Protein: Q12873

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q12873 (Uniprot) CHD3_HUMAN CHD3 Chromodomain-helicase-DNA-binding protein 3 human No
Uniprot: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 27 GO:0007165 signal transduction 609 1.10e-111 5.07e-25
GO:0006725 cellular aromatic compound metabolic process 484 GO:0007165 signal transduction 609 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
51 GO:0060255 regulation of macromolecule metabolic process
81 GO:0006139 nucleobase-containing compound metabolic process
99 GO:0031325 positive regulation of cellular metabolic process
99 GO:0010628 positive regulation of gene expression
99 GO:0051173 positive regulation of nitrogen compound metabolic process
99 GO:0019538 protein metabolic process
99 GO:0006357 regulation of transcription from RNA polymerase II promoter
99 GO:0007165 signal transduction
191 GO:0006355 regulation of transcription, DNA-templated
207 GO:0007165 signal transduction
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
383 GO:0044267 cellular protein metabolic process
383 GO:0006355 regulation of transcription, DNA-templated
413 GO:0044267 cellular protein metabolic process
413 GO:0031326 regulation of cellular biosynthetic process
413 GO:0010468 regulation of gene expression
413 GO:0010556 regulation of macromolecule biosynthetic process
413 GO:0007165 signal transduction
413 GO:0006351 transcription, DNA-templated
427 GO:0044267 cellular protein metabolic process
427 GO:0010467 gene expression
427 GO:0060255 regulation of macromolecule metabolic process
430 GO:0019538 protein metabolic process
431 GO:0019538 protein metabolic process
431 GO:0060255 regulation of macromolecule metabolic process
484 GO:0006139 nucleobase-containing compound metabolic process
484 GO:1901362 organic cyclic compound biosynthetic process
484 GO:0019538 protein metabolic process
484 GO:0060255 regulation of macromolecule metabolic process
484 GO:0007165 signal transduction
609 GO:0007166 cell surface receptor signaling pathway
609 GO:0006464 cellular protein modification process
609 GO:0071310 cellular response to organic substance
609 GO:0031325 positive regulation of cellular metabolic process
609 GO:0010604 positive regulation of macromolecule metabolic process
609 GO:0051173 positive regulation of nitrogen compound metabolic process
609 GO:0051246 regulation of protein metabolic process
609 GO:0006355 regulation of transcription, DNA-templated
645 GO:0060255 regulation of macromolecule metabolic process
658 GO:0019538 protein metabolic process
742 GO:0031325 positive regulation of cellular metabolic process
742 GO:0010604 positive regulation of macromolecule metabolic process
742 GO:0051173 positive regulation of nitrogen compound metabolic process
742 GO:0006357 regulation of transcription from RNA polymerase II promoter
780 GO:0006355 regulation of transcription, DNA-templated
816 GO:0016070 RNA metabolic process
816 GO:0010467 gene expression
816 GO:0034654 nucleobase-containing compound biosynthetic process
816 GO:0010646 regulation of cell communication
816 GO:2000112 regulation of cellular macromolecule biosynthetic process
816 GO:0019219 regulation of nucleobase-containing compound metabolic process
816 GO:0023051 regulation of signaling
816 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
27 GO:0031981 nuclear lumen
51 GO:0005634 nucleus
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
99 GO:0005654 nucleoplasm
191 GO:0031981 nuclear lumen
207 GO:0005829 cytosol
207 GO:0005654 nucleoplasm
376 GO:0005829 cytosol
376 GO:0005634 nucleus
383 GO:0070013 intracellular organelle lumen
383 GO:0044428 nuclear part
413 GO:0005654 nucleoplasm
427 GO:0070013 intracellular organelle lumen
431 GO:0005829 cytosol
484 GO:0070013 intracellular organelle lumen
484 GO:0005634 nucleus
609 GO:0005829 cytosol
609 GO:0043232 intracellular non-membrane-bounded organelle
609 GO:0070013 intracellular organelle lumen
609 GO:0005634 nucleus
609 GO:0005886 plasma membrane
645 GO:0005829 cytosol
645 GO:0005634 nucleus
