Protein: P08183 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P08183 (Uniprot)	MDR1_HUMAN	ABCB1	Multidrug resistance protein 1	human	Yes

Protein Function

Uniprot: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Dissimilar Functions Manual Curation

Function 1: P-glycoprotein (transporter). Multi-pass membrane protein. Condition: membrane localisation.

Function 2: Regulation of volume-activated chloride channels.

Publications (PMID): 8887537, 10790147

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
511	GO:0010467	gene expression
511	GO:0051252	regulation of RNA metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
511	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000086	G2/M transition of mitotic cell cycle	IDA
GO:0006810	transport	TAS
GO:0006855	drug transmembrane transport	IEA
GO:0042493	response to drug	TAS
GO:0042908	xenobiotic transport	IEA
GO:0045332	phospholipid translocation	IDA
GO:0047484	regulation of response to osmotic stress	IMP
GO:0055085	transmembrane transport	TAS
GO:0072089	stem cell proliferation	IMP
GO:0099040	ceramide translocation	IDA

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005886	plasma membrane	TAS
GO:0009986	cell surface	IDA
GO:0016020	membrane	TAS
GO:0016021	integral component of membrane	IEA
GO:0016324	apical plasma membrane	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
BCCIP_HUMAN	No
CD4_HUMAN	No
LNX1_HUMAN	Yes: Q8TBB1 (MoonDB)
MARE1_HUMAN	No
PSB8_HUMAN	No
RING2_HUMAN	No
SIN1_HUMAN	No

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Publications Associated

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PMID	Article Title
1967175	Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
1972623	mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles.
2568832	P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.
2876781	Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
2897240	An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.
9038218	Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.
9473242	Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.
10716719	Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.
10790226	A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein.
11240981	Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

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OMIM Diseases Associated

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OMIM ID	Disease Name
612244	Inflammatory bowel disease 13

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Protein Domains Associated

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Domain Name	Domain ID	Source
AAA	SM00382	SMART
AAA+_ATPase	IPR003593	InterPro
ABC1_TM_dom	IPR011527	InterPro
ABC1_TM_sf	IPR036640	InterPro
ABC_membrane	PF00664	Pfam
ABC_TM1F	PS50929	PROSITE
ABC_tran	PF00005	Pfam
ABC_transporter-like	IPR003439	InterPro
ABC_TRANSPORTER_1	PS00211	PROSITE
ABC_TRANSPORTER_2	PS50893	PROSITE

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