Protein: Q15797

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q15797 (Uniprot) SMAD1_HUMAN SMAD1 Mothers against decapentaplegic homolog 1 human No
Uniprot: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 255 GO:0006725 cellular aromatic compound metabolic process 395 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
44 GO:0010467 gene expression
44 GO:0031324 negative regulation of cellular metabolic process
44 GO:0009889 regulation of biosynthetic process
44 GO:0060255 regulation of macromolecule metabolic process
51 GO:0060255 regulation of macromolecule metabolic process
54 GO:0010467 gene expression
54 GO:0006139 nucleobase-containing compound metabolic process
54 GO:0060255 regulation of macromolecule metabolic process
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
248 GO:0044267 cellular protein metabolic process
248 GO:0045893 positive regulation of transcription, DNA-templated
248 GO:0051246 regulation of protein metabolic process
248 GO:0007165 signal transduction
255 GO:0008283 cell proliferation
255 GO:0007166 cell surface receptor signaling pathway
255 GO:0006464 cellular protein modification process
255 GO:0060429 epithelium development
255 GO:0006139 nucleobase-containing compound metabolic process
255 GO:0006796 phosphate-containing compound metabolic process
255 GO:0006508 proteolysis
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
301 GO:0006464 cellular protein modification process
301 GO:0060255 regulation of macromolecule metabolic process
394 GO:0006464 cellular protein modification process
394 GO:0031325 positive regulation of cellular metabolic process
394 GO:0010604 positive regulation of macromolecule metabolic process
394 GO:0051173 positive regulation of nitrogen compound metabolic process
394 GO:0032268 regulation of cellular protein metabolic process
394 GO:0006355 regulation of transcription, DNA-templated
394 GO:0007165 signal transduction
395 GO:0006139 nucleobase-containing compound metabolic process
395 GO:0019538 protein metabolic process
412 GO:0019538 protein metabolic process
412 GO:0060255 regulation of macromolecule metabolic process
588 GO:0006355 regulation of transcription, DNA-templated
674 GO:0006464 cellular protein modification process
674 GO:0031324 negative regulation of cellular metabolic process
674 GO:0010605 negative regulation of macromolecule metabolic process
674 GO:0051172 negative regulation of nitrogen compound metabolic process
674 GO:0010604 positive regulation of macromolecule metabolic process
674 GO:2000112 regulation of cellular macromolecule biosynthetic process
674 GO:0010468 regulation of gene expression
674 GO:1903506 regulation of nucleic acid-templated transcription
674 GO:0007165 signal transduction
674 GO:0006351 transcription, DNA-templated
720 GO:0006464 cellular protein modification process
720 GO:0071310 cellular response to organic substance
720 GO:0006355 regulation of transcription, DNA-templated
720 GO:0006366 transcription from RNA polymerase II promoter
787 GO:0016070 RNA metabolic process
787 GO:0010467 gene expression
787 GO:0060255 regulation of macromolecule metabolic process
787 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
29 GO:0005634 nucleus
44 GO:0005829 cytosol
44 GO:0005634 nucleus
51 GO:0005634 nucleus
54 GO:0070013 intracellular organelle lumen
54 GO:0005634 nucleus
134 GO:0005829 cytosol
134 GO:0005634 nucleus
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
248 GO:0031981 nuclear lumen
255 GO:0012505 endomembrane system
255 GO:0016021 integral component of membrane
255 GO:0005886 plasma membrane
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
301 GO:0005829 cytosol
301 GO:0005634 nucleus
394 GO:0005654 nucleoplasm
395 GO:0005634 nucleus
412 GO:0005829 cytosol
412 GO:0005634 nucleus
588 GO:0031981 nuclear lumen
674 GO:0005829 cytosol
674 GO:0043232 intracellular non-membrane-bounded organelle
674 GO:0005654 nucleoplasm
720 GO:0005829 cytosol
720 GO:0005654 nucleoplasm
787 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade IEA
GO:0001657 ureteric bud development IEA
GO:0001710 mesodermal cell fate commitment IEA
GO:0002051 osteoblast fate commitment IEA
