Protein: P63165 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P63165 (Uniprot)	SUMO1_HUMAN	SUMO1	Small ubiquitin-related modifier 1	human	No

Protein Function

Uniprot: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANB more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0034641	cellular nitrogen compound metabolic process	504, 810	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
17	GO:0006355	regulation of transcription, DNA-templated
99	GO:0031325	positive regulation of cellular metabolic process
99	GO:0010628	positive regulation of gene expression
99	GO:0051173	positive regulation of nitrogen compound metabolic process
99	GO:0019538	protein metabolic process
99	GO:0006357	regulation of transcription from RNA polymerase II promoter
99	GO:0007165	signal transduction
155	GO:0006464	cellular protein modification process
155	GO:0060255	regulation of macromolecule metabolic process
169	GO:0030522	intracellular receptor signaling pathway

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
17	GO:0005829	cytosol
17	GO:0005654	nucleoplasm
65	GO:0012505	endomembrane system
65	GO:0016021	integral component of membrane
99	GO:0005654	nucleoplasm
155	GO:0005634	nucleus
169	GO:0005654	nucleoplasm
191	GO:0031981	nuclear lumen
192	GO:0005829	cytosol
192	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS
GO:0006281	DNA repair	TAS
GO:0006303	double-strand break repair via nonhomologous end joining	TAS
GO:0016032	viral process	IEA
GO:0016925	protein sumoylation	TAS
GO:0030578	PML body organization	IEA
GO:0031334	positive regulation of protein complex assembly	IDA
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA
GO:0032880	regulation of protein localization	TAS
GO:0034605	cellular response to heat	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000792	heterochromatin	IEA
GO:0001650	fibrillar center	IEA
GO:0001741	XY body	IEA
GO:0005634	nucleus	IDA
GO:0005643	nuclear pore	TAS
GO:0005654	nucleoplasm	TAS
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IEA
GO:0005886	plasma membrane	IDA
GO:0008076	voltage-gated potassium channel complex	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000792	heterochromatin	GO:0005886	plasma membrane	5.86e-03	1.10e-44
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0008076	voltage-gated potassium channel complex	5.52e-06	7.82e-07
GO:0005634	nucleus	GO:0045202	synapse	1.10e-08	8.94e-15
GO:0005643	nuclear pore	GO:0005886	plasma membrane	1.14e-02	8.77e-07
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005654	nucleoplasm	GO:0008076	voltage-gated potassium channel complex	8.67e-04	1.18e-05
GO:0005654	nucleoplasm	GO:0045202	synapse	3.30e-10	4.22e-25
GO:0005730	nucleolus	GO:0005886	plasma membrane	7.70e-47	3.09e-07
GO:0005886	plasma membrane	GO:0016604	nuclear body	1.42e-38	3.32e-172

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ARIP4_HUMAN	No
ATF2_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)
ATX3_HUMAN	No
BIRC3_HUMAN	No
BLM_HUMAN	No
BRCA1_HUMAN	No
BTBD3_HUMAN	No
CARD9_HUMAN	No
CASP2_HUMAN	No

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Publications Associated

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PMID	Article Title
8806687	PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
8812453	UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins.
8906799	Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.
8978815	A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.
9019411	A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
9119407	SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.
9162015	Preferential modification of nuclear proteins by a novel ubiquitin-like molecule.
9654451	Structure determination of the small ubiquitin-related modifier SUMO-1.
10574707	Cell cycle regulation of PML modification and ND10 composition.
10961991	Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.

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OMIM Diseases Associated

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OMIM ID	Disease Name
613705	Non-syndromic orofacial cleft 10

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Protein Domains Associated

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Domain Name	Domain ID	Source
Rad60-SLD	PF11976	Pfam
Rad60/SUMO-like_dom	IPR022617	InterPro
SSF54236	SSF54236	SUPFAM
Sumo	IPR033950	InterPro
Sumo	cd01763	CDD
Ubiquitin-like_domsf	IPR029071	InterPro
UBIQUITIN_2	PS50053	PROSITE
Ubiquitin_dom	IPR000626	InterPro
UBQ	SM00213	SMART

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