Protein: P06733

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P06733 (Uniprot) ENOA_HUMAN ENO1 Alpha-enolase human No
Uniprot: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 308 GO:0034641 cellular nitrogen compound metabolic process 35 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
25 GO:0006464 cellular protein modification process
25 GO:0010467 gene expression
25 GO:0060255 regulation of macromolecule metabolic process
25 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
214 GO:0044267 cellular protein metabolic process
214 GO:0006355 regulation of transcription, DNA-templated
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
545 GO:0044267 cellular protein metabolic process
545 GO:0006139 nucleobase-containing compound metabolic process
564 GO:0016070 RNA metabolic process
564 GO:0034645 cellular macromolecule biosynthetic process
564 GO:0044271 cellular nitrogen compound biosynthetic process
564 GO:0044267 cellular protein metabolic process
564 GO:0009892 negative regulation of metabolic process
564 GO:0010468 regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
25 GO:0005829 cytosol
25 GO:0005634 nucleus
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
214 GO:0044428 nuclear part
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
346 GO:0043232 intracellular non-membrane-bounded organelle
346 GO:0005634 nucleus
545 GO:0005829 cytosol
545 GO:0005634 nucleus
545 GO:0031982 vesicle
564 GO:0005829 cytosol
564 GO:0070013 intracellular organelle lumen
564 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0006094 gluconeogenesis TAS
GO:0006351 transcription, DNA-templated IEA
GO:0009615 response to virus IEP
GO:0010756 positive regulation of plasminogen activation IMP
GO:0030308 negative regulation of cell growth IDA
GO:0045892 negative regulation of transcription, DNA-templated IMP
GO:0045933 positive regulation of muscle contraction IGI
GO:0061621 canonical glycolysis TAS
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IGI
GO:2001171 positive regulation of ATP biosynthetic process IGI
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000015 phosphopyruvate hydratase complex IDA
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IDA
GO:0009986 cell surface IDA
GO:0016020 membrane IDA
GO:0031430 M band IEA
GO:0070062 extracellular exosome IDA
GO:0099738 cell cortex region IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0009986 cell surface 1.10e-44 1.49e-81
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005829 cytosol GO:0009986 cell surface 3.26e-22 6.81e-06
PMID Article Title
1369209 Purification and characterization of immunoglobulin production stimulating factor-II beta derived from Namalwa cells.
2005901 Cloning and characterization of a human c-myc promoter-binding protein.
2373081 Structure of the human gene for alpha-enolase.
3529090 Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase.
7787969 Induced expression of alpha-enolase in differentiated diffuse large cell lymphoma.
8824716 Autoreactive epitopes within the human alpha-enolase and their recognition by sera from patients with endometriosis.
9110174 Large-scale concatenation cDNA sequencing.
9150948 A two-dimensional gel database of human colon carcinoma proteins.
9308760 Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display.
9653645 Molecular cloning and expression analysis of five novel genes in chromosome 1p36.
9878089 Anti-enolase-alpha autoantibodies in cancer-associated retinopathy: epitope mapping and cytotoxicity on retinal cells.
10082554 Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation.
10681589 Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene.
10802057 ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1).
11134351 A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.
11497239 Multifunctional alpha-enolase: its role in diseases.
12297304 Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy.
12666133 Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-enolase.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
16139798 Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
16548883 Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
16710414 The DNA sequence and biological annotation of human chromosome 1.
16815975 HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.
17974005 The full-ORF clone resource of the German cDNA consortium.
18560153 Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme.
18669648 A quantitative atlas of mitotic phosphorylation.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21908771 The first identification of lysine malonylation substrates and its regulatory enzyme.
22905912 Resveratrol-induced changes of the human adipocyte secretion profile.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
A39579 A39579 PIR
Enolase IPR000941 InterPro
Enolase_CS IPR020809 InterPro
Enolase_C IPR020810 InterPro
Enolase_N IPR020811 InterPro
Enolase-like_N IPR029017 InterPro
Enolase-like_superfamily IPR034390 InterPro
Enolase-like_C IPR036849 InterPro
Enolase MF_00318 HAMAP
Enolase_C PF00113 Pfam
Enolase_N PF03952 Pfam
Enolase PIRSF001400 PIRSF
ENOLASE PR00148 PRINTS
ENOLASE PS00164 PROSITE
PTHR11902 PTHR11902 PANTHER
A29170 S11696 PIR
enolase SFLDG00178 SFLD
Enolase SFLDS00001 SFLD
Enolase_C SM01192 SMART
Enolase_N SM01193 SMART
SSF51604 SSF51604 SUPFAM
SSF54826 SSF54826 SUPFAM
eno TIGR01060 TIGRFAMs
enolase cd03313 CDD