Protein: P22736 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P22736 (Uniprot)	NR4A1_HUMAN	NR4A1	Nuclear receptor subfamily 4 group A member 1	human	No

Protein Function

Uniprot: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	152	GO:0007165	signal transduction	169	5.44e-126	5.27e-27
GO:0007165	signal transduction	169	GO:0034641	cellular nitrogen compound metabolic process	180	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
42	GO:0031325	positive regulation of cellular metabolic process
42	GO:0010604	positive regulation of macromolecule metabolic process
42	GO:0051173	positive regulation of nitrogen compound metabolic process
42	GO:0006355	regulation of transcription, DNA-templated
42	GO:0007165	signal transduction
45	GO:0071495	cellular response to endogenous stimulus
45	GO:0071310	cellular response to organic substance
45	GO:0032270	positive regulation of cellular protein metabolic process
45	GO:0006468	protein phosphorylation
45	GO:0042325	regulation of phosphorylation

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
42	GO:0005829	cytosol
42	GO:0005654	nucleoplasm
45	GO:0005829	cytosol
45	GO:0031981	nuclear lumen
45	GO:0005886	plasma membrane
49	GO:0043232	intracellular non-membrane-bounded organelle
49	GO:0005654	nucleoplasm
152	GO:0005829	cytosol
152	GO:0005634	nucleus
169	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001938	positive regulation of endothelial cell proliferation	IMP
GO:0002042	cell migration involved in sprouting angiogenesis	IDA
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS
GO:0007165	signal transduction	TAS
GO:0030522	intracellular receptor signaling pathway	IEA
GO:0035767	endothelial cell chemotaxis	IMP
GO:0035924	cellular response to vascular endothelial growth factor stimulus	IMP
GO:0043401	steroid hormone mediated signaling pathway	IEA
GO:0043491	protein kinase B signaling	TAS
GO:0044344	cellular response to fibroblast growth factor stimulus	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	IDA
GO:0031965	nuclear membrane	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABCA5_HUMAN	No
ABCBB_HUMAN	No
ABCG8_HUMAN	No
AKIB1_HUMAN	No
ARGAL_HUMAN	No
ARHG5_HUMAN	No
ATM_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)
BBS10_HUMAN	No
BCL2_HUMAN	No

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Publications Associated

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PMID	Article Title
1651101	Phorbol ester, forskolin, and serum induction of a human colon nuclear hormone receptor gene related to the NUR 77/NGFI-B genes.
2283997	A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily.
2626032	Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15459248	CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation.
15466594	Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16541075	The finished DNA sequence of human chromosome 12.
17360704	RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.
18669648	A quantitative atlas of mitotic phosphorylation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
A37251	A37251	PIR
HMRNUCRECPTR	PR01285	PRINTS
HOLI	SM00430	SMART
Hormone_recep	PF00104	Pfam
NHR_like_dom_sf	IPR035500	InterPro
NR_LBD	PS51843	PROSITE
Nuc_orp_HMR_rcpt	IPR003071	InterPro
Nuc_orph_rcpt	IPR003070	InterPro
Nucl_hrmn_rcpt_lig-bd	IPR000536	InterPro
Nuclear_hrmn_rcpt	IPR001723	InterPro

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