Protein: Q13387

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q13387 (Uniprot) JIP2_HUMAN MAPK8IP2 C-Jun-amino-terminal kinase-interacting protein 2 human No
Uniprot: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 595 GO:0007165 signal transduction 828 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
21 GO:0060255 regulation of macromolecule metabolic process
333 GO:0060255 regulation of macromolecule metabolic process
333 GO:0009966 regulation of signal transduction
410 GO:0010467 gene expression
410 GO:0007165 signal transduction
544 GO:0016070 RNA metabolic process
544 GO:0006464 cellular protein modification process
544 GO:0006796 phosphate-containing compound metabolic process
544 GO:0031325 positive regulation of cellular metabolic process
544 GO:0010604 positive regulation of macromolecule metabolic process
544 GO:0051173 positive regulation of nitrogen compound metabolic process
544 GO:0032268 regulation of cellular protein metabolic process
544 GO:0010468 regulation of gene expression
544 GO:0023051 regulation of signaling
544 GO:0007165 signal transduction
555 GO:0006464 cellular protein modification process
555 GO:0060255 regulation of macromolecule metabolic process
555 GO:0007165 signal transduction
560 GO:0006464 cellular protein modification process
560 GO:0060255 regulation of macromolecule metabolic process
560 GO:0007165 signal transduction
595 GO:0044271 cellular nitrogen compound biosynthetic process
595 GO:0006464 cellular protein modification process
595 GO:0035556 intracellular signal transduction
595 GO:0006139 nucleobase-containing compound metabolic process
595 GO:0031325 positive regulation of cellular metabolic process
595 GO:0010604 positive regulation of macromolecule metabolic process
595 GO:0051173 positive regulation of nitrogen compound metabolic process
595 GO:0031326 regulation of cellular biosynthetic process
595 GO:0010468 regulation of gene expression
828 GO:0007166 cell surface receptor signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
333 GO:0016021 integral component of membrane
333 GO:0098590 plasma membrane region
410 GO:0005634 nucleus
544 GO:0005829 cytosol
544 GO:0005634 nucleus
555 GO:0005634 nucleus
560 GO:0005829 cytosol
595 GO:0005654 nucleoplasm
828 GO:0016021 integral component of membrane
828 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001662 behavioral fear response ISS
GO:0007172 signal complex assembly TAS
GO:0007254 JNK cascade IEA
GO:0007617 mating behavior IEA
GO:0010469 regulation of receptor activity ISS
GO:0032874 positive regulation of stress-activated MAPK cascade IEA
GO:0035176 social behavior ISS
GO:0046328 regulation of JNK cascade IDA
GO:0046958 nonassociative learning ISS
GO:0048813 dendrite morphogenesis ISS
GO:0051966 regulation of synaptic transmission, glutamatergic ISS
GO:0060079 excitatory postsynaptic potential ISS
GO:2000310 regulation of NMDA receptor activity ISS
GO:2000311 regulation of AMPA receptor activity ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
GO:0014069 postsynaptic density ISS
GO:0043025 neuronal cell body IEA
GO:0043234 protein complex IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9110174 Large-scale concatenation cDNA sequencing.
10490659 The JIP group of mitogen-activated protein kinase scaffold proteins.
10591208 The DNA sequence of human chromosome 22.
10756100 cDNA cloning and mapping of a novel islet-brain/JNK interacting protein.
11378392 Fibroblast growth factor homologous factors are intracellular signaling proteins.
12529303 Reevaluating human gene annotation: a second-generation analysis of chromosome 22.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
No results found.
Domain Name Domain ID Source
SH3_domain IPR001452 InterPro
PTB/PI_dom IPR006020 InterPro
PH-like_dom_sf IPR011993 InterPro
JIP2_SH3 IPR035637 InterPro
PID PF00640 Pfam
SH3_9 PF14604 Pfam
PID PS01179 PROSITE
SH3 PS50002 PROSITE
SH3 SM00326 SMART
PTB SM00462 SMART
SSF50729 SSF50729 SUPFAM
SH3_JIP2 cd11942 CDD