Protein: P02511 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P02511 (Uniprot)	CRYAB_HUMAN	CRYAB	Alpha-crystallin B chain	human	Yes

Protein Function

Uniprot: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

Dissimilar Functions Manual Curation

Function 1: Molecular chaperone, protein folding.

Function 2: Structural protein of the lens. Vertebrate crystallins resemble chaperones. Condition: eye lens localization.

Publications (PMID): 1438232, 6285380

MoonDB Network Modules

Biological Processes

Showing 1 to 7 of 7 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
88	GO:0007165	signal transduction
577	GO:0006464	cellular protein modification process
577	GO:0033554	cellular response to stress
577	GO:0006796	phosphate-containing compound metabolic process
577	GO:0031326	regulation of cellular biosynthetic process
577	GO:0010556	regulation of macromolecule biosynthetic process
577	GO:0009966	regulation of signal transduction

Previous1Next

Cellular Components

Showing 1 to 10 of 10 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
60	GO:0005634	nucleus
88	GO:0012505	endomembrane system
88	GO:0031982	vesicle
289	GO:0005634	nucleus
525	GO:0005829	cytosol
577	GO:0005829	cytosol
577	GO:0043232	intracellular non-membrane-bounded organelle
577	GO:0070013	intracellular organelle lumen
577	GO:0044428	nuclear part
577	GO:0031982	vesicle

Previous1Next

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 25 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001666	response to hypoxia	IEA
GO:0002088	lens development in camera-type eye	IEA
GO:0006457	protein folding	IEA
GO:0006936	muscle contraction	TAS
GO:0007021	tubulin complex assembly	IEA
GO:0007517	muscle organ development	IEA
GO:0007568	aging	IEA
GO:0010629	negative regulation of gene expression	IEA
GO:0010941	regulation of cell death	IMP
GO:0030308	negative regulation of cell growth	IEA

Previous1 2 3Next

Cellular Components

Showing 1 to 10 of 19 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IEA
GO:0005794	Golgi apparatus	IEA
GO:0005829	cytosol	IEA
GO:0009986	cell surface	IEA
GO:0014069	postsynaptic density	IEA
GO:0015630	microtubule cytoskeleton	IEA
GO:0030018	Z disc	IEA

Previous1 2Next

Dissimilar Cellular Components (PrOnto)

Showing 1 to 10 of 10 entries

Search:

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005794	Golgi apparatus	4.39e-25	2.14e-64
GO:0005634	nucleus	GO:0009986	cell surface	1.10e-44	1.49e-81
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005634	nucleus	GO:0097060	synaptic membrane	3.83e-05	1.48e-23
GO:0005654	nucleoplasm	GO:0005794	Golgi apparatus	1.14e-11	3.23e-62
GO:0005654	nucleoplasm	GO:0009986	cell surface	1.97e-37	5.46e-93
GO:0005654	nucleoplasm	GO:0030424	axon	9.82e-03	1.17e-43
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35
GO:0005654	nucleoplasm	GO:0097060	synaptic membrane	7.14e-05	4.72e-63
GO:0005829	cytosol	GO:0009986	cell surface	3.26e-22	6.81e-06

Previous1Next

All Protein Interactions

Showing 1 to 10 of 30 entries

Search:

Interactor	Also a MoonDB EMF protein
A4_HUMAN	No
AAKG3_HUMAN	No
BACH_HUMAN	No
CAN3_HUMAN	No
CCL22_HUMAN	No
CRBA1_HUMAN	No
CRBB2_HUMAN	No
CRGC_HUMAN	No
CRGD_HUMAN	No
CRYAA_HUMAN	Yes: P02489 (MoonDB)

Previous1 2 3Next

Publications Associated

Showing 1 to 10 of 34 entries

Search:

PMID	Article Title
838078	The primary structure of the B2 chain of human alpha-crystallin.
1407707	Accumulation of alpha B-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5'-flanking and coding sequence of the genomic DNA.
1560006	Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.
2387586	Human alpha B-crystallin gene and preferential promoter function in lens.
2539261	Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain.
7498159	The major protein expression profile and two-dimensional protein database of human heart.
8142454	Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens.
8175657	Post-translational modifications of water-soluble human lens crystallins from young adults.
8999933	Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.
9731540	A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy.

Previous1 2 3 4Next

OMIM Diseases Associated

Showing 1 to 4 of 4 entries

Search:

OMIM ID	Disease Name
608810	Myopathy, myofibrillar, 2
613763	Cataract 16, multiple types
613869	Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related
615184	Cardiomyopathy, dilated 1II

Previous1Next

Protein Domains Associated

Showing 1 to 10 of 15 entries

Search:

Domain Name	Domain ID	Source
A-crystallin/Hsp20_dom	IPR002068	InterPro
ACD_alphaB-crystallin	IPR037882	InterPro
ACD_alphaB-crystallin_HspB5	cd06498	CDD
ACRYSTALLIN	PR00299	PRINTS
Alpha-crystallin/HSP	IPR001436	InterPro
Alpha-crystallin_N	IPR003090	InterPro
Crystallin	PF00525	Pfam
CYHUAB	A35332	PIR
HSP20	IPR031107	InterPro
HSP20	PF00011	Pfam

Previous1 2Next