Protein: P62993

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P62993 (Uniprot) GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 human No
Uniprot: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 15, 166, 177, 202, 215, 254, 306 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 1.88e-02 4.66e-37
GO:0043170 macromolecule metabolic process 20, 387 GO:0022610 biological adhesion 869 2.68e-16 4.92e-03
GO:0034641 cellular nitrogen compound metabolic process 35, 180, 327, 492 GO:0007165 signal transduction 355, 486, 803, 187 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 35, 180, 327, 492 GO:0022610 biological adhesion 869 6.87e-63 4.34e-65
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 180, 327, 492 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0009059 macromolecule biosynthetic process 682 2.49e-18 9.18e-29
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 698 6.88e-41 1.21e-84
GO:0034641 cellular nitrogen compound metabolic process 35, 180, 327, 492 GO:0010646 regulation of cell communication 284 1.59e-39 2.52e-03
GO:0007165 signal transduction 187, 355, 486 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 4.83e-02 1.79e-71
GO:0007165 signal transduction 187, 355, 486 GO:0006139 nucleobase-containing compound metabolic process 698 1.10e-111 5.07e-25
GO:0010646 regulation of cell communication 284 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 2.08e-06 5.20e-107
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 698 6.71e-28 7.52e-07
GO:0044260 cellular macromolecule metabolic process 589 GO:0022610 biological adhesion 869 6.74e-23 3.02e-10
GO:0009059 macromolecule biosynthetic process 682 GO:0022610 biological adhesion 869 2.22e-23 6.08e-57
GO:0006139 nucleobase-containing compound metabolic process 698 GO:0022610 biological adhesion 869 2.30e-55 4.36e-110
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
15 GO:0044267 cellular protein metabolic process
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
21 GO:0060255 regulation of macromolecule metabolic process
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
38 GO:0007165 signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
115 GO:0006464 cellular protein modification process
115 GO:0060255 regulation of macromolecule metabolic process
166 GO:0044267 cellular protein metabolic process
166 GO:0006139 nucleobase-containing compound metabolic process
166 GO:0060255 regulation of macromolecule metabolic process
166 GO:0007165 signal transduction
177 GO:0044267 cellular protein metabolic process
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
220 GO:0060255 regulation of macromolecule metabolic process
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
259 GO:0007165 signal transduction
274 GO:0007165 signal transduction
279 GO:0060255 regulation of macromolecule metabolic process
284 GO:0009966 regulation of signal transduction
306 GO:0044267 cellular protein metabolic process
306 GO:0060255 regulation of macromolecule metabolic process
306 GO:0007165 signal transduction
313 GO:0060255 regulation of macromolecule metabolic process
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
358 GO:0006464 cellular protein modification process
358 GO:0060255 regulation of macromolecule metabolic process
358 GO:0007165 signal transduction
387 GO:0019538 protein metabolic process
387 GO:0060255 regulation of macromolecule metabolic process
387 GO:0007165 signal transduction
432 GO:0007165 signal transduction
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
