Protein: Q9NRI5

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9NRI5 (Uniprot) DISC1_HUMAN DISC1 Disrupted in schizophrenia 1 protein human No
Uniprot: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1 GO:0006725 cellular aromatic compound metabolic process 222 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
37 GO:0007165 signal transduction
116 GO:0019538 protein metabolic process
116 GO:0060255 regulation of macromolecule metabolic process
222 GO:0006139 nucleobase-containing compound metabolic process
222 GO:0060255 regulation of macromolecule metabolic process
222 GO:0007165 signal transduction
223 GO:0022607 cellular component assembly
223 GO:0007165 signal transduction
244 GO:0006464 cellular protein modification process
244 GO:0060255 regulation of macromolecule metabolic process
244 GO:0007165 signal transduction
248 GO:0044267 cellular protein metabolic process
248 GO:0045893 positive regulation of transcription, DNA-templated
248 GO:0051246 regulation of protein metabolic process
248 GO:0007165 signal transduction
432 GO:0007165 signal transduction
469 GO:0060255 regulation of macromolecule metabolic process
536 GO:0010604 positive regulation of macromolecule metabolic process
536 GO:0051173 positive regulation of nitrogen compound metabolic process
536 GO:0019538 protein metabolic process
536 GO:0007165 signal transduction
583 GO:0060255 regulation of macromolecule metabolic process
603 GO:0060255 regulation of macromolecule metabolic process
665 GO:0044267 cellular protein metabolic process
756 GO:0007165 signal transduction
776 GO:0006464 cellular protein modification process
776 GO:0035556 intracellular signal transduction
776 GO:0031325 positive regulation of cellular metabolic process
776 GO:0032268 regulation of cellular protein metabolic process
776 GO:0009966 regulation of signal transduction
787 GO:0016070 RNA metabolic process
787 GO:0010467 gene expression
787 GO:0060255 regulation of macromolecule metabolic process
787 GO:0007165 signal transduction
826 GO:0022607 cellular component assembly
826 GO:0044267 cellular protein metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
37 GO:0005829 cytosol
50 GO:0005829 cytosol
50 GO:0005634 nucleus
84 GO:0005634 nucleus
92 GO:0005634 nucleus
116 GO:0005829 cytosol
116 GO:0070013 intracellular organelle lumen
116 GO:0005634 nucleus
136 GO:0005829 cytosol
136 GO:0005634 nucleus
140 GO:0043232 intracellular non-membrane-bounded organelle
222 GO:0070013 intracellular organelle lumen
222 GO:0044428 nuclear part
223 GO:0005634 nucleus
227 GO:0005634 nucleus
232 GO:0005829 cytosol
232 GO:0043232 intracellular non-membrane-bounded organelle
244 GO:0005829 cytosol
244 GO:0043232 intracellular non-membrane-bounded organelle
248 GO:0031981 nuclear lumen
432 GO:0005829 cytosol
432 GO:0005886 plasma membrane
447 GO:0005829 cytosol
447 GO:0043232 intracellular non-membrane-bounded organelle
447 GO:0005634 nucleus
469 GO:0043232 intracellular non-membrane-bounded organelle
469 GO:0005634 nucleus
536 GO:0005829 cytosol
536 GO:0005634 nucleus
556 GO:0005829 cytosol
556 GO:0031982 vesicle
583 GO:0043232 intracellular non-membrane-bounded organelle
583 GO:0005634 nucleus
603 GO:0005634 nucleus
631 GO:0044430 cytoskeletal part
631 GO:0005829 cytosol
631 GO:0015630 microtubule cytoskeleton
665 GO:0043232 intracellular non-membrane-bounded organelle
665 GO:0005634 nucleus
756 GO:0005576 extracellular region
