation (during apoptosis).

Publications (PMID): 15006356

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
238	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
238	GO:0005829	cytosol
238	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006915	apoptotic process	IEA
GO:0010629	negative regulation of gene expression	IMP
GO:2000210	positive regulation of anoikis	IMP
GO:2000811	negative regulation of anoikis	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005739	mitochondrion	IMP
GO:0005829	cytosol	IMP
GO:0016020	membrane	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AES_HUMAN	Yes: Q08117 (MoonDB)

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Publications Associated

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PMID	Article Title
10810093	Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
14660562	Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15006356	A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17974005	The full-ORF clone resource of the German cDNA consortium.
18669648	A quantitative atlas of mitotic phosphorylation.
21269460	Initial characterization of the human central proteome.
23186163	Toward a comprehensive characterization of a human cancer cell phosphoproteome.
25558065	Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.

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OMIM Diseases Associated

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OMIM ID	Disease Name
616263	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset

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Protein Domains Associated

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Domain Name	Domain ID	Source
arch_pth2	TIGR00283	TIGRFAMs
Pep_tRNA_hydro_II_dom_sf	IPR023476	InterPro
PTH2	IPR002833	InterPro
PTH2	PF01981	Pfam
PTH2	cd02430	CDD
SSF102462	SSF102462	SUPFAM
T46479	T46479	PIR

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