Protein: Q9NYB9 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9NYB9 (Uniprot)	ABI2_HUMAN	ABI2	Abl interactor 2	human	No

Protein Function

Uniprot: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-medi more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	254, 664	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	353	1.88e-02	4.66e-37
GO:0019538	protein metabolic process	254, 664	GO:0016070	RNA metabolic process	715	5.15e-08	2.82e-13

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
93	GO:0034645	cellular macromolecule biosynthetic process
93	GO:0034654	nucleobase-containing compound biosynthetic process
93	GO:0019538	protein metabolic process
93	GO:0051252	regulation of RNA metabolic process
93	GO:0010468	regulation of gene expression
121	GO:0010467	gene expression
121	GO:0060255	regulation of macromolecule metabolic process
121	GO:0007165	signal transduction
254	GO:0044267	cellular protein metabolic process
254	GO:0048584	positive regulation of response to stimulus

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
84	GO:0005634	nucleus
93	GO:0005829	cytosol
93	GO:0005634	nucleus
121	GO:0005634	nucleus
140	GO:0043232	intracellular non-membrane-bounded organelle
179	GO:0012505	endomembrane system
185	GO:0005829	cytosol
254	GO:0005829	cytosol
254	GO:0005634	nucleus
298	GO:0015630	microtubule cytoskeleton

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006928	movement of cell or subcellular component	IDA
GO:0007010	cytoskeleton organization	TAS
GO:0008154	actin polymerization or depolymerization	NAS
GO:0016032	viral process	IEA
GO:0016477	cell migration	TAS
GO:0016601	Rac protein signal transduction	IDA
GO:0018108	peptidyl-tyrosine phosphorylation	IDA
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	IDA

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	TAS
GO:0005829	cytosol	IDA
GO:0005856	cytoskeleton	IEA
GO:0030027	lamellipodium	IDA
GO:0030175	filopodium	IDA
GO:0031209	SCAR complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 162 entries

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Interactor	Also a MoonDB EMF protein
3BP1_HUMAN	No
A0A024R8L2_HUMAN	No
AAPK1_HUMAN	No
AAPK2_HUMAN	No
ABI1_HUMAN	No
ABI3_HUMAN	No
ABL2_HUMAN	Yes: P42684 (MoonDB)
ABLM3_HUMAN	No
ADA19_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)

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Publications Associated

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PMID	Article Title
7590236	Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.
8649853	Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.
10498863	Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity.
11516653	The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18669648	A quantitative atlas of mitotic phosphorylation.
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21107423	Structure and control of the actin regulatory WAVE complex.
21269460	Initial characterization of the human central proteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
ABI	IPR028457	InterPro
ABI2	IPR036993	InterPro
Abi2_SH3	IPR035726	InterPro
Abi_HHR	PF07815	Pfam
Abl-interactor_HHR_dom	IPR012849	InterPro
G01936	G01936	PIR
PTHR10460	PTHR10460	PANTHER
PTHR10460:SF0	PTHR10460:SF0	PANTHER
SH3	PS50002	PROSITE
SH3	SM00326	SMART

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