Protein: P62258

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P62258 (Uniprot) 1433E_HUMAN YWHAE 14-3-3 protein epsilon human No
Uniprot: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 310 GO:0042886 amide transport 663 2.11e-04 2.73e-69
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
2 GO:0044267 cellular protein metabolic process
2 GO:0010467 gene expression
2 GO:0006139 nucleobase-containing compound metabolic process
2 GO:0060255 regulation of macromolecule metabolic process
2 GO:0007165 signal transduction
3 GO:0022607 cellular component assembly
3 GO:0060255 regulation of macromolecule metabolic process
4 GO:0035556 intracellular signal transduction
4 GO:0031399 regulation of protein modification process
4 GO:0009966 regulation of signal transduction
6 GO:0034645 cellular macromolecule biosynthetic process
6 GO:0010467 gene expression
6 GO:0090304 nucleic acid metabolic process
6 GO:0060255 regulation of macromolecule metabolic process
7 GO:0031324 negative regulation of cellular metabolic process
7 GO:0010605 negative regulation of macromolecule metabolic process
7 GO:0051172 negative regulation of nitrogen compound metabolic process
7 GO:0010604 positive regulation of macromolecule metabolic process
7 GO:0006357 regulation of transcription from RNA polymerase II promoter
123 GO:0006464 cellular protein modification process
123 GO:0006355 regulation of transcription, DNA-templated
172 GO:0060255 regulation of macromolecule metabolic process
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
237 GO:0022607 cellular component assembly
237 GO:0034645 cellular macromolecule biosynthetic process
237 GO:0044271 cellular nitrogen compound biosynthetic process
237 GO:0006464 cellular protein modification process
237 GO:0051649 establishment of localization in cell
237 GO:0010467 gene expression
237 GO:0031324 negative regulation of cellular metabolic process
237 GO:0010605 negative regulation of macromolecule metabolic process
237 GO:0051172 negative regulation of nitrogen compound metabolic process
237 GO:0090304 nucleic acid metabolic process
237 GO:0033365 protein localization to organelle
237 GO:0015031 protein transport
237 GO:0050790 regulation of catalytic activity
237 GO:0051128 regulation of cellular component organization
249 GO:0060255 regulation of macromolecule metabolic process
275 GO:0022607 cellular component assembly
275 GO:0006796 phosphate-containing compound metabolic process
275 GO:0060255 regulation of macromolecule metabolic process
275 GO:0007165 signal transduction
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
310 GO:0019538 protein metabolic process
319 GO:0060255 regulation of macromolecule metabolic process
393 GO:0044267 cellular protein metabolic process
513 GO:0007165 signal transduction
544 GO:0016070 RNA metabolic process
544 GO:0006464 cellular protein modification process
544 GO:0006796 phosphate-containing compound metabolic process
544 GO:0031325 positive regulation of cellular metabolic process
544 GO:0010604 positive regulation of macromolecule metabolic process
544 GO:0051173 positive regulation of nitrogen compound metabolic process
544 GO:0032268 regulation of cellular protein metabolic process
544 GO:0010468 regulation of gene expression
544 GO:0023051 regulation of signaling
544 GO:0007165 signal transduction
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
551 GO:0034645 cellular macromolecule biosynthetic process
551 GO:0090304 nucleic acid metabolic process
551 GO:0034654 nucleobase-containing compound biosynthetic process
551 GO:0010604 positive regulation of macromolecule metabolic process
551 GO:0051173 positive regulation of nitrogen compound metabolic process
652 GO:0044267 cellular protein metabolic process
652 GO:0060255 regulation of macromolecule metabolic process
663 GO:0015833 peptide transport
663 GO:0008104 protein localization
696 GO:0022607 cellular component assembly
696 GO:0006464 cellular protein modification process
696 GO:0060255 regulation of macromolecule metabolic process
696 GO:0007165 signal transduction
704 GO:0007165 signal transduction
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
724 GO:0016070 RNA metabolic process
724 GO:0035556 intracellular signal transduction
724 GO:0009892 negative regulation of metabolic process
724 GO:0034654 nucleobase-containing compound biosynthetic process
724 GO:0006468 protein phosphorylation
724 GO:2000112 regulation of cellular macromolecule biosynthetic process
724 GO:0032268 regulation of cellular protein metabolic process
724 GO:0010468 regulation of gene expression
724 GO:0019219 regulation of nucleobase-containing compound metabolic process
775 GO:0044267 cellular protein metabolic process
775 GO:0010467 gene expression
775 GO:0006139 nucleobase-containing compound metabolic process
775 GO:0060255 regulation of macromolecule metabolic process
836 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
2 GO:0005829 cytosol
2 GO:0005634 nucleus
3 GO:0044430 cytoskeletal part
3 GO:0005829 cytosol
3 GO:0005634 nucleus
4 GO:0005829 cytosol
4 GO:0005634 nucleus
6 GO:0043232 intracellular non-membrane-bounded organelle
6 GO:0005654 nucleoplasm
7 GO:0005654 nucleoplasm
11 GO:0005634 nucleus
123 GO:0043232 intracellular non-membrane-bounded organelle
123 GO:0005654 nucleoplasm
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
237 GO:0005829 cytosol
237 GO:0012505 endomembrane system
