Protein: P78352

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P78352 (Uniprot) DLG4_HUMAN DLG4 Disks large homolog 4 human No
Uniprot: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006725 cellular aromatic compound metabolic process 345 4.64e-30 1.07e-07
GO:0006725 cellular aromatic compound metabolic process 345 GO:0007165 signal transduction 355 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
41 GO:0007165 signal transduction
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
284 GO:0009966 regulation of signal transduction
313 GO:0060255 regulation of macromolecule metabolic process
333 GO:0060255 regulation of macromolecule metabolic process
333 GO:0009966 regulation of signal transduction
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
412 GO:0019538 protein metabolic process
412 GO:0060255 regulation of macromolecule metabolic process
704 GO:0007165 signal transduction
772 GO:0006464 cellular protein modification process
772 GO:0006796 phosphate-containing compound metabolic process
772 GO:0032268 regulation of cellular protein metabolic process
772 GO:0009966 regulation of signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
41 GO:0030054 cell junction
41 GO:0044459 plasma membrane part
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
313 GO:0005634 nucleus
333 GO:0016021 integral component of membrane
333 GO:0098590 plasma membrane region
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
355 GO:0044459 plasma membrane part
396 GO:0012505 endomembrane system
412 GO:0005829 cytosol
412 GO:0005634 nucleus
772 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0002091 negative regulation of receptor internalization ISS
GO:0006461 protein complex assembly IDA
GO:0007165 signal transduction TAS
GO:0007204 positive regulation of cytosolic calcium ion concentration ISS
GO:0007268 chemical synaptic transmission IBA
GO:0007399 nervous system development TAS
GO:0007612 learning TAS
GO:0016188 synaptic vesicle maturation ISS
GO:0034220 ion transmembrane transport IEA
GO:0035176 social behavior IEA
GO:0035418 protein localization to synapse IDA
GO:0035641 locomotory exploration behavior IEA
GO:0045184 establishment of protein localization IDA
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IBA
GO:0046037 GMP metabolic process IEA
GO:0046710 GDP metabolic process IEA
GO:0048169 regulation of long-term neuronal synaptic plasticity ISS
GO:0050806 positive regulation of synaptic transmission ISS
GO:0050885 neuromuscular process controlling balance IEA
GO:0060997 dendritic spine morphogenesis ISS
GO:0071625 vocalization behavior IEA
GO:0097113 AMPA glutamate receptor clustering TAS
GO:0097120 receptor localization to synapse IBA
GO:2000310 regulation of NMDA receptor activity ISS
GO:2000463 positive regulation of excitatory postsynaptic potential ISS
GO:2000821 regulation of grooming behavior IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm ISS
GO:0005783 endoplasmic reticulum ISS
GO:0005829 cytosol TAS
GO:0005886 plasma membrane ISS
GO:0008021 synaptic vesicle ISS
GO:0008076 voltage-gated potassium channel complex ISS
GO:0008328 ionotropic glutamate receptor complex IBA
GO:0014069 postsynaptic density IBA
GO:0016323 basolateral plasma membrane IBA
GO:0030054 cell junction ISS
GO:0030666 endocytic vesicle membrane TAS
GO:0030863 cortical cytoskeleton IDA
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISS
GO:0032281 AMPA glutamate receptor complex ISS
GO:0032839 dendrite cytoplasm ISS
GO:0043197 dendritic spine ISS
GO:0044224 juxtaparanode region of axon ISS
GO:0044300 cerebellar mossy fiber IEA
GO:0044306 neuron projection terminus ISS
GO:0044309 neuron spine ISS
GO:0045202 synapse IDA
GO:0045211 postsynaptic membrane IDA
GO:0060076 excitatory synapse ISS
GO:0098839 postsynaptic density membrane IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7477295 Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.
9278515 Binding of neuroligins to PSD-95.
9286702 Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues.
10582582 Genomic organization of human DLG4, the gene encoding postsynaptic density 95.
10725395 The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.
10859302 GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.
11744724 The PDZ1 domain of SAP90. Characterization of structure and binding.
12151521 Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
16630835 SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.
19118189 Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.
23782696 Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.
25780553 The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis.
No results found.
Domain Name Domain ID Source
SH3_domain IPR001452 InterPro
PDZ IPR001478 InterPro
Guanylate_kin-like_dom IPR008144 InterPro
GK/Ca_channel_bsu IPR008145 InterPro
DLG1-like IPR016313 InterPro
PDZ_assoc IPR019583 InterPro
DLG1_PEST_dom IPR019590 InterPro
Guanylate_kinase_CS IPR020590 InterPro
P-loop_NTPase IPR027417 InterPro
SH3-like_dom_sf IPR036028 InterPro
PDZ_sf IPR036034 InterPro
SH3_1 PF00018 Pfam
PDZ PF00595 Pfam
Guanylate_kin PF00625 Pfam
PDZ_assoc PF10600 Pfam
MAGUK_N_PEST PF10608 Pfam
MAGUK_DLGH PIRSF001741 PIRSF
GUANYLATE_KINASE_1 PS00856 PROSITE
SH3 PS50002 PROSITE
GUANYLATE_KINASE_2 PS50052 PROSITE
PDZ PS50106 PROSITE
GuKc SM00072 SMART
PDZ SM00228 SMART
SH3 SM00326 SMART
MAGUK_N_PEST SM01277 SMART
SSF50044 SSF50044 SUPFAM
SSF50156 SSF50156 SUPFAM
SSF52540 SSF52540 SUPFAM
T09599 T09599 PIR