Protein: P78352 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P78352 (Uniprot)	DLG4_HUMAN	DLG4	Disks large homolog 4	human	No

Protein Function

Uniprot: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	345	GO:0007165	signal transduction	355	5.44e-126	5.27e-27
GO:0010646	regulation of cell communication	284	GO:0006725	cellular aromatic compound metabolic process	345	4.64e-30	1.07e-07

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
41	GO:0007165	signal transduction
186	GO:0048468	cell development
186	GO:0007166	cell surface receptor signaling pathway
186	GO:0044267	cellular protein metabolic process
186	GO:0035556	intracellular signal transduction
186	GO:0030182	neuron differentiation
186	GO:0006796	phosphate-containing compound metabolic process
186	GO:0120036	plasma membrane bounded cell projection organization
186	GO:0060255	regulation of macromolecule metabolic process
186	GO:0009966	regulation of signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
41	GO:0030054	cell junction
41	GO:0044459	plasma membrane part
186	GO:0005829	cytosol
186	GO:0005886	plasma membrane
186	GO:0031982	vesicle
284	GO:0005829	cytosol
284	GO:0005886	plasma membrane
313	GO:0005634	nucleus
333	GO:0016021	integral component of membrane
333	GO:0098590	plasma membrane region

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000165	MAPK cascade	TAS
GO:0002091	negative regulation of receptor internalization	ISS
GO:0006461	protein complex assembly	IDA
GO:0007165	signal transduction	TAS
GO:0007204	positive regulation of cytosolic calcium ion concentration	ISS
GO:0007268	chemical synaptic transmission	IBA
GO:0007399	nervous system development	TAS
GO:0007612	learning	TAS
GO:0016188	synaptic vesicle maturation	ISS
GO:0034220	ion transmembrane transport	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	ISS
GO:0005783	endoplasmic reticulum	ISS
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	ISS
GO:0008021	synaptic vesicle	ISS
GO:0008076	voltage-gated potassium channel complex	ISS
GO:0008328	ionotropic glutamate receptor complex	IBA
GO:0014069	postsynaptic density	IBA
GO:0016323	basolateral plasma membrane	IBA
GO:0030054	cell junction	ISS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ADRB1_HUMAN	No
CRIPT_HUMAN	No
CSKP_HUMAN	No
DLG3_HUMAN	No
DLGP1_HUMAN	No
DLGP2_HUMAN	No
DLGP3_HUMAN	No
DLGP4_HUMAN	No
ERBB2_HUMAN	Yes: P04626 (MoonDB)
ERBB4_HUMAN	No

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Publications Associated

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PMID	Article Title
7477295	Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.
9278515	Binding of neuroligins to PSD-95.
9286702	Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues.
10582582	Genomic organization of human DLG4, the gene encoding postsynaptic density 95.
10725395	The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.
10859302	GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.
11744724	The PDZ1 domain of SAP90. Characterization of structure and binding.
12151521	Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
16625196	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
DLG1-like	IPR016313	InterPro
DLG1_PEST_dom	IPR019590	InterPro
GK/Ca_channel_bsu	IPR008145	InterPro
Guanylate_kin	PF00625	Pfam
Guanylate_kin-like_dom	IPR008144	InterPro
GUANYLATE_KINASE_1	PS00856	PROSITE
GUANYLATE_KINASE_2	PS50052	PROSITE
Guanylate_kinase_CS	IPR020590	InterPro
GuKc	SM00072	SMART
MAGUK_DLGH	PIRSF001741	PIRSF

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