237 GO:0005615 extracellular space
237 GO:0043232 intracellular non-membrane-bounded organelle
237 GO:0070013 intracellular organelle lumen
237 GO:0044428 nuclear part
237 GO:0031982 vesicle
249 GO:0005829 cytosol
249 GO:0005634 nucleus
249 GO:0031982 vesicle
275 GO:0043232 intracellular non-membrane-bounded organelle
275 GO:0005634 nucleus
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
291 GO:0043232 intracellular non-membrane-bounded organelle
291 GO:0005634 nucleus
310 GO:0005829 cytosol
310 GO:0005634 nucleus
319 GO:0005829 cytosol
319 GO:0005634 nucleus
393 GO:0043232 intracellular non-membrane-bounded organelle
393 GO:0005634 nucleus
513 GO:0005829 cytosol
513 GO:0005634 nucleus
544 GO:0005829 cytosol
544 GO:0005634 nucleus
549 GO:0005829 cytosol
549 GO:0005634 nucleus
551 GO:0005829 cytosol
551 GO:0005615 extracellular space
551 GO:0043232 intracellular non-membrane-bounded organelle
551 GO:0005654 nucleoplasm
551 GO:0031982 vesicle
652 GO:0005829 cytosol
652 GO:0005634 nucleus
652 GO:0031982 vesicle
663 GO:0005829 cytosol
663 GO:0031982 vesicle
696 GO:0005829 cytosol
696 GO:0043232 intracellular non-membrane-bounded organelle
696 GO:0005634 nucleus
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
724 GO:0005829 cytosol
724 GO:0070013 intracellular organelle lumen
724 GO:0005634 nucleus
775 GO:0005829 cytosol
775 GO:0005634 nucleus
836 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0000165 MAPK cascade IDA
GO:0001764 neuron migration IEA
GO:0003064 regulation of heart rate by hormone NAS
GO:0006605 protein targeting IEA
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
GO:0016032 viral process IEA
GO:0021762 substantia nigra development IEP
GO:0021766 hippocampus development IEA
GO:0021987 cerebral cortex development IEA
GO:0034605 cellular response to heat IDA
GO:0035329 hippo signaling TAS
GO:0035556 intracellular signal transduction TAS
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
GO:0046827 positive regulation of protein export from nucleus IDA
GO:0051480 regulation of cytosolic calcium ion concentration IDA
GO:0060306 regulation of membrane repolarization IDA
GO:0061024 membrane organization TAS
GO:0086013 membrane repolarization during cardiac muscle cell action potential IC
GO:0086091 regulation of heart rate by cardiac conduction IC
GO:0097711 ciliary basal body-plasma membrane docking TAS
GO:1900034 regulation of cellular response to heat TAS
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
GO:1901016 regulation of potassium ion transmembrane transporter activity IDA
GO:1901020 negative regulation of calcium ion transmembrane transporter activity IDA
GO:1902309 negative regulation of peptidyl-serine dephosphorylation IDA
GO:1905913 negative regulation of calcium ion export across plasma membrane IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005739 mitochondrion IEA
GO:0005829 cytosol TAS
GO:0005871 kinesin complex IEA
GO:0005886 plasma membrane IDA
GO:0005925 focal adhesion IDA
GO:0016020 membrane IDA
GO:0030424 axon IEA
GO:0030659 cytoplasmic vesicle membrane TAS
GO:0042470 melanosome IEA
GO:0070062 extracellular exosome IDA
GO:0090724 central region of growth cone IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0030659 cytoplasmic vesicle membrane 4.71e-30 7.28e-80
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
PMID Article Title
2026444 Isolation and partial characterization of the structures of fibroblast activating factor-related proteins from U937 cells.
7644510 14-3-3 proteins associate with cdc25 phosphatases.
8684458 Function of 14-3-3 proteins.
8858348 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region.
10409742 Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
10644344 Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.
11427721 Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.
12042314 Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12917326 Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15696159 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
15722337 Phosphorylation of grb10 regulates its interaction with 14-3-3.
16376338 Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
17081065 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
17085597 Structural basis for protein-protein interactions in the 14-3-3 protein family.
18318008 Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
19172738 Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19592491 Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19640509 SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20417184 Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23572552 ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25588844 Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.
25944712 N-terminome analysis of the human mitochondrial proteome.
26047703 Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.
26055712 Phosphorylation-dependent regulation of Connecdenn/DENND1 guanine nucleotide exchange factors.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
A61235 A61235 PIR
I38947 I38947 PIR
14-3-3 IPR000308 InterPro
14-3-3_CS IPR023409 InterPro
14-3-3_domain IPR023410 InterPro
14-3-3_dom_sf IPR036815 InterPro
14-3-3 PF00244 Pfam
14-3-3 PIRSF000868 PIRSF
1433ZETA PR00305 PRINTS
1433_1 PS00796 PROSITE
1433_2 PS00797 PROSITE
PTHR18860 PTHR18860 PANTHER
14_3_3 SM00101 SMART
SSF48445 SSF48445 SUPFAM