486 GO:0007166 cell surface receptor signaling pathway
486 GO:0006464 cellular protein modification process
486 GO:0060255 regulation of macromolecule metabolic process
492 GO:0044271 cellular nitrogen compound biosynthetic process
492 GO:0051252 regulation of RNA metabolic process
492 GO:2000112 regulation of cellular macromolecule biosynthetic process
492 GO:0010468 regulation of gene expression
499 GO:0006464 cellular protein modification process
499 GO:0060255 regulation of macromolecule metabolic process
563 GO:0044267 cellular protein metabolic process
563 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0010646 regulation of cell communication
563 GO:0060255 regulation of macromolecule metabolic process
563 GO:0023051 regulation of signaling
563 GO:0007165 signal transduction
589 GO:0016070 RNA metabolic process
589 GO:0010467 gene expression
589 GO:0031325 positive regulation of cellular metabolic process
589 GO:2000112 regulation of cellular macromolecule biosynthetic process
589 GO:0019219 regulation of nucleobase-containing compound metabolic process
590 GO:0048468 cell development
590 GO:0007166 cell surface receptor signaling pathway
590 GO:0022607 cellular component assembly
590 GO:0032989 cellular component morphogenesis
590 GO:0006464 cellular protein modification process
590 GO:0006928 movement of cell or subcellular component
590 GO:0030182 neuron differentiation
590 GO:0120036 plasma membrane bounded cell projection organization
590 GO:0010628 positive regulation of gene expression
590 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
590 GO:0051128 regulation of cellular component organization
590 GO:0042325 regulation of phosphorylation
590 GO:0051246 regulation of protein metabolic process
590 GO:0006357 regulation of transcription from RNA polymerase II promoter
599 GO:0006464 cellular protein modification process
599 GO:0016310 phosphorylation
617 GO:0007165 signal transduction
664 GO:0044267 cellular protein metabolic process
664 GO:0010467 gene expression
664 GO:0090304 nucleic acid metabolic process
664 GO:0060255 regulation of macromolecule metabolic process
664 GO:0007165 signal transduction
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
696 GO:0022607 cellular component assembly
696 GO:0006464 cellular protein modification process
696 GO:0060255 regulation of macromolecule metabolic process
696 GO:0007165 signal transduction
698 GO:0090304 nucleic acid metabolic process
698 GO:0010646 regulation of cell communication
698 GO:0060255 regulation of macromolecule metabolic process
698 GO:0023051 regulation of signaling
698 GO:0007165 signal transduction
743 GO:0007165 signal transduction
745 GO:0048468 cell development
745 GO:0007166 cell surface receptor signaling pathway
745 GO:0010467 gene expression
745 GO:0048699 generation of neurons
745 GO:0006139 nucleobase-containing compound metabolic process
745 GO:0060255 regulation of macromolecule metabolic process
803 GO:0007166 cell surface receptor signaling pathway
803 GO:0044267 cellular protein metabolic process
803 GO:0071310 cellular response to organic substance
803 GO:0035556 intracellular signal transduction
803 GO:0009966 regulation of signal transduction
869 GO:0007155 cell adhesion
869 GO:0048468 cell development
869 GO:0016477 cell migration
869 GO:0000902 cell morphogenesis
869 GO:0044255 cellular lipid metabolic process
869 GO:0071363 cellular response to growth factor stimulus
869 GO:0072359 circulatory system development
869 GO:0009059 macromolecule biosynthetic process
869 GO:0022008 neurogenesis
