Protein: P62328 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P62328 (Uniprot)	TYB4_HUMAN	TMSB4X	Thymosin beta-4	human	Yes

Protein Function

Uniprot: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.

Dissimilar Functions Manual Curation

Function 1: Sequesters actin monomers.

Function 2: Secreted chemotaxis ligand. Extracellular modulator of biological processes, including cell migration, angiogenesis, wound healing, inflammation, and development. Condition: extracellular localisation.

Publications (PMID): 10581087, 21106936

MoonDB Network Modules

Biological Processes

Showing 1 to 2 of 2 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
51	GO:0060255	regulation of macromolecule metabolic process
67	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
51	GO:0005634	nucleus
67	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001649	osteoblast differentiation	IEA
GO:0002576	platelet degranulation	TAS
GO:0007015	actin filament organization	IEA
GO:0007253	cytoplasmic sequestering of NF-kappaB	IMP
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP
GO:0033209	tumor necrosis factor-mediated signaling pathway	IMP
GO:0042989	sequestering of actin monomers	IDA
GO:0043536	positive regulation of blood vessel endothelial cell migration	IGI
GO:0050727	regulation of inflammatory response	IMP
GO:1901222	regulation of NIK/NF-kappaB signaling	IGI

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005622	intracellular	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IDA
GO:0005856	cytoskeleton	IEA
GO:0031093	platelet alpha granule lumen	TAS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005622	intracellular	8.27e-38	5.46e-09
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ACTG_HUMAN	No
AKP8L_HUMAN	No
ANXA7_HUMAN	No
APLP1_HUMAN	No
CDN1A_HUMAN	Yes: P38936 (MoonDB)
COG6_HUMAN	No
EF1A1_HUMAN	No
F118B_HUMAN	No
FHL3_HUMAN	No
GG6L9_HUMAN	No

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Publications Associated

Showing 1 to 10 of 15 entries

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PMID	Article Title
1999398	Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable.
3500230	Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.
6548414	Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells.
10848969	Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity.
16010977	Molecular cloning and structural characterization of the functional human thymosin beta4 gene.
18669648	A quantitative atlas of mitotic phosphorylation.
19608861	Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460	Initial characterization of the human central proteome.
21406692	System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
A38682	I56000	PIR
Beta-thymosin	IPR001152	InterPro
Beta-thymosin_sf	IPR038386	InterPro
PTHR12021	PTHR12021	PANTHER
THY	SM00152	SMART
Thymosin	PF01290	Pfam
Thymosin_b4	PD005116	ProDom
THYMOSIN_B4	PS00500	PROSITE
Thymosin_beta	PIRSF001828	PIRSF

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