GO:0006366 transcription from RNA polymerase II promoter IEA
GO:0006954 inflammatory response IEA
GO:0007165 signal transduction NAS
GO:0007179 transforming growth factor beta receptor signaling pathway NAS
GO:0007183 SMAD protein complex assembly IDA
GO:0007276 gamete generation IEA
GO:0008285 negative regulation of cell proliferation IEA
GO:0009880 embryonic pattern specification ISS
GO:0010628 positive regulation of gene expression IDA
GO:0016579 protein deubiquitination TAS
GO:0030509 BMP signaling pathway TAS
GO:0030901 midbrain development IEA
GO:0030902 hindbrain development IEA
GO:0031053 primary miRNA processing TAS
GO:0042592 homeostatic process IEA
GO:0045669 positive regulation of osteoblast differentiation IEA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IC
GO:0051216 cartilage development IEA
GO:0060038 cardiac muscle cell proliferation IEA
GO:0060348 bone development IEA
GO:0060395 SMAD protein signal transduction NAS
GO:0061036 positive regulation of cartilage development IEA
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ISS
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005622 intracellular NAS
GO:0005634 nucleus NAS
GO:0005637 nuclear inner membrane IDA
GO:0005654 nucleoplasm TAS
GO:0005667 transcription factor complex IEA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0016021 integral component of membrane NAS
GO:0043234 protein complex IDA
GO:0071141 SMAD protein complex NAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005622 intracellular GO:0016021 integral component of membrane 0.00e+00 4.07e-291
GO:0005634 nucleus GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0005654 nucleoplasm GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0005667 transcription factor complex GO:0005737 cytoplasm 9.09e-11 9.47e-68
GO:0005667 transcription factor complex GO:0016021 integral component of membrane 2.72e-38 1.02e-158
GO:0005737 cytoplasm GO:0016021 integral component of membrane 2.01e-156 1.16e-04
GO:0005829 cytosol GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0016021 integral component of membrane GO:0043234 protein complex 6.03e-79 2.03e-37
PMID Article Title
8637600 A human Mad protein acting as a BMP-regulated transcriptional activator.
8653785 MADR1, a MAD-related protein that functions in BMP2 signaling pathways.
8663601 Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.
8673135 Mad-related genes in the human.
8774881 Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
9136927 The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
9759503 TGF-beta signal transduction.
10647776 Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.
10660046 OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
10708948 The Smad pathway.
10708949 TGF-beta signaling by Smad proteins.
11779505 Structural basis of Smad1 activation by receptor kinase phosphorylation.
12097147 A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
14630787 Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15647271 The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.
17292623 Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
17974005 The full-ORF clone resource of the German cDNA consortium.
21269460 Initial characterization of the human central proteome.
21690388 Smad inhibition by the Ste20 kinase Misshapen.
21898662 Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension.
21947082 USP15 is a deubiquitylating enzyme for receptor-activated SMADs.
22781750 Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
24554596 Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.
25755279 Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein signaling and mesenchymal stem cell differentiation.
No results found.
Domain Name Domain ID Source
SMAD_dom_Dwarfin-type IPR001132 InterPro
MAD_homology1_Dwarfin-type IPR003619 InterPro
SMAD_FHA_dom_sf IPR008984 InterPro
MAD_homology_MH1 IPR013019 InterPro
Dwarfin IPR013790 InterPro
SMAD-like_dom_sf IPR017855 InterPro
SMAD_MH1_sf IPR036578 InterPro
MH1 PF03165 Pfam
MH2 PF03166 Pfam
MH1 PS51075 PROSITE
MH2 PS51076 PROSITE
PTHR13703 PTHR13703 PANTHER
S68987 S68987 PIR
DWA SM00523 SMART
DWB SM00524 SMART
SSF49879 SSF49879 SUPFAM
SSF56366 SSF56366 SUPFAM