Protein: P06733 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P06733 (Uniprot)	ENOA_HUMAN	ENO1	Alpha-enolase	human	No

Protein Function

Uniprot: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	308	GO:0034641	cellular nitrogen compound metabolic process	35	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
25	GO:0006464	cellular protein modification process
25	GO:0010467	gene expression
25	GO:0060255	regulation of macromolecule metabolic process
25	GO:0007165	signal transduction
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
214	GO:0044267	cellular protein metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
25	GO:0005829	cytosol
25	GO:0005634	nucleus
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
214	GO:0044428	nuclear part
308	GO:0005829	cytosol
308	GO:0070013	intracellular organelle lumen
308	GO:0044428	nuclear part
308	GO:0005886	plasma membrane

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0006094	gluconeogenesis	TAS
GO:0006351	transcription, DNA-templated	IEA
GO:0009615	response to virus	IEP
GO:0010756	positive regulation of plasminogen activation	IMP
GO:0030308	negative regulation of cell growth	IDA
GO:0045892	negative regulation of transcription, DNA-templated	IMP
GO:0045933	positive regulation of muscle contraction	IGI
GO:0061621	canonical glycolysis	TAS
GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IGI

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000015	phosphopyruvate hydratase complex	IDA
GO:0005615	extracellular space	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0009986	cell surface	IDA
GO:0016020	membrane	IDA
GO:0031430	M band	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005615	extracellular space	GO:0005634	nucleus	6.26e-54	1.10e-77
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0009986	cell surface	1.10e-44	1.49e-81
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005829	cytosol	GO:0009986	cell surface	3.26e-22	6.81e-06

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433Z_HUMAN	Yes: P63104 (MoonDB)
2A5E_HUMAN	No
ACES_HUMAN	No
ACTB_HUMAN	No
ALDOA_HUMAN	No
AMBP_HUMAN	No
ARI1B_HUMAN	No
BCL6_HUMAN	No
BHE40_HUMAN	Yes: O14503 (MoonDB)
BRCA1_HUMAN	No

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Publications Associated

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PMID	Article Title
1369209	Purification and characterization of immunoglobulin production stimulating factor-II beta derived from Namalwa cells.
2005901	Cloning and characterization of a human c-myc promoter-binding protein.
2373081	Structure of the human gene for alpha-enolase.
3529090	Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase.
7787969	Induced expression of alpha-enolase in differentiated diffuse large cell lymphoma.
8824716	Autoreactive epitopes within the human alpha-enolase and their recognition by sera from patients with endometriosis.
9110174	Large-scale concatenation cDNA sequencing.
9150948	A two-dimensional gel database of human colon carcinoma proteins.
9308760	Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display.
9653645	Molecular cloning and expression analysis of five novel genes in chromosome 1p36.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
A29170	S11696	PIR
A39579	A39579	PIR
eno	TIGR01060	TIGRFAMs
Enolase	IPR000941	InterPro
Enolase	MF_00318	HAMAP
Enolase	PIRSF001400	PIRSF
ENOLASE	PR00148	PRINTS
ENOLASE	PS00164	PROSITE
enolase	SFLDG00178	SFLD
Enolase	SFLDS00001	SFLD

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