756 GO:0005886 plasma membrane
756 GO:0031982 vesicle
776 GO:0005829 cytosol
776 GO:0043232 intracellular non-membrane-bounded organelle
776 GO:0005634 nucleus
787 GO:0005634 nucleus
812 GO:0005634 nucleus
826 GO:0005829 cytosol
826 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000226 microtubule cytoskeleton organization IMP
GO:0001764 neuron migration IMP
GO:0001954 positive regulation of cell-matrix adhesion IEA
GO:0002052 positive regulation of neuroblast proliferation IGI
GO:0021846 cell proliferation in forebrain IEA
GO:0021852 pyramidal neuron migration IEA
GO:0030177 positive regulation of Wnt signaling pathway IGI
GO:0031929 TOR signaling IEA
GO:0032091 negative regulation of protein binding ISS
GO:0045773 positive regulation of axon extension IEA
GO:0051560 mitochondrial calcium ion homeostasis IEA
GO:0051602 response to electrical stimulus IEA
GO:0051966 regulation of synaptic transmission, glutamatergic IEA
GO:0060070 canonical Wnt signaling pathway IEA
GO:0060998 regulation of dendritic spine development IEA
GO:0071539 protein localization to centrosome IEA
GO:0090128 regulation of synapse maturation IEA
GO:1905515 non-motile cilium assembly IMP
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IEA
GO:0005739 mitochondrion IDA
GO:0005783 endoplasmic reticulum IEA
GO:0005813 centrosome IDA
GO:0005829 cytosol IEA
GO:0005871 kinesin complex IEA
GO:0005874 microtubule IEA
GO:0008021 synaptic vesicle IEA
GO:0014069 postsynaptic density IEA
GO:0030054 cell junction IEA
GO:0030286 dynein complex IEA
GO:0030424 axon IEA
GO:0036064 ciliary basal body IEA
GO:0044297 cell body IEA
GO:0045211 postsynaptic membrane IEA
GO:0048471 perinuclear region of cytoplasm IEA
GO:0090724 central region of growth cone IEA
GO:0097546 ciliary base IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 8.26e-33 3.22e-89
GO:0005634 nucleus GO:0008021 synaptic vesicle 1.32e-02 8.03e-21
GO:0005634 nucleus GO:0045211 postsynaptic membrane 4.18e-05 1.09e-18
GO:0005783 endoplasmic reticulum GO:0005813 centrosome 5.46e-03 1.45e-42
Interactor Also a MoonDB EMF protein
TFP11_HUMAN No
GASP2_HUMAN No
KIFC3_HUMAN No
CARD9_HUMAN No
ABI2_HUMAN Yes: Q9NYB9 (MoonDB)
AP1M1_HUMAN No
ZNF76_HUMAN No
MNS1_HUMAN No
DDX6_HUMAN No
CCD13_HUMAN No
TEANC_HUMAN No
GMCLL_HUMAN No
GEM_HUMAN No
C102B_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
P55G_HUMAN Yes: Q92569 (MoonDB)
CC136_HUMAN No
NDK7_HUMAN No
C2CD6_HUMAN No
CEP57_HUMAN No
IFT20_HUMAN No
CE57L_HUMAN No
CCHCR_HUMAN No
A26L1_HUMAN No
CA109_HUMAN No
PKN1_HUMAN No
RPC3_HUMAN No
EXOC7_HUMAN No
ZN124_HUMAN No
TTC23_HUMAN No
KANL1_HUMAN No
SMCE1_HUMAN No
LENG1_HUMAN No
SPC1L_HUMAN No
TRAF4_HUMAN No
UBP2_HUMAN Yes: O75604 (MoonDB)
GPAN1_HUMAN No
ATF4_HUMAN No
GBG13_HUMAN No
CEP63_HUMAN No
CDC23_HUMAN No
ARI2_HUMAN No
PPP5_HUMAN No
1433E_HUMAN Yes: P62258 (MoonDB)
TSG10_HUMAN No
PHF1_HUMAN No
UBS3A_HUMAN No
CDC37_HUMAN Yes: Q16543 (MoonDB)
GA2L2_HUMAN No
SMRD1_HUMAN No
SYQ_HUMAN No
SMYD1_HUMAN No
EXOC1_HUMAN No
BAG2_HUMAN No
GBB1_HUMAN No
DNJC7_HUMAN No
STX11_HUMAN No
KIF9_HUMAN No
CTNA3_HUMAN No
GAS8_HUMAN No
Q6P9E2_HUMAN No
CDKL3_HUMAN No
CF206_HUMAN No
PSPC1_HUMAN No
TCAF1_HUMAN No
CCD24_HUMAN No
ACTN2_HUMAN No
BORC6_HUMAN No
TRI68_HUMAN No
HNRPC_HUMAN No
CE170_HUMAN No
MCAF1_HUMAN No
GBRL1_HUMAN No
DCTN1_HUMAN No
PIBF1_HUMAN No
CCD57_HUMAN No
MATR3_HUMAN No
DYST_HUMAN No
CE126_HUMAN No
KIF3A_HUMAN No
AL2SB_HUMAN No