869 GO:0019637 organophosphate metabolic process
869 GO:0018108 peptidyl-tyrosine phosphorylation
869 GO:0120036 plasma membrane bounded cell projection organization
869 GO:1902533 positive regulation of intracellular signal transduction
869 GO:0045860 positive regulation of protein kinase activity
869 GO:0043408 regulation of MAPK cascade
869 GO:2000145 regulation of cell motility
869 GO:0042127 regulation of cell proliferation
869 GO:0010468 regulation of gene expression
869 GO:2000026 regulation of multicellular organismal development
869 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
18 GO:0005829 cytosol
18 GO:0070062 extracellular exosome
20 GO:0005886 plasma membrane
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
115 GO:0005829 cytosol
115 GO:0005634 nucleus
166 GO:0005829 cytosol
166 GO:0070013 intracellular organelle lumen
166 GO:0044428 nuclear part
166 GO:0005886 plasma membrane
177 GO:0005634 nucleus
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
220 GO:0005634 nucleus
254 GO:0005829 cytosol
254 GO:0005634 nucleus
259 GO:0005886 plasma membrane
274 GO:0005829 cytosol
274 GO:0012505 endomembrane system
274 GO:0031982 vesicle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
306 GO:0070062 extracellular exosome
313 GO:0005634 nucleus
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
355 GO:0044459 plasma membrane part
358 GO:0012505 endomembrane system
358 GO:0005615 extracellular space
358 GO:0005886 plasma membrane
358 GO:0031982 vesicle
387 GO:0005829 cytosol
387 GO:0005654 nucleoplasm
432 GO:0005829 cytosol
432 GO:0005886 plasma membrane
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
467 GO:0005654 nucleoplasm
486 GO:0005829 cytosol
486 GO:0005634 nucleus
486 GO:0031982 vesicle
492 GO:0044428 nuclear part
499 GO:0005829 cytosol
499 GO:0031981 nuclear lumen
563 GO:0005634 nucleus
589 GO:0005829 cytosol
589 GO:0005634 nucleus
590 GO:0005829 cytosol
590 GO:0005634 nucleus
590 GO:0005886 plasma membrane
664 GO:0005829 cytosol
664 GO:0043232 intracellular non-membrane-bounded organelle
664 GO:0005634 nucleus
682 GO:0005634 nucleus
696 GO:0005829 cytosol
696 GO:0043232 intracellular non-membrane-bounded organelle
696 GO:0005634 nucleus
698 GO:0043232 intracellular non-membrane-bounded organelle
698 GO:0031981 nuclear lumen
698 GO:0005886 plasma membrane
743 GO:0012505 endomembrane system
745 GO:0005634 nucleus
803 GO:0016021 integral component of membrane
803 GO:0005886 plasma membrane
817 GO:0070013 intracellular organelle lumen
817 GO:0005634 nucleus
869 GO:0012505 endomembrane system
869 GO:0005615 extracellular space
869 GO:0044459 plasma membrane part
869 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0007173 epidermal growth factor receptor signaling pathway TAS
GO:0007265 Ras protein signal transduction TAS
GO:0007267 cell-cell signaling TAS
GO:0007411 axon guidance TAS
GO:0007568 aging IEA
GO:0008286 insulin receptor signaling pathway TAS
GO:0008543 fibroblast growth factor receptor signaling pathway TAS
GO:0016032 viral process IEA
GO:0016477 cell migration IBA
GO:0030154 cell differentiation IBA
GO:0030838 positive regulation of actin filament polymerization IEA
GO:0031295 T cell costimulation TAS
GO:0031623 receptor internalization IMP
GO:0035635 entry of bacterium into host cell TAS
GO:0035723 interleukin-15-mediated signaling pathway TAS
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
GO:0038083 peptidyl-tyrosine autophosphorylation IBA
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0038128 ERBB2 signaling pathway TAS
