Protein: O15360 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O15360 (Uniprot)	FANCA_HUMAN	FANCA	Fanconi anemia group A protein	human	No

Protein Function

Uniprot: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35	5.53e-55	9.57e-64
GO:0007166	cell surface receptor signaling pathway	108	GO:0006139	nucleobase-containing compound metabolic process	462	6.88e-41	1.21e-84

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
29	GO:0060255	regulation of macromolecule metabolic process
29	GO:0007165	signal transduction
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
29	GO:0005634	nucleus
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
202	GO:0005829	cytosol
202	GO:0005886	plasma membrane
462	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006281	DNA repair	TAS
GO:0006461	protein complex assembly	TAS
GO:0007140	male meiotic nuclear division	IEA
GO:0008584	male gonad development	IEA
GO:0008585	female gonad development	IEA
GO:0036297	interstrand cross-link repair	TAS
GO:0042127	regulation of cell proliferation	IEA
GO:0045589	regulation of regulatory T cell differentiation	IEA
GO:0050727	regulation of inflammatory response	IEA
GO:0051090	regulation of DNA binding transcription factor activity	IEA

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IEA
GO:0043240	Fanconi anaemia nuclear complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AKT1_HUMAN	No
ALDOA_HUMAN	No
ATPB_HUMAN	No
AZIN1_HUMAN	No
BRCA1_HUMAN	No
CAN1_HUMAN	No
CD79A_HUMAN	No
CENPE_HUMAN	No
CRK_HUMAN	Yes: P46108 (MoonDB)
DAXX_HUMAN	No

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Publications Associated

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PMID	Article Title
8896563	Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA.
9169126	The genomic organization of the Fanconi anemia group A (FAA) gene.
9371798	Sequence variation in the Fanconi anemia gene FAA.
9399890	Mutations of the Fanconi anemia group A gene (FAA) in Italian patients.
9711872	Identification of Alu-mediated deletions in the Fanconi anemia gene FAA.
9721219	Fine exon-intron structure of the Fanconi anemia group A (FAA) gene and characterization of two genomic deletions.
9742112	Functional activity of the Fanconi anemia protein FAA requires FAC binding and nuclear localization.
9789045	The Fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation.
9929978	Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients.
10094191	Heterogeneous spectrum of mutations in the Fanconi anaemia group A gene.

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OMIM Diseases Associated

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OMIM ID	Disease Name
227650	Fanconi anemia, complementation group A

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Protein Domains Associated

Showing 1 to 6 of 6 entries

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Domain Name	Domain ID	Source
FANCA	IPR003516	InterPro
Fanconi_A	PF03511	Pfam
Fanconi_A_N	IPR031729	InterPro
Fanconi_A_N	PF15865	Pfam
FANCONIAGENE	PR00826	PRINTS
T02755	T02755	PIR

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