ANKH1_HUMAN No
TBB2A_HUMAN No
NECA1_HUMAN No
MAP1A_HUMAN No
UBS3B_HUMAN No
IF4A3_HUMAN No
AMOT_HUMAN No
1433Z_HUMAN Yes: P63104 (MoonDB)
KALRN_HUMAN No
RIMB1_HUMAN No
RANB9_HUMAN No
MIC60_HUMAN No
FEZ1_HUMAN No
DPYL2_HUMAN No
1433T_HUMAN No
CTRO_HUMAN No
AKAP9_HUMAN No
ZN197_HUMAN No
NDEL1_HUMAN Yes: Q9GZM8 (MoonDB)
1433G_HUMAN No
3BP5_HUMAN No
ACTG_HUMAN No
AEDO_HUMAN No
AF10_HUMAN No
AIMP2_HUMAN No
AKAP6_HUMAN No
ARMC7_HUMAN No
ATF5_HUMAN No
BFSP2_HUMAN No
BICD1_HUMAN No
BRD1_HUMAN No
BRE1B_HUMAN No
CBPC1_HUMAN No
CC141_HUMAN No
CC197_HUMAN No
CCD92_HUMAN No
CDC5L_HUMAN No
CH033_HUMAN No
CK5P3_HUMAN No
CLUS_HUMAN No
CN166_HUMAN No
CO4A1_HUMAN No
CO6A2_HUMAN No
CRNL1_HUMAN No
DCTN2_HUMAN No
DMD_HUMAN No
DPYL3_HUMAN No
DYHC1_HUMAN No
EF2_HUMAN No
EIF3H_HUMAN No
EMSY_HUMAN No
EXOC4_HUMAN No
FBX34_HUMAN No
FBX41_HUMAN No
FRYL_HUMAN No
GCC1_HUMAN No
GNPTA_HUMAN No
GRAP1_HUMAN No
GRDN_HUMAN No
HERC2_HUMAN No
IFT74_HUMAN No
ITSN1_HUMAN No
KCNQ5_HUMAN No
KIF3C_HUMAN No
KIFA3_HUMAN No
LIPA3_HUMAN No
LIS1_HUMAN No
MACF1_HUMAN No
MEMO1_HUMAN No
MIPT3_HUMAN No
MO4L2_HUMAN No
MPPD1_HUMAN No
MVP_HUMAN No
MYH7_HUMAN No
MYT1L_HUMAN No
NDE1_HUMAN No
NFM_HUMAN No
NOE1_HUMAN No
NU160_HUMAN No
PCNT_HUMAN No
PCX4_HUMAN No
PDE4B_HUMAN No
PGK1_HUMAN Yes: P00558 (MoonDB)
PP4R1_HUMAN No
PPM1E_HUMAN No
Q59EY7_HUMAN No
RAD21_HUMAN No
RASF7_HUMAN No
RBGP1_HUMAN No
RBM41_HUMAN No
RBNS5_HUMAN No
ROGDI_HUMAN No
SMC2_HUMAN No
SMC3_HUMAN Yes: Q9UQE7 (MoonDB)
SMC5_HUMAN No
SNX6_HUMAN No
SPRL1_HUMAN No
SPTB2_HUMAN No
SPTN1_HUMAN No
SPTN4_HUMAN No
SRGP2_HUMAN No
SRGP3_HUMAN No
STX18_HUMAN No
SUFU_HUMAN No
SYBU_HUMAN No
SYNE1_HUMAN No
SYNEM_HUMAN No
TALAN_HUMAN No
TBB5_HUMAN No
TIAM2_HUMAN No
TNIK_HUMAN No
TNKS1_HUMAN No
TNKS2_HUMAN No
TRI29_HUMAN No
TRIO_HUMAN No
TSR2_HUMAN No
UTRO_HUMAN No
XPP1_HUMAN No
XRN2_HUMAN No
ZN365_HUMAN No
PMID Article Title
9455484 Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.
10814723 Disruption of two novel genes by a translocation co-segregating with schizophrenia.
11468279 Chromosome 1 loci in Finnish schizophrenia families.
12506198 Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.
12573262 Evolutionary constraints on the Disrupted in Schizophrenia locus.
12812986 DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
14532331 Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.
14962739 Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
15386212 Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.
15797709 Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.
15939883 Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.
16510495 Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.
16710414 The DNA sequence and biological annotation of human chromosome 1.
17035248 DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.
17389905 A novel DISC1-interacting partner DISC1-binding zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth.
18955030 DISC1-kendrin interaction is involved in centrosomal microtubule network formation.
19303846 Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.
19502360 Disc1 regulates granule cell migration in the developing hippocampus.
19805229 DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms.
22228767 CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
OMIM ID Disease Name
604906 Schizophrenia 9
Domain Name Domain ID Source
DISC1 IPR026081 InterPro
PTHR14332 PTHR14332 PANTHER
T00071 T00071 PIR