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
GO:0042127 regulation of cell proliferation IBA
GO:0042770 signal transduction in response to DNA damage IMP
GO:0043408 regulation of MAPK cascade IEA
GO:0045087 innate immune response IBA
GO:0046854 phosphatidylinositol phosphorylation IEA
GO:0048646 anatomical structure formation involved in morphogenesis IEA
GO:0050900 leukocyte migration TAS
GO:0051291 protein heterooligomerization IEA
GO:0051897 positive regulation of protein kinase B signaling TAS
GO:0060670 branching involved in labyrinthine layer morphogenesis IEA
GO:0061024 membrane organization TAS
GO:0065009 regulation of molecular function IEA
GO:0071479 cellular response to ionizing radiation IMP
GO:2000379 positive regulation of reactive oxygen species metabolic process IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm IDA
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005768 endosome IDA
GO:0005794 Golgi apparatus IEA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0005911 cell-cell junction IEA
GO:0008180 COP9 signalosome IDA
GO:0012506 vesicle membrane IEA
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
GO:0070062 extracellular exosome IDA
GO:0070436 Grb2-EGFR complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005768 endosome 4.09e-12 7.34e-15
GO:0005634 nucleus GO:0005794 Golgi apparatus 4.39e-25 2.14e-64
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0012506 vesicle membrane 9.35e-29 3.51e-48
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0005768 endosome 1.29e-11 1.85e-14
GO:0005654 nucleoplasm GO:0005794 Golgi apparatus 1.14e-11 3.23e-62
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0005911 cell-cell junction 3.44e-02 2.10e-14
GO:0005654 nucleoplasm GO:0012506 vesicle membrane 4.66e-23 1.85e-52
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
GO:0005730 nucleolus GO:0005794 Golgi apparatus 1.35e-04 9.69e-28
GO:0005730 nucleolus GO:0005886 plasma membrane 7.70e-47 3.09e-07
Interactor Also a MoonDB EMF protein
DDT4L_HUMAN Yes: Q96D03 (MoonDB)
ASPP2_HUMAN No
ARI5A_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
REL_HUMAN No
GLYR1_HUMAN No
IKZF3_HUMAN No
VP37C_HUMAN Yes: A5D8V6 (MoonDB)
AES_HUMAN Yes: Q08117 (MoonDB)
RBTN2_HUMAN No
CA094_HUMAN No
KPRP_HUMAN No
SESQ1_HUMAN No
SH24A_HUMAN No
NIF3L_HUMAN No
AGR2_HUMAN No
NTM2F_HUMAN No
CDC42_HUMAN Yes: P60953 (MoonDB)
NU4M_HUMAN No
K2C8_HUMAN No
FBF1_HUMAN No
ABI3_HUMAN No
ADA15_HUMAN No
FOXH1_HUMAN No
HOMEZ_HUMAN No
ESTD_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
PNMA5_HUMAN No
F110A_HUMAN No
GPAN1_HUMAN No
HXC8_HUMAN No
TRI39_HUMAN No
A2RU56_HUMAN No
A2MG_HUMAN Yes: P01023 (MoonDB)
AAKB1_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
ABL2_HUMAN Yes: P42684 (MoonDB)
ACAP1_HUMAN No
ACK1_HUMAN No
ACKR3_HUMAN No
AEBP1_HUMAN No
AFF2_HUMAN No
AIRE_HUMAN No
AKAP2_HUMAN No
AKAP6_HUMAN No
AMBP_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
ANGT_HUMAN No
ANK2_HUMAN No
AP4S1_HUMAN No
APOH_HUMAN No
APOL5_HUMAN No
AR6P4_HUMAN No
ARHG5_HUMAN No
ARHGB_HUMAN No
ASAP1_HUMAN No
ASAP2_HUMAN No
ASB16_HUMAN No
ASXL1_HUMAN No
ATP8_HUMAN No
AUNIP_HUMAN No
B2MG_HUMAN No
BAD_HUMAN No
BAZ2A_HUMAN No
BCAP_HUMAN No
BCR_HUMAN No
BICRA_HUMAN No
BIN1_HUMAN Yes: O00499 (MoonDB)
BLNK_HUMAN No
BRCA2_HUMAN No
BRD4_HUMAN No
BRPF3_HUMAN No
BTK_HUMAN No
CASB_HUMAN No
CASC3_HUMAN No
CASP2_HUMAN No
CBLB_HUMAN No
CBL_HUMAN No
CCR10_HUMAN No
CD2AP_HUMAN No
CDC27_HUMAN No
CDKL5_HUMAN No
CDN1B_HUMAN Yes: P46527 (MoonDB)
CE170_HUMAN No
CELF2_HUMAN No
CELR3_HUMAN No
CFAH_HUMAN No
CHRD_HUMAN No
CKAP5_HUMAN No
