Protein: P50552

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P50552 (Uniprot) VASP_HUMAN VASP Vasodilator-stimulated phosphoprotein human No
Uniprot: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 164, 248 GO:0016070 RNA metabolic process 715 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
164 GO:0044267 cellular protein metabolic process
164 GO:0060255 regulation of macromolecule metabolic process
164 GO:0007165 signal transduction
248 GO:0044267 cellular protein metabolic process
248 GO:0045893 positive regulation of transcription, DNA-templated
248 GO:0051246 regulation of protein metabolic process
248 GO:0007165 signal transduction
419 GO:0022607 cellular component assembly
715 GO:0006396 RNA processing
715 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
248 GO:0031981 nuclear lumen
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
715 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001843 neural tube closure IEA
GO:0007411 axon guidance TAS
GO:0008154 actin polymerization or depolymerization IEA
GO:0030838 positive regulation of actin filament polymerization IDA
GO:0034329 cell junction assembly TAS
GO:0051289 protein homotetramerization IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IDA
GO:0005923 bicellular tight junction IEA
GO:0005925 focal adhesion IDA
GO:0015629 actin cytoskeleton TAS
GO:0031258 lamellipodium membrane IEA
GO:0031527 filopodium membrane IEA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7737110 The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.
7828592 Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP.
7925440 Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition.
8182057 cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.
8812448 Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization.
10087267 Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes.
10438535 The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation.
10637295 LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.
10801818 Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.
10990454 Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity.
12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14706852 Vasodilator-stimulated phosphoprotein is a substrate for protein kinase C.
15469845 Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15569942 The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat.
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15939738 Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.
16197368 Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser 157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets.
16631741 Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.
17082196 AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein.
17914456 Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.
18088087 Phosphoproteome of resting human platelets.
18559661 Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.
18669648 A quantitative atlas of mitotic phosphorylation.
18689676 Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding.
19109554 Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
WH1/EVH1_dom IPR000697 InterPro
PH-like_dom_sf IPR011993 InterPro
VASP_tetra IPR014885 InterPro
VASP/EVL IPR017354 InterPro
VASP IPR034367 InterPro
WH1 PF00568 Pfam
VASP_tetra PF08776 Pfam
Vasodilator_Phospo PIRSF038010 PIRSF
WH1 PS50229 PROSITE
PTHR11202:SF12 PTHR11202:SF12 PANTHER
S51797 S51797 PIR
WH1 SM00461 SMART
SSF50729 SSF50729 SUPFAM