Protein: P10275 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P10275 (Uniprot)	ANDR_HUMAN	AR	Androgen receptor	human	No

Protein Function

Uniprot: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulate more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169, 187	GO:0034641	cellular nitrogen compound metabolic process	35	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
29	GO:0060255	regulation of macromolecule metabolic process
29	GO:0007165	signal transduction
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
111	GO:0006955	immune response
111	GO:0035556	intracellular signal transduction
111	GO:0009967	positive regulation of signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
29	GO:0005634	nucleus
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
155	GO:0005634	nucleus
165	GO:0005829	cytosol
165	GO:0043232	intracellular non-membrane-bounded organelle
165	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
GO:0001701	in utero embryonic development	IEA
GO:0003073	regulation of systemic arterial blood pressure	IEA
GO:0003382	epithelial cell morphogenesis	IEA
GO:0006351	transcription, DNA-templated	IDA
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS
GO:0006810	transport	TAS
GO:0007165	signal transduction	TAS
GO:0007267	cell-cell signaling	TAS
GO:0007283	spermatogenesis	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000790	nuclear chromatin	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IEA
GO:0016607	nuclear speck	IDA
GO:0043234	protein complex	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000790	nuclear chromatin	GO:0005737	cytoplasm	4.55e-08	5.17e-23
GO:0000790	nuclear chromatin	GO:0005886	plasma membrane	1.05e-21	5.03e-79
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005886	plasma membrane	GO:0016607	nuclear speck	2.37e-16	9.27e-101

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABL1_HUMAN	Yes: P00519 (MoonDB)
ABL2_HUMAN	Yes: P42684 (MoonDB)
ACTB_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
ARI5A_HUMAN	No
ARIP4_HUMAN	No
BLK_HUMAN	No
BLNK_HUMAN	No
BRCA1_HUMAN	No
BTK_HUMAN	No

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Publications Associated

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PMID	Article Title
1303262	A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome.
1307250	Androgen receptor gene mutations identified by SSCP in fourteen subjects with androgen insensitivity syndrome.
1316540	Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.
1424203	Point mutations detected in the androgen receptor gene of three men with partial androgen insensitivity syndrome.
1426313	A unique point mutation in the androgen receptor gene in a family with complete androgen insensitivity syndrome.
1430233	Mutations in the ligand-binding domain of the androgen receptor gene cluster in two regions of the gene.
1458719	Androgen resistance due to mutation of the androgen receptor.
1464650	Immunoreactive androgen receptor expression in subjects with androgen resistance.
1480178	Single base mutations in the human androgen receptor gene causing complete androgen insensitivity: rapid detection by a modified denaturing gradient gel electrophoresis technique.
1487249	Point mutation in the steroid-binding domain of the androgen receptor gene in a family with complete androgen insensitivity syndrome (CAIS).

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OMIM Diseases Associated

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OMIM ID	Disease Name
300068	Androgen insensitivity syndrome
312300	Androgen insensitivity, partial
313200	Spinal and bulbar muscular atrophy X-linked 1

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Protein Domains Associated

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Domain Name	Domain ID	Source
A39248	A39248	PIR
Andrgn_rcpt	IPR001103	InterPro
Androgen_recep	PF02166	Pfam
ANDROGENR	PR00521	PRINTS
HOLI	SM00430	SMART
Hormone_recep	PF00104	Pfam
NHR_like_dom_sf	IPR035500	InterPro
NR_LBD	PS51843	PROSITE
Nucl_hrmn_rcpt_lig-bd	IPR000536	InterPro
NUCLEAR_REC_DBD_1	PS00031	PROSITE

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