CKS2_HUMAN No
CLNK_HUMAN No
CLUS_HUMAN No
CNTFR_HUMAN No
CNTP1_HUMAN No
CO6_HUMAN No
COPB_HUMAN No
CP4F2_HUMAN No
CPSF7_HUMAN No
CRBB3_HUMAN No
CRBN_HUMAN No
CRK_HUMAN Yes: P46108 (MoonDB)
CSF1R_HUMAN No
CSF3R_HUMAN No
CTGE5_HUMAN No
CU058_HUMAN No
CUTA_HUMAN No
CX6A1_HUMAN No
CYH2_HUMAN No
DAB2_HUMAN No
DAG1_HUMAN No
DCE1_HUMAN No
DCTN2_HUMAN No
DDX17_HUMAN No
DJB11_HUMAN No
DLG4_HUMAN Yes: P78352 (MoonDB)
DLGP1_HUMAN No
DLGP2_HUMAN No
DLGP3_HUMAN No
DLGP4_HUMAN No
DLX4_HUMAN No
DNJA3_HUMAN No
DOCK1_HUMAN No
DOCK3_HUMAN No
DOCK4_HUMAN No
DPOD1_HUMAN No
DPPA4_HUMAN No
DREB_HUMAN No
DTX1_HUMAN No
DTX3_HUMAN No
DUS15_HUMAN No
DVL2_HUMAN No
DYN1_HUMAN No
DYN2_HUMAN Yes: P50570 (MoonDB)
E2F2_HUMAN No
EAA2_HUMAN No
ECHM_HUMAN No
ECT2_HUMAN No
EFHC2_HUMAN No
EFS_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
EHMT2_HUMAN No
EIF3D_HUMAN No
ELK3_HUMAN No
ENOA_HUMAN Yes: P06733 (MoonDB)
EP300_HUMAN Yes: Q09472 (MoonDB)
EPHB1_HUMAN No
EPS15_HUMAN Yes: P42566 (MoonDB)
EPS8_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERBB3_HUMAN Yes: P21860 (MoonDB)
ERBB4_HUMAN No
ERRFI_HUMAN No
ETV6_HUMAN No
EURL_HUMAN No
EXTL1_HUMAN No
EXTL3_HUMAN No
FABPL_HUMAN No
FAK1_HUMAN No
FANCA_HUMAN Yes: O15360 (MoonDB)
FCG2B_HUMAN No
FCG2C_HUMAN No
FETUA_HUMAN No
FGFR2_HUMAN No
FHOD1_HUMAN No
FINC_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
FLNB_HUMAN No
FLNC_HUMAN No
FOXJ1_HUMAN No
FRIH_HUMAN No
FRIL_HUMAN No
FUBP2_HUMAN No
FUBP3_HUMAN No
FUMH_HUMAN No
GAB1_HUMAN Yes: Q13480 (MoonDB)
GAB2_HUMAN No
GABR1_HUMAN No
GARE1_HUMAN No
GASR_HUMAN No
GCDH_HUMAN No
GGN_HUMAN No
GHR_HUMAN No
GIT1_HUMAN No
GNS_HUMAN No
GPR45_HUMAN No
GRB10_HUMAN No
GRIP2_HUMAN No
GRP78_HUMAN No
GSTK1_HUMAN No
H10_HUMAN No
HCN2_HUMAN No
HELZ_HUMAN No
HEM0_HUMAN No
HIBCH_HUMAN No
HIPK3_HUMAN No
HMGN2_HUMAN No
HMGN3_HUMAN No
HNRPC_HUMAN No
HNRPK_HUMAN Yes: P61978 (MoonDB)
HNRPR_HUMAN No
HPT_HUMAN No
I20L2_HUMAN No
ICAL_HUMAN No
ID4_HUMAN No
IL2RG_HUMAN No
IL3RA_HUMAN No
IL5RA_HUMAN No
IMA1_HUMAN No
INCA1_HUMAN No
ITIH4_HUMAN No
JAK2_HUMAN No
K154L_HUMAN No
KCNB2_HUMAN No
KCNH7_HUMAN No
KCNN1_HUMAN No
KCNQ1_HUMAN No
KHDR1_HUMAN No
KI13A_HUMAN No
KIF3A_HUMAN No
KIT_HUMAN No
KMT2B_HUMAN No
LAP2B_HUMAN No
LAT_HUMAN No
LCK_HUMAN No
LCP2_HUMAN No
LEPR_HUMAN No
LMX1A_HUMAN No
LNX2_HUMAN Yes: Q8N448 (MoonDB)
LY6D_HUMAN No
LZTS2_HUMAN No
M4K1_HUMAN No
M4K3_HUMAN No
M4K5_HUMAN No
MAAI_HUMAN No
MAP1A_HUMAN No
MED14_HUMAN No
MED28_HUMAN No
MEPE_HUMAN No
MET27_HUMAN No
MINT_HUMAN No
MLXPL_HUMAN No
MP2K5_HUMAN No
MSI2H_HUMAN No
MTAP2_HUMAN No
MUC1_HUMAN No
MUC24_HUMAN No
MY18A_HUMAN No
MYG1_HUMAN No
MYH11_HUMAN No
MYH9_HUMAN No
MYLK_HUMAN No
MYOZ1_HUMAN No
MYRIP_HUMAN No
NADK_HUMAN No
NCKP5_HUMAN No
NCKX1_HUMAN No
NEK8_HUMAN No
NELFB_HUMAN No
NFASC_HUMAN No
NFS1_HUMAN No
NFYB_HUMAN No
NKD2_HUMAN No
NKX21_HUMAN No
NP1L5_HUMAN No
NR1H4_HUMAN No
NUCL_HUMAN No
OLIG1_HUMAN No
P2RX7_HUMAN No
P3C2B_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
P85B_HUMAN No
PACRL_HUMAN No
PAK2_HUMAN No
PANX2_HUMAN No
PAR3_HUMAN No
PAR6A_HUMAN No
PAX3_HUMAN No
PBIP1_HUMAN No
PCDB5_HUMAN No
PDC6I_HUMAN Yes: Q8WUM4 (MoonDB)
PDE4D_HUMAN No
PDIA2_HUMAN No
PEX13_HUMAN No
PGFRB_HUMAN No
PHAR2_HUMAN No
PHAR4_HUMAN No
PHC2_HUMAN Yes: Q8IXK0 (MoonDB)
PKHA7_HUMAN No
PKHS1_HUMAN No
PLCG2_HUMAN Yes: P16885 (MoonDB)
PMGE_HUMAN No
PNMA2_HUMAN No
POMP_HUMAN No
PON2_HUMAN No
PP2BA_HUMAN No
PP2BB_HUMAN No
PPARA_HUMAN No
PRAP1_HUMAN No
PRC2A_HUMAN No
PRG4_HUMAN No
PRIC3_HUMAN No
PRR22_HUMAN No
PTN11_HUMAN Yes: Q06124 (MoonDB)
PTN22_HUMAN No
PTN23_HUMAN No
PTN4_HUMAN No
PTN6_HUMAN Yes: P29350 (MoonDB)
