Protein: O15360

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O15360 (Uniprot) FANCA_HUMAN FANCA Fanconi anemia group A protein human No
Uniprot: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 462 6.88e-41 1.21e-84
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
462 GO:0090304 nucleic acid metabolic process
617 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
29 GO:0005634 nucleus
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
462 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006281 DNA repair TAS
GO:0006461 protein complex assembly TAS
GO:0007140 male meiotic nuclear division IEA
GO:0008584 male gonad development IEA
GO:0008585 female gonad development IEA
GO:0036297 interstrand cross-link repair TAS
GO:0042127 regulation of cell proliferation IEA
GO:0045589 regulation of regulatory T cell differentiation IEA
GO:0050727 regulation of inflammatory response IEA
GO:0051090 regulation of DNA binding transcription factor activity IEA
GO:2000348 regulation of CD40 signaling pathway IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IEA
GO:0043240 Fanconi anaemia nuclear complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8896563 Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA.
9169126 The genomic organization of the Fanconi anemia group A (FAA) gene.
9371798 Sequence variation in the Fanconi anemia gene FAA.
9399890 Mutations of the Fanconi anemia group A gene (FAA) in Italian patients.
9711872 Identification of Alu-mediated deletions in the Fanconi anemia gene FAA.
9721219 Fine exon-intron structure of the Fanconi anemia group A (FAA) gene and characterization of two genomic deletions.
9742112 Functional activity of the Fanconi anemia protein FAA requires FAC binding and nuclear localization.
9789045 The Fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation.
9929978 Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients.
10094191 Heterogeneous spectrum of mutations in the Fanconi anaemia group A gene.
10210316 A patient-derived mutant form of the Fanconi anemia protein, FANCA, is defective in nuclear accumulation.
10521298 High frequency of large intragenic deletions in the Fanconi anemia group A gene.
10807541 Novel mutations of the FANCG gene causing alternative splicing in Japanese Fanconi anemia.
11091222 Fanconi anaemia group A (FANCA) mutations in Israeli non-Ashkenazi Jewish patients.
12724401 A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15299030 The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15502827 X-linked inheritance of Fanconi anemia complementation group B.
15616553 The sequence and analysis of duplication-rich human chromosome 16.
16116422 A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17924555 Genetic subtyping of Fanconi anemia by comprehensive mutation screening.
18550849 HES1 is a novel interactor of the Fanconi anemia core complex.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18987736 DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
22266823 Regulation of Rev1 by the Fanconi anemia core complex.
22343915 FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.
22705371 A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
OMIM ID Disease Name
227650 Fanconi anemia, complementation group A
Domain Name Domain ID Source
FANCA IPR003516 InterPro
Fanconi_A_N IPR031729 InterPro
Fanconi_A PF03511 Pfam
Fanconi_A_N PF15865 Pfam
FANCONIAGENE PR00826 PRINTS
T02755 T02755 PIR