658 GO:0005634 nucleus
742 GO:0005654 nucleoplasm
780 GO:0005654 nucleoplasm
816 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006333 chromatin assembly or disassembly IEA
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated NAS
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS
GO:0007051 spindle organization IDA
GO:0007098 centrosome cycle IDA
GO:0016575 histone deacetylation IEA
GO:0032508 DNA duplex unwinding IEA
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus NAS
GO:0005654 nucleoplasm TAS
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005813 centrosome IDA
GO:0005815 microtubule organizing center IDA
GO:0016581 NuRD complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
NFL_HUMAN No
PLK4_HUMAN No
CRCT1_HUMAN No
BARD1_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
IKZF1_HUMAN No
GPS2_HUMAN No
HD_HUMAN Yes: P42858 (MoonDB)
FUBP1_HUMAN No
CSTF2_HUMAN No
LC7L2_HUMAN No
CTBP1_HUMAN No
SRC8_HUMAN Yes: Q14247 (MoonDB)
P53_HUMAN Yes: P04637 (MoonDB)
SIR6_HUMAN No
UBC9_HUMAN Yes: P63279 (MoonDB)
CREB1_HUMAN No
VIME_HUMAN Yes: P08670 (MoonDB)
SGSM2_HUMAN No
DCUP_HUMAN No
PUR6_HUMAN No
SUMO1_HUMAN Yes: P63165 (MoonDB)
SAT1_HUMAN No
PTN_HUMAN No
SUMO2_HUMAN No
ZHX1_HUMAN No
SKIL_HUMAN No
RED_HUMAN No
ACTY_HUMAN No
ADHX_HUMAN No
ADT3_HUMAN No
AIMP2_HUMAN No
ATIF1_HUMAN No
CASP6_HUMAN No
CASP8_HUMAN No
CBPE_HUMAN No
CD017_HUMAN No
CHM4B_HUMAN No
F16P2_HUMAN No
FABP4_HUMAN No
GA45A_HUMAN No
GIT1_HUMAN No
GSK3B_HUMAN No
HABP4_HUMAN No
HCD2_HUMAN No
HS105_HUMAN No
IMB1_HUMAN No
KIF15_HUMAN No
LRIF1_HUMAN No
MA2A2_HUMAN No
MAFG_HUMAN No
MIC60_HUMAN No
MX1_HUMAN No
NR1H2_HUMAN Yes: P55055 (MoonDB)
NR4A1_HUMAN Yes: P22736 (MoonDB)
NS1BP_HUMAN No
P73_HUMAN No
PAIRB_HUMAN No
PCNT_HUMAN No
PIAS4_HUMAN No
PIMT_HUMAN No
PR40A_HUMAN Yes: O75400 (MoonDB)
PRG2_HUMAN No
PSME1_HUMAN No
PTPRS_HUMAN No
PUF60_HUMAN No
Q5VU21_HUMAN No
Q9H0E4_HUMAN No
RAD51_HUMAN No
RETR2_HUMAN No
RGS2_HUMAN No
RL29_HUMAN No
S27A6_HUMAN No
SAFB1_HUMAN No
SDCG3_HUMAN No
SERF2_HUMAN No
SP1_HUMAN No
SRRT_HUMAN No
T22D1_HUMAN No
TAL1_HUMAN No
TALDO_HUMAN No
TCRG1_HUMAN No
THOC7_HUMAN No
TIF1B_HUMAN No
TNNT1_HUMAN No
TNR14_HUMAN No
TSN6_HUMAN No
TTHY_HUMAN No
TXND9_HUMAN No
UBA3_HUMAN Yes: Q8TBC4 (MoonDB)
XRCC4_HUMAN No
YAED1_HUMAN No
PMID Article Title
7560064 Molecular analysis of a major antigenic region of the 240 kD protein of Mi-2 autoantigen.
9326634 Characterization of the CHD family of proteins.
9688266 Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family.
9804427 Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
11230151 Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
12505151 Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17626165 Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
SNF2_N IPR000330 InterPro
Chromo/chromo_shadow_dom IPR000953 InterPro
Helicase_C IPR001650 InterPro
Znf_PHD IPR001965 InterPro
DNA/RNA_helicase_DEAH_CS IPR002464 InterPro
DUF1086 IPR009462 InterPro
DUF1087 IPR009463 InterPro
Znf_FYVE_PHD IPR011011 InterPro
CHD_C2 IPR012957 InterPro
CHD_N IPR012958 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
Helicase_ATP-bd IPR014001 InterPro
Chromo-like_dom_sf IPR016197 InterPro
Zinc_finger_PHD-type_CS IPR019786 InterPro
Znf_PHD-finger IPR019787 InterPro
Chromodomain_CS IPR023779 InterPro
Chromo_domain IPR023780 InterPro
P-loop_NTPase IPR027417 InterPro
CHD3 IPR028722 InterPro
HMG_box_dom_sf IPR036910 InterPro
SNF2_N PF00176 Pfam
Helicase_C PF00271 Pfam
Chromo PF00385 Pfam
PHD PF00628 Pfam
DUF1086 PF06461 Pfam
DUF1087 PF06465 Pfam
CHDNT PF08073 Pfam
CHDCT2 PF08074 Pfam
CHROMO_1 PS00598 PROSITE
DEAH_ATP_HELICASE PS00690 PROSITE
ZF_PHD_1 PS01359 PROSITE
CHROMO_2 PS50013 PROSITE
ZF_PHD_2 PS50016 PROSITE
HELICASE_ATP_BIND_1 PS51192 PROSITE
HELICASE_CTER PS51194 PROSITE
PTHR10799:SF544 PTHR10799:SF544 PANTHER
PHD SM00249 SMART
CHROMO SM00298 SMART
DEXDc SM00487 SMART
HELICc SM00490 SMART
DUF1086 SM01146 SMART
DUF1087 SM01147 SMART
SSF47095 SSF47095 SUPFAM
SSF52540 SSF52540 SUPFAM
SSF54160 SSF54160 SUPFAM
SSF57903 SSF57903 SUPFAM
CHROMO cd00024 CDD
HELICc cd00079 CDD