PTPR2_HUMAN No
Q7Z783_HUMAN No
Q92942_HUMAN No
Q92967_HUMAN No
Q96ID7_HUMAN No
RAB1B_HUMAN No
RAB1C_HUMAN No
RAB6B_HUMAN No
RAB8B_HUMAN No
RAGE_HUMAN No
RB11A_HUMAN No
RBBP6_HUMAN No
RBM33_HUMAN No
RB_HUMAN No
RED_HUMAN No
REPS2_HUMAN No
RET4_HUMAN No
RHG09_HUMAN No
RHG32_HUMAN No
RIF1_HUMAN No
RIMS1_HUMAN No
RIMS2_HUMAN No
RIN3_HUMAN Yes: Q8TB24 (MoonDB)
RIT1_HUMAN No
RIT2_HUMAN No
RL13_HUMAN No
RL40_HUMAN No
RNC_HUMAN No
RNF10_HUMAN No
RP1L1_HUMAN No
RPA2_HUMAN No
RPAC2_HUMAN No
RPB1_HUMAN No
RPGF1_HUMAN No
RPP38_HUMAN No
RRAS_HUMAN No
RUSD2_HUMAN No
RYR1_HUMAN No
S23A1_HUMAN No
SAMP_HUMAN No
SELN_HUMAN No
SEM7A_HUMAN No
SF3A2_HUMAN No
SF3B4_HUMAN No
SH2B1_HUMAN No
SH319_HUMAN No
SHAN2_HUMAN No
SHAN3_HUMAN No
SHBG_HUMAN Yes: P04278 (MoonDB)
SHC1_HUMAN No
SHRM2_HUMAN No
SLX1_HUMAN No
SMAD3_HUMAN Yes: P84022 (MoonDB)
SMRC1_HUMAN No
SMRC2_HUMAN No
SMRD1_HUMAN No
SMRD2_HUMAN No
SMRD3_HUMAN No
SNPC3_HUMAN No
SNX12_HUMAN No
SNX17_HUMAN No
SNX3_HUMAN No
SNX7_HUMAN No
SNX8_HUMAN No
SO2A1_HUMAN No
SOCS4_HUMAN No
SOCS7_HUMAN No
SOS1_HUMAN No
SOS2_HUMAN No
SP1_HUMAN No
SPTB2_HUMAN No
SPY2_HUMAN No
SREC2_HUMAN No
SRGP3_HUMAN No
SSXT_HUMAN No
ST32C_HUMAN No
STABP_HUMAN No
STF1_HUMAN No
STRAB_HUMAN No
SUV92_HUMAN No
SYDC_HUMAN No
SYNJ2_HUMAN No
TARSH_HUMAN No
TBC3B_HUMAN No
TCAL8_HUMAN No
TCRG1_HUMAN No
TERA_HUMAN Yes: P55072 (MoonDB)
TFG_HUMAN Yes: Q92734 (MoonDB)
TGON2_HUMAN No
THMS1_HUMAN No
TM128_HUMAN No
TNPO1_HUMAN No
TNR14_HUMAN No
TPX2_HUMAN No
TRAIP_HUMAN No
TRFE_HUMAN No
TRY1_HUMAN No
TSC2_HUMAN No
TSKS_HUMAN No
TSN2_HUMAN No
TULP1_HUMAN No
TXK_HUMAN No
TYRO3_HUMAN No
U520_HUMAN No
UBA1_HUMAN No
UBC_HUMAN Yes: P0CG48 (MoonDB)
UBP53_HUMAN No
UFO_HUMAN No
UGPA_HUMAN No
UQCC2_HUMAN No
VAV3_HUMAN No
VAV_HUMAN No
VIME_HUMAN Yes: P08670 (MoonDB)
VP13A_HUMAN No
VTDB_HUMAN No
WASL_HUMAN No
WBP11_HUMAN No
WDFY3_HUMAN No
WDR1_HUMAN No
WDR44_HUMAN No
WIPF1_HUMAN No
WIPF2_HUMAN No
YLPM1_HUMAN No
ZBT12_HUMAN No
ZBT7B_HUMAN No
ZKSC3_HUMAN No
ZMAT1_HUMAN No
ZN274_HUMAN No
ZN311_HUMAN No
ZN341_HUMAN No
ZNF32_HUMAN No
ZNF7_HUMAN No
PMID Article Title
1322798 The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
1384039 Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.
7664271 Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.
7716522 Crystal structure of the mammalian Grb2 adaptor.
7881903 Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
8178156 Cloning of a Grb2 isoform with apoptotic properties.
8262059 Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.
8388384 Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.
8491186 The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
8723348 Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.
8794768 Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain.
8798570 Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
9062191 A family of proteins that inhibit signalling through tyrosine kinase receptors.
9108392 Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.
9148935 Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.
9178760 Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
9233773 Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.
9422736 Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.
9484780 Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.
9489702 LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
9553137 Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.
9642078 Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands.
10022120 Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.
