| 1303181 |
A novel mutation in the p53 gene in a Burkitt's lymphoma cell line. |
| 1327751 |
Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. |
| 1394225 |
Frequent p53 mutations in head and neck cancer. |
| 1437144 |
p53 mutations in Raji cells: characterization and localization relative to other Burkitt's lymphomas. |
| 1459726 |
The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma. |
| 1565144 |
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. |
| 1631151 |
An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma. |
| 1647768 |
Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors. |
| 1672732 |
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. |
| 1694291 |
Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. |
| 1699228 |
p53 mutations in colorectal cancer. |
| 1705009 |
The tumor suppressor p53 is bound to RNA by a stable covalent linkage. |
| 1737852 |
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia. |
| 1848668 |
Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. |
| 1849234 |
Mutational hotspot in the p53 gene in human hepatocellular carcinomas. |
| 1868473 |
p53 gene mutations in Barrett's epithelium and esophageal cancer. |
| 1905840 |
p53 mutations in human cancers. |
| 1915267 |
p53 is frequently mutated in Burkitt's lymphoma cell lines. |
| 1933902 |
A germ line mutation in exon 5 of the p53 gene in an extended cancer family. |
| 1978757 |
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. |
| 1999338 |
Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population. |
| 2141171 |
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. |
| 2156209 |
The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif. |
| 2259385 |
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. |
| 2263646 |
Frequent mutation of the p53 gene in human esophageal cancer. |
| 2905688 |
A variation in the structure of the protein-coding region of the human p53 gene. |
| 2946935 |
Characterization of the human p53 gene. |
| 3025664 |
Molecular basis for heterogeneity of the human p53 protein. |
| 3894933 |
Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. |
| 4006916 |
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. |
| 6396087 |
Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene. |
| 7682763 |
p53 alterations in human squamous cell carcinomas and carcinoma cell lines. |
| 7773777 |
Solution structure of the tetrameric minimum transforming domain of p53. |
| 7878469 |
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. |
| 7887414 |
Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome. |
| 8013454 |
A temperature-sensitive mutant of human p53. |
| 8023157 |
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. |
| 8023159 |
High-resolution structure of the oligomerization domain of p53 by multidimensional NMR. |
| 8118819 |
Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. |
| 8266092 |
p53: at the crossroads of molecular carcinogenesis and risk assessment. |
| 8316628 |
Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs. |
| 8336944 |
Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors. |
| 8402617 |
The incidence of p53 mutations increases with progression of head and neck cancer. |
| 8632903 |
The human tumour suppressor gene p53 is alternatively spliced in normal cells. |
| 8632915 |
Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus. |
| 8718514 |
Germline mutations in the TP53 gene. |
| 8825920 |
An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53. |
| 8829627 |
Molecular analysis of the TP53 gene in Barrett's adenocarcinoma. |
| 8829653 |
Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epidemiological analyses. |
| 8875926 |
Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. |
| 8875929 |
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. |
| 9101296 |
Single-step DGGE-based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer. |
| 9321402 |
Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain. |
| 9372954 |
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. |
| 9419979 |
Drastic genetic instability of tumors and normal tissues in Turcot syndrome. |
| 9450901 |
Detection of p53 gene mutations in oral squamous cell carcinomas of a black African population sample. |
| 9452042 |
A germline missense mutation R337C in exon 10 of the human p53 gene. |
| 9840937 |
Regulation of CAK kinase activity by p53. |
| 10484981 |
Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family. |
| 10549356 |
p53 and human cancer: the first ten thousand mutations. |
| 10551826 |
A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain. |
| 10570149 |
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. |
| 10606744 |
Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. |
| 10644996 |
p53 is involved in the p120E4F-mediated growth arrest. |
| 10656795 |
Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry. |
| 10722742 |
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. |
| 10884347 |
The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A. |
| 10951572 |
The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. |
| 11007800 |
p53 amino acids 339-346 represent the minimal p53 repression domain. |
| 11023613 |
Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8. |
| 11025664 |
The function of PML in p53-dependent apoptosis. |
| 11058590 |
Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. |
| 11124955 |
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. |
| 11239457 |
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. |
| 11447225 |
Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. |
| 11481490 |
An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. |
| 11546806 |
Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. |
| 11551930 |
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. |
| 11554448 |
Zinc binding and redox control of p53 structure and function. |
| 11554766 |
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. |
| 11672523 |
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. |
| 11706030 |
Differential effect of ik3-1/cables on p53- and p73-induced cell death. |
| 11740489 |
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. |
| 11780126 |
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. |
| 11925430 |
Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. |
| 12085209 |
Investigations on a clinically and functionally unusual and novel germline p53 mutation. |
| 12507430 |
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. |
| 12702766 |
Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). |
| 12724314 |
Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305. |
| 12750254 |
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. |
| 12810724 |
The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. |
| 12851404 |
TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. |
| 12944468 |
Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination. |
| 14534297 |
Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. |
| 14660794 |
Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin. |
| 14702039 |
Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 14702041 |
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. |
| 15053879 |
Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. |
| 15053880 |
A dynamic role of HAUSP in the p53-Mdm2 pathway. |
| 15109303 |
Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control. |
| 15136035 |
The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. |
| 15186775 |
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. |
| 15340061 |
Regulation of human p53 activity and cell localization by alternative splicing. |
| 15489334 |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15525938 |
Regulation of p53 activity through lysine methylation. |
| 15701641 |
Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif. |
| 15855171 |
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. |
| 15866171 |
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. |
| 16131611 |
p53 isoforms can regulate p53 transcriptional activity. |
| 16219768 |
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. |
| 16322561 |
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. |
| 16376338 |
Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. |
| 16377624 |
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. |
| 16402859 |
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. |
| 16415881 |
Structural basis for the methylation site specificity of SET7/9. |
| 16474402 |
Molecular recognition of p53 and MDM2 by USP7/HAUSP. |
| 16625196 |
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |
| 16704422 |
The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines. |
| 16793544 |
Structural basis of DNA recognition by p53 tetramers. |
| 16845383 |
Critical role for Daxx in regulating Mdm2. |
| 16959974 |
The consensus coding sequences of human breast and colorectal cancers. |
| 17015838 |
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. |
| 17108107 |
LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. |
| 17108971 |
Repression of p53 activity by Smyd2-mediated methylation. |
| 17121812 |
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation. |
| 17145718 |
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. |
| 17170702 |
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. |
| 17224074 |
Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas. |
| 17245430 |
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. |
| 17254968 |
PRAK is essential for ras-induced senescence and tumor suppression. |
| 17311302 |
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. |
| 17317671 |
The notch regulator MAML1 interacts with p53 and functions as a coactivator. |
| 17332504 |
Dynamic regulation of p53 subnuclear localization and senescence by MORC3. |
| 17349958 |
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. |
| 17467953 |
Nine-amino-acid transactivation domain: establishment and prediction utilities. |
| 17525332 |
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. |
| 17591690 |
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. |
| 17707234 |
Modulation of p53 function by SET8-mediated methylation at lysine 382. |
| 17719541 |
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. |
| 17805299 |
p53 is regulated by the lysine demethylase LSD1. |
| 17904127 |
SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. |
| 17967874 |
Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. |
| 18022393 |
Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. |
| 18206965 |
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. |
| 18249187 |
Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. |
| 18453682 |
Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 angstroms resolution. |
| 18585004 |
Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes. |
| 18650397 |
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. |
| 18996393 |
Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. |
| 19413330 |
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
| 19473992 |
Plk1-mediated phosphorylation of Topors regulates p53 stability. |
| 19509332 |
JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. |
| 19515728 |
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core. |
| 19536131 |
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. |
| 19556538 |
Trim24 targets endogenous p53 for degradation. |
| 19608861 |
Lysine acetylation targets protein complexes and co-regulates major cellular functions. |
| 19776115 |
Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein. |
| 19837670 |
MTA1 coregulator regulates p53 stability and function. |
| 19880522 |
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. |
| 20041275 |
Isoform specific phosphorylation of p53 by protein kinase CK1. |
| 20096447 |
USP10 regulates p53 localization and stability by deubiquitinating p53. |
| 20118233 |
G9a and Glp methylate lysine 373 in the tumor suppressor p53. |
| 20124405 |
G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis. |
| 20142040 |
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. |
| 20173098 |
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. |
| 20228809 |
BRD7 is a candidate tumour suppressor gene required for p53 function. |
| 20364130 |
Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. |
| 20385133 |
p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. |
| 20660729 |
Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. |
| 20673990 |
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. |
| 20870725 |
The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. |
| 20959462 |
Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| 21269460 |
Initial characterization of the human central proteome. |
| 21317932 |
A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation. |
| 21946351 |
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. |
| 21952639 |
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. |
| 22214662 |
The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest. |
| 22522597 |
Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses. |
| 22726440 |
p53 opens the mitochondrial permeability transition pore to trigger necrosis. |
| 22864287 |
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. |
| 22945289 |
ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis. |
| 23431171 |
MOZ increases p53 acetylation and premature senescence through its complex formation with PML. |
| 24051492 |
p53 regulates Period2 expression and the circadian clock. |
| 25422469 |
Disruption of FAT10-MAD2 binding inhibits tumor progression. |
| 25591766 |
RNF125 is a ubiquitin-protein ligase that promotes p53 degradation. |
| 25732823 |
DBC1 functions as a tumor suppressor by regulating p53 stability. |
| 25772236 |
PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. |
| 27323408 |
LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. |
