Protein: P02489 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P02489 (Uniprot)	CRYAA_HUMAN	CRYAA	Alpha-crystallin A chain	human	Yes

Protein Function

Uniprot: Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

Dissimilar Functions Manual Curation

Function 1: Molecular chaperone, protein folding.

Function 2: Structural protein of the lens, important for visual perception. Vertebrate crystallins resemble chaperones. Condition: eye lens localisation.

Publications (PMID): 1438232, 18587492, 14512969, 9467006, 6285380

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
88	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
88	GO:0012505	endomembrane system
88	GO:0031982	vesicle
289	GO:0005634	nucleus
525	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007601	visual perception	IMP
GO:0032387	negative regulation of intracellular transport	IDA
GO:0042026	protein refolding	ISS
GO:0043066	negative regulation of apoptotic process	IDA
GO:0050821	protein stabilization	IMP
GO:0050896	response to stimulus	IEA
GO:0051260	protein homooligomerization	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
CRBA1_HUMAN	No
CRBB2_HUMAN	No
CRGC_HUMAN	No
CRGD_HUMAN	No
CRYAB_HUMAN	Yes: P02511 (MoonDB)
GORS2_HUMAN	No
HSPB1_HUMAN	Yes: P04792 (MoonDB)
HSPB2_HUMAN	No
HSPB6_HUMAN	No
MIP_HUMAN	No

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Publications Associated

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PMID	Article Title
817940	The amino acid sequence of the A chain of human alpha-crystallin.
1730617	Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine.
2918909	A pseudo-exon in the functional human alpha A-crystallin gene.
3758227	Isolation and partial characterization of the human alpha A-crystallin gene.
8175657	Post-translational modifications of water-soluble human lens crystallins from young adults.
8587135	A reassessment of mammalian alpha A-crystallin sequences using DNA sequencing: implications for anthropoid affinities of tarsier.
8759518	Differential phosphorylation of alpha-A crystallin in human lens of different age.
8943244	Cloning, expression, and chaperone-like activity of human alphaA-crystallin.
8999933	Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.
9068373	Modifications of the water-insoluble human lens alpha-crystallins.

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OMIM Diseases Associated

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OMIM ID	Disease Name
604219	Cataract 9, multiple types

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Protein Domains Associated

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Domain Name	Domain ID	Source
A-crystallin/Hsp20_dom	IPR002068	InterPro
ACRYSTALLIN	PR00299	PRINTS
Alpha-crystallin/HSP	IPR001436	InterPro
Alpha-crystallin_A	IPR012274	InterPro
Alpha-crystallin_N	IPR003090	InterPro
Crystallin	PF00525	Pfam
CYHUAA	S03344	PIR
HSP20	IPR031107	InterPro
HSP20	PF00011	Pfam
HSP20-like_chaperone	IPR008978	InterPro

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