Protein: P63104

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P63104 (Uniprot) 1433Z_HUMAN YWHAZ 14-3-3 protein zeta/delta human No
Uniprot: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1, 4, 187, 282, 308 GO:0006725 cellular aromatic compound metabolic process 484 5.44e-126 5.27e-27
GO:0043170 macromolecule metabolic process 310, 367 GO:0033036 macromolecule localization 517 2.48e-08 1.95e-27
GO:0009059 macromolecule biosynthetic process 471 GO:0033036 macromolecule localization 517 2.32e-08 6.09e-30
GO:0006725 cellular aromatic compound metabolic process 484 GO:0033036 macromolecule localization 517 1.29e-20 6.46e-74
GO:0033036 macromolecule localization 517 GO:0044260 cellular macromolecule metabolic process 544, 724 4.56e-06 3.25e-28
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
2 GO:0044267 cellular protein metabolic process
2 GO:0010467 gene expression
2 GO:0006139 nucleobase-containing compound metabolic process
2 GO:0060255 regulation of macromolecule metabolic process
2 GO:0007165 signal transduction
4 GO:0035556 intracellular signal transduction
4 GO:0031399 regulation of protein modification process
4 GO:0009966 regulation of signal transduction
7 GO:0031324 negative regulation of cellular metabolic process
7 GO:0010605 negative regulation of macromolecule metabolic process
7 GO:0051172 negative regulation of nitrogen compound metabolic process
7 GO:0010604 positive regulation of macromolecule metabolic process
7 GO:0006357 regulation of transcription from RNA polymerase II promoter
37 GO:0007165 signal transduction
123 GO:0006464 cellular protein modification process
123 GO:0006355 regulation of transcription, DNA-templated
172 GO:0060255 regulation of macromolecule metabolic process
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
249 GO:0060255 regulation of macromolecule metabolic process
275 GO:0022607 cellular component assembly
275 GO:0006796 phosphate-containing compound metabolic process
275 GO:0060255 regulation of macromolecule metabolic process
275 GO:0007165 signal transduction
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
310 GO:0019538 protein metabolic process
367 GO:0010467 gene expression
367 GO:0007399 nervous system development
367 GO:0006139 nucleobase-containing compound metabolic process
367 GO:0019538 protein metabolic process
367 GO:0051128 regulation of cellular component organization
367 GO:0060255 regulation of macromolecule metabolic process
367 GO:0007165 signal transduction
471 GO:0034645 cellular macromolecule biosynthetic process
471 GO:0044271 cellular nitrogen compound biosynthetic process
471 GO:0006464 cellular protein modification process
471 GO:0031324 negative regulation of cellular metabolic process
471 GO:0010605 negative regulation of macromolecule metabolic process
471 GO:0010604 positive regulation of macromolecule metabolic process
471 GO:0051173 positive regulation of nitrogen compound metabolic process
471 GO:0051252 regulation of RNA metabolic process
471 GO:0010468 regulation of gene expression
471 GO:0007165 signal transduction
484 GO:0006139 nucleobase-containing compound metabolic process
484 GO:1901362 organic cyclic compound biosynthetic process
484 GO:0019538 protein metabolic process
484 GO:0060255 regulation of macromolecule metabolic process
484 GO:0007165 signal transduction
512 GO:0035556 intracellular signal transduction
512 GO:0006468 protein phosphorylation
512 GO:0060255 regulation of macromolecule metabolic process
513 GO:0007165 signal transduction
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
544 GO:0016070 RNA metabolic process
544 GO:0006464 cellular protein modification process
544 GO:0006796 phosphate-containing compound metabolic process
544 GO:0031325 positive regulation of cellular metabolic process
544 GO:0010604 positive regulation of macromolecule metabolic process
544 GO:0051173 positive regulation of nitrogen compound metabolic process
544 GO:0032268 regulation of cellular protein metabolic process
544 GO:0010468 regulation of gene expression
544 GO:0023051 regulation of signaling
544 GO:0007165 signal transduction
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
555 GO:0006464 cellular protein modification process
