Protein: Q9NRI5 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9NRI5 (Uniprot)	DISC1_HUMAN	DISC1	Disrupted in schizophrenia 1 protein	human	No

Protein Function

Uniprot: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	1	GO:0006725	cellular aromatic compound metabolic process	222	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1	GO:0035556	intracellular signal transduction
1	GO:0032268	regulation of cellular protein metabolic process
1	GO:0043067	regulation of programmed cell death
1	GO:0009966	regulation of signal transduction
37	GO:0007165	signal transduction
116	GO:0019538	protein metabolic process
116	GO:0060255	regulation of macromolecule metabolic process
222	GO:0006139	nucleobase-containing compound metabolic process
222	GO:0060255	regulation of macromolecule metabolic process
222	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1	GO:0005829	cytosol
1	GO:0005634	nucleus
37	GO:0005829	cytosol
50	GO:0005829	cytosol
50	GO:0005634	nucleus
84	GO:0005634	nucleus
92	GO:0005634	nucleus
116	GO:0005829	cytosol
116	GO:0070013	intracellular organelle lumen
116	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000226	microtubule cytoskeleton organization	IMP
GO:0001764	neuron migration	IMP
GO:0001954	positive regulation of cell-matrix adhesion	IEA
GO:0002052	positive regulation of neuroblast proliferation	IGI
GO:0021846	cell proliferation in forebrain	IEA
GO:0021852	pyramidal neuron migration	IEA
GO:0030177	positive regulation of Wnt signaling pathway	IGI
GO:0031929	TOR signaling	IEA
GO:0032091	negative regulation of protein binding	ISS
GO:0045773	positive regulation of axon extension	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IEA
GO:0005739	mitochondrion	IDA
GO:0005783	endoplasmic reticulum	IEA
GO:0005813	centrosome	IDA
GO:0005829	cytosol	IEA
GO:0005871	kinesin complex	IEA
GO:0005874	microtubule	IEA
GO:0008021	synaptic vesicle	IEA
GO:0014069	postsynaptic density	IEA
GO:0030054	cell junction	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	8.26e-33	3.22e-89
GO:0005634	nucleus	GO:0008021	synaptic vesicle	1.32e-02	8.03e-21
GO:0005634	nucleus	GO:0045211	postsynaptic membrane	4.18e-05	1.09e-18
GO:0005783	endoplasmic reticulum	GO:0005813	centrosome	5.46e-03	1.45e-42

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433E_HUMAN	Yes: P62258 (MoonDB)
1433G_HUMAN	No
1433T_HUMAN	No
1433Z_HUMAN	Yes: P63104 (MoonDB)
3BP5_HUMAN	No
A26L1_HUMAN	No
ABI2_HUMAN	Yes: Q9NYB9 (MoonDB)
ACTG_HUMAN	No
ACTN2_HUMAN	No
AEDO_HUMAN	No

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Publications Associated

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PMID	Article Title
9455484	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.
10814723	Disruption of two novel genes by a translocation co-segregating with schizophrenia.
11468279	Chromosome 1 loci in Finnish schizophrenia families.
12506198	Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.
12573262	Evolutionary constraints on the Disrupted in Schizophrenia locus.
12812986	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
14532331	Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.
14962739	Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
15386212	Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.
15797709	Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.

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OMIM Diseases Associated

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OMIM ID	Disease Name
604906	Schizophrenia 9

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Protein Domains Associated

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Domain Name	Domain ID	Source
DISC1	IPR026081	InterPro
PTHR14332	PTHR14332	PANTHER
T00071	T00071	PIR

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