Protein: Q9NPD3

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9NPD3 (Uniprot) EXOS4_HUMAN EXOSC4 Exosome complex component RRP41 human No
Uniprot: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006464 cellular protein modification process 375 GO:0016070 RNA metabolic process 719 5.81e-04 8.44e-05
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
719 GO:0006401 RNA catabolic process
719 GO:0016071 mRNA metabolic process
719 GO:0010629 negative regulation of gene expression
719 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
375 GO:0005829 cytosol
375 GO:0005634 nucleus
598 GO:0016021 integral component of membrane
719 GO:0005829 cytosol
719 GO:0043232 intracellular non-membrane-bounded organelle
719 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000460 maturation of 5.8S rRNA IMP
GO:0000956 nuclear-transcribed mRNA catabolic process IMP
GO:0006364 rRNA processing TAS
GO:0016075 rRNA catabolic process IBA
GO:0030307 positive regulation of cell growth IMP
GO:0031125 rRNA 3'-end processing IBA
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
GO:0034475 U4 snRNA 3'-end processing IBA
GO:0043488 regulation of mRNA stability TAS
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
GO:0045006 DNA deamination IDA
GO:0051607 defense response to virus IMP
GO:0071028 nuclear mRNA surveillance IMP
GO:0071044 histone mRNA catabolic process IMP
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing IBA
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000176 nuclear exosome (RNase complex) IBA
GO:0000177 cytoplasmic exosome (RNase complex) IBA
GO:0000178 exosome (RNase complex) IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005730 nucleolus NAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0035327 transcriptionally active chromatin IMP
GO:0045111 intermediate filament cytoskeleton IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10465791 The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases.
11110791 Three novel components of the human exosome.
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16421571 DNA sequence and analysis of human chromosome 8.
16912217 Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome.
17174896 Reconstitution, activities, and structure of the eukaryotic RNA exosome.
17545563 Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.
18172165 Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20368444 Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells.
20531389 Dis3-like 1: a novel exoribonuclease associated with the human exosome.
21255825 The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
21269460 Initial characterization of the human central proteome.
21791617 DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
No results found.
Domain Name Domain ID Source
ExoRNase_PH_dom1 IPR001247 InterPro
ExoRNase_PH_dom2 IPR015847 InterPro
Ribosomal_S5_D2-typ_fold IPR020568 InterPro
PNPase/RNase_PH_dom_sf IPR027408 InterPro
ExoRNase_PH_dom2_sf IPR036345 InterPro
RNase_PH PF01138 Pfam
RNase_PH_C PF03725 Pfam
SSF54211 SSF54211 SUPFAM
SSF55666 SSF55666 SUPFAM