555 GO:0060255 regulation of macromolecule metabolic process
555 GO:0007165 signal transduction
652 GO:0044267 cellular protein metabolic process
652 GO:0060255 regulation of macromolecule metabolic process
696 GO:0022607 cellular component assembly
696 GO:0006464 cellular protein modification process
696 GO:0060255 regulation of macromolecule metabolic process
696 GO:0007165 signal transduction
704 GO:0007165 signal transduction
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
724 GO:0016070 RNA metabolic process
724 GO:0035556 intracellular signal transduction
724 GO:0009892 negative regulation of metabolic process
724 GO:0034654 nucleobase-containing compound biosynthetic process
724 GO:0006468 protein phosphorylation
724 GO:2000112 regulation of cellular macromolecule biosynthetic process
724 GO:0032268 regulation of cellular protein metabolic process
724 GO:0010468 regulation of gene expression
724 GO:0019219 regulation of nucleobase-containing compound metabolic process
775 GO:0044267 cellular protein metabolic process
775 GO:0010467 gene expression
775 GO:0006139 nucleobase-containing compound metabolic process
775 GO:0060255 regulation of macromolecule metabolic process
792 GO:0060255 regulation of macromolecule metabolic process
835 GO:0022607 cellular component assembly
835 GO:0051640 organelle localization
836 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
2 GO:0005829 cytosol
2 GO:0005634 nucleus
4 GO:0005829 cytosol
4 GO:0005634 nucleus
7 GO:0005654 nucleoplasm
11 GO:0005634 nucleus
37 GO:0005829 cytosol
123 GO:0043232 intracellular non-membrane-bounded organelle
123 GO:0005654 nucleoplasm
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
249 GO:0005829 cytosol
249 GO:0005634 nucleus
249 GO:0031982 vesicle
275 GO:0043232 intracellular non-membrane-bounded organelle
275 GO:0005634 nucleus
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
291 GO:0043232 intracellular non-membrane-bounded organelle
291 GO:0005634 nucleus
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
310 GO:0005829 cytosol
310 GO:0005634 nucleus
367 GO:0005829 cytosol
367 GO:0070013 intracellular organelle lumen
367 GO:0005634 nucleus
471 GO:0005654 nucleoplasm
484 GO:0070013 intracellular organelle lumen
484 GO:0005634 nucleus
501 GO:0031090 organelle membrane
502 GO:0005829 cytosol
502 GO:0031981 nuclear lumen
512 GO:0005829 cytosol
513 GO:0005829 cytosol
513 GO:0005634 nucleus
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
544 GO:0005829 cytosol
544 GO:0005634 nucleus
549 GO:0005829 cytosol
549 GO:0005634 nucleus
555 GO:0005634 nucleus
652 GO:0005829 cytosol
652 GO:0005634 nucleus
652 GO:0031982 vesicle
696 GO:0005829 cytosol
696 GO:0043232 intracellular non-membrane-bounded organelle
696 GO:0005634 nucleus
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
724 GO:0005829 cytosol
724 GO:0070013 intracellular organelle lumen
724 GO:0005634 nucleus
775 GO:0005829 cytosol
775 GO:0005634 nucleus
792 GO:0005829 cytosol
835 GO:0044430 cytoskeletal part
835 GO:0005829 cytosol
835 GO:0015630 microtubule cytoskeleton
835 GO:0005654 nucleoplasm
836 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006605 protein targeting IEA
GO:0007165 signal transduction TAS
GO:0030168 platelet activation TAS
GO:0043066 negative regulation of apoptotic process TAS
GO:0043488 regulation of mRNA stability TAS
GO:0051683 establishment of Golgi localization IMP
GO:0061024 membrane organization TAS
GO:0090168 Golgi reassembly IMP
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm TAS
GO:0005739 mitochondrion IEA
GO:0005829 cytosol TAS
GO:0005925 focal adhesion IDA
GO:0030659 cytoplasmic vesicle membrane TAS
GO:0031982 vesicle IDA
GO:0042470 melanosome IEA
GO:0070062 extracellular exosome IDA
GO:0072562 blood microparticle IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005615 extracellular space GO:0005654 nucleoplasm 1.00e-49 3.88e-77
GO:0005634 nucleus GO:0030659 cytoplasmic vesicle membrane 4.71e-30 7.28e-80
GO:0005634 nucleus GO:0031982 vesicle 1.94e-54 3.27e-93
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0030659 cytoplasmic vesicle membrane 1.28e-24 2.03e-103
GO:0005654 nucleoplasm GO:0031982 vesicle 4.01e-60 1.21e-165
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
