Protein: Q9UQE7

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9UQE7 (Uniprot) SMC3_HUMAN SMC3 Structural maintenance of chromosomes protein 3 human Yes
Uniprot: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. more..
Dissimilar Functions Manual Curation

Function 1: Central part of the cohesin complex, required for chromosome cohesion during the cell cycle.

Function 2: Basement membrane-associated chondroitin proteoglycan. Also, is a host cellular ligand of vaccinia virus neurovirulence factor N1L.

Publications (PMID): 9015313, 10375619, 19444697, 17927980

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
222 GO:0006139 nucleobase-containing compound metabolic process
222 GO:0060255 regulation of macromolecule metabolic process
222 GO:0007165 signal transduction
432 GO:0007165 signal transduction
776 GO:0006464 cellular protein modification process
776 GO:0035556 intracellular signal transduction
776 GO:0031325 positive regulation of cellular metabolic process
776 GO:0032268 regulation of cellular protein metabolic process
776 GO:0009966 regulation of signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
222 GO:0070013 intracellular organelle lumen
222 GO:0044428 nuclear part
432 GO:0005829 cytosol
432 GO:0005886 plasma membrane
776 GO:0005829 cytosol
776 GO:0043232 intracellular non-membrane-bounded organelle
776 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000278 mitotic cell cycle TAS
GO:0006275 regulation of DNA replication IMP
GO:0006281 DNA repair IEA
GO:0007062 sister chromatid cohesion TAS
GO:0019827 stem cell population maintenance IEA
GO:0032876 negative regulation of DNA endoreduplication IMP
GO:0044791 positive regulation by host of viral release from host cell IDA
GO:0051301 cell division IEA
GO:0051321 meiotic cell cycle IDA
GO:0051702 interaction with symbiont IDA
GO:1901673 regulation of mitotic spindle assembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000775 chromosome, centromeric region TAS
GO:0000785 chromatin IDA
GO:0000800 lateral element IEA
GO:0005604 basement membrane TAS
GO:0005622 intracellular IDA
GO:0005634 nucleus TAS
GO:0005654 nucleoplasm TAS
GO:0005694 chromosome TAS
GO:0005829 cytosol TAS
GO:0008278 cohesin complex NAS
GO:0016363 nuclear matrix IDA
GO:0030893 meiotic cohesin complex IDA
GO:0034991 nuclear meiotic cohesin complex IEA
GO:0097431 mitotic spindle pole IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005604 basement membrane GO:0005634 nucleus 3.73e-02 1.47e-24
PMID Article Title
9506951 Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.
11042152 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
11076961 Characterization of vertebrate cohesin complexes and their regulation in prophase.
11590136 A potential role for human cohesin in mitotic spindle aster assembly.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164054 The DNA sequence and comparative analysis of human chromosome 10.
15656913 Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3.
15837422 Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.
17105772 The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.
17273969 Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
18614053 Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18996922 Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA.
19367720 Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19907496 Cohesin acetylation speeds the replication fork.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22628566 In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex.
22885700 HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
OMIM ID Disease Name
610759 Cornelia de Lange syndrome 3
Domain Name Domain ID Source
RecF/RecN/SMC_N IPR003395 InterPro
SMC_hinge IPR010935 InterPro
SMC IPR024704 InterPro
P-loop_NTPase IPR027417 InterPro
SMC_hinge_sf IPR036277 InterPro
SMC_N PF02463 Pfam
SMC_hinge PF06470 Pfam
SMC PIRSF005719 PIRSF
SMC_hinge SM00968 SMART
SSF52540 SSF52540 SUPFAM
SSF75553 SSF75553 SUPFAM