10026169 Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
10051406 The gene structure of the human growth factor bound protein GRB2.
10086340 cbl-b inhibits epidermal growth factor receptor signaling.
10090780 Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).
10318918 NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.
10395476 Structure-based design, synthesis, and X-ray crystallography of a high- affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.
10747847 Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.
10867024 Ligand discrimination in signaling through an ErbB4 receptor homodimer.
10942756 Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.
10980613 Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control.
11063574 Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.
11433379 Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).
11518702 The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.
11533253 Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2.
11827484 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
11912194 Insulin receptor substrate 4 associates with the protein IRAS.
12171928 SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation.
12359715 Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.
12475979 Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.
12486104 Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
12514734 LAB: a new membrane-associated adaptor molecule in B cell activation.
12925710 EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
15102829 Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.
15302586 The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
15488758 TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15526160 Signal transduction via the stem cell factor receptor/c-Kit.
16129412 Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
16582911 NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18296648 Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.
18559951 Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
18669648 A quantitative atlas of mitotic phosphorylation.
19509291 GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.
19523899 Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19815557 Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
19836242 An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.
19914172 KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
20521079 Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells.
20933011 FCRL6 receptor: expression and associated proteins.
21179510 Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.
21269460 Initial characterization of the human central proteome.
21930792 SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.
22027826 ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration.
22561606 Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23946459 Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.
24098653 High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.
25944712 N-terminome analysis of the human mitochondrial proteome.
27041574 PRR14 is a novel activator of the PI3K pathway promoting lung carcinogenesis.
No results found.
Domain Name Domain ID Source
A43321 A43321 PIR
SH2 IPR000980 InterPro
SH3_domain IPR001452 InterPro
Grb2 IPR030219 InterPro
GRB2_N_SH3 IPR035641 InterPro
GRB2_C_SH3 IPR035643 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
PTHR24418:SF290 PTHR24418:SF290 PANTHER
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SH3_GRB2_N cd11946 CDD
SH3_GRB2_C cd11949 CDD