GPSM3_HUMAN No
CC125_HUMAN No
ATX1_HUMAN Yes: P54253 (MoonDB)
TFCP2_HUMAN No
XRCC6_HUMAN Yes: P12956 (MoonDB)
UBE3A_HUMAN Yes: Q05086 (MoonDB)
SNAPN_HUMAN No
HDAC4_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
HSPB1_HUMAN Yes: P04792 (MoonDB)
EGFR_HUMAN Yes: P00533 (MoonDB)
LRRK2_HUMAN No
SRBS2_HUMAN No
SH3G1_HUMAN No
TSC1_HUMAN No
1433E_HUMAN Yes: P62258 (MoonDB)
K0232_HUMAN No
CENPJ_HUMAN No
ADIP_HUMAN Yes: Q9Y2D8 (MoonDB)
STK25_HUMAN No
M3K20_HUMAN No
ZN839_HUMAN No
WNK1_HUMAN Yes: Q9H4A3 (MoonDB)
RAF1_HUMAN Yes: P04049 (MoonDB)
MTR1A_HUMAN No
RGS3_HUMAN No
H31_HUMAN No
TERA_HUMAN Yes: P55072 (MoonDB)
CDK16_HUMAN No
GBRL2_HUMAN Yes: P60520 (MoonDB)
PIAS1_HUMAN No
TAU_HUMAN No
TSC2_HUMAN No
CE126_HUMAN No
BAIP2_HUMAN No
CBL_HUMAN No
RPR1A_HUMAN No
ADA22_HUMAN No
ADA23_HUMAN No
ANM5_HUMAN No
ARAF_HUMAN No
BAD_HUMAN No
BCAR1_HUMAN No
CAF1A_HUMAN No
CDC5L_HUMAN No
CGNL1_HUMAN No
CSN5_HUMAN No
DISC1_HUMAN Yes: Q9NRI5 (MoonDB)
E41L2_HUMAN No
EFNB3_HUMAN No
EIF3A_HUMAN No
ENOA_HUMAN Yes: P06733 (MoonDB)
EXO1_HUMAN No
FA13B_HUMAN No
FA53C_HUMAN No
FHOD1_HUMAN No
GCH1_HUMAN No
GP1BA_HUMAN Yes: P07359 (MoonDB)
GP1BB_HUMAN No
HDAC9_HUMAN No
IL9R_HUMAN No
KAPCA_HUMAN No
KIF1C_HUMAN No
KIF23_HUMAN No
KLF11_HUMAN No
KPCE_HUMAN No
LCP2_HUMAN No
LIMK1_HUMAN No
LRMP_HUMAN No
M3K4_HUMAN No
M3K5_HUMAN No
MADD_HUMAN No
MARK2_HUMAN No
MARK3_HUMAN No
MEF2C_HUMAN No
MP2K5_HUMAN No
MPIP1_HUMAN No
MPIP2_HUMAN No
MPP9_HUMAN No
MSL2_HUMAN No
MYH9_HUMAN No
NED4L_HUMAN No
PAK1_HUMAN Yes: Q13153 (MoonDB)
PPR3D_HUMAN No
PRDX2_HUMAN No
PTN3_HUMAN No
PTPRO_HUMAN No
RAP1A_HUMAN No
RASL3_HUMAN No
REM1_HUMAN No
RIPR2_HUMAN No
RMD3_HUMAN No
RND3_HUMAN No
RPGP2_HUMAN No
SIMC1_HUMAN No
SNAT_HUMAN No
SNX24_HUMAN No
SSFA2_HUMAN No
SYN2_HUMAN No
SYNP2_HUMAN No
SYNPO_HUMAN No
TA2R_HUMAN No
TAB2_HUMAN No
TENS1_HUMAN No
TERT_HUMAN No
TNAP3_HUMAN No
TPD53_HUMAN No
TY3H_HUMAN No
UCP2_HUMAN No
UCP3_HUMAN No
WEE1_HUMAN No
WNK2_HUMAN No
WWTR1_HUMAN No
YAP1_HUMAN No
ZEP2_HUMAN No
PMID Article Title
1577711 Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis.
9360956 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.
9512661 Two unique 5' untranslated regions in mRNAs encoding human 14-3-3 zeta: differential expression in hemopoietic cells.
10455159 Nuclear localization of protein kinase U-alpha is regulated by 14-3-3.
10488331 Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
11336675 Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
11427721 Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.
11956222 Identification of 14-3-3zeta as a protein kinase B/Akt substrate.
12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12865427 The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface.
14578935 Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14970201 p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
15071501 JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.
15159416 A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15644438 Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205.
15660133 Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.
15696159 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
15883165 Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism.
16114898 14-3-3 protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4.
16246723 Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
16376338 Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
17081065 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17235285 Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis.
17913709 Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19172738 Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19640509 SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23572552 ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
26047703 Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.
No results found.
Domain Name Domain ID Source
PSHUAM A38246 PIR
14-3-3 IPR000308 InterPro
14-3-3_CS IPR023409 InterPro
14-3-3_domain IPR023410 InterPro
14-3-3_dom_sf IPR036815 InterPro
14-3-3 PF00244 Pfam
14-3-3 PIRSF000868 PIRSF
1433ZETA PR00305 PRINTS
1433_1 PS00796 PROSITE
1433_2 PS00797 PROSITE
PTHR18860 PTHR18860 PANTHER
14_3_3 SM00101 SMART
SSF48445 SSF48445 SUPFAM