Protein: P63279

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P63279 (Uniprot) UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 human No
Uniprot: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 4, 169, 609 GO:0034641 cellular nitrogen compound metabolic process 504, 810 4.22e-144 6.90e-18
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 192, 270, 286, 384, 471 6.37e-04 1.88e-40
GO:0007165 signal transduction 4, 169, 609 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294 4.83e-02 1.79e-71
GO:0019538 protein metabolic process 197, 234 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
4 GO:0035556 intracellular signal transduction
4 GO:0031399 regulation of protein modification process
4 GO:0009966 regulation of signal transduction
7 GO:0031324 negative regulation of cellular metabolic process
7 GO:0010605 negative regulation of macromolecule metabolic process
7 GO:0051172 negative regulation of nitrogen compound metabolic process
7 GO:0010604 positive regulation of macromolecule metabolic process
7 GO:0006357 regulation of transcription from RNA polymerase II promoter
17 GO:0006355 regulation of transcription, DNA-templated
51 GO:0060255 regulation of macromolecule metabolic process
54 GO:0010467 gene expression
54 GO:0006139 nucleobase-containing compound metabolic process
54 GO:0060255 regulation of macromolecule metabolic process
99 GO:0031325 positive regulation of cellular metabolic process
99 GO:0010628 positive regulation of gene expression
99 GO:0051173 positive regulation of nitrogen compound metabolic process
99 GO:0019538 protein metabolic process
99 GO:0006357 regulation of transcription from RNA polymerase II promoter
99 GO:0007165 signal transduction
107 GO:0016070 RNA metabolic process
107 GO:0044267 cellular protein metabolic process
107 GO:0034654 nucleobase-containing compound biosynthetic process
107 GO:2000112 regulation of cellular macromolecule biosynthetic process
107 GO:0010468 regulation of gene expression
107 GO:0019219 regulation of nucleobase-containing compound metabolic process
107 GO:0007165 signal transduction
118 GO:0019538 protein metabolic process
118 GO:0060255 regulation of macromolecule metabolic process
118 GO:0007165 signal transduction
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
131 GO:0070647 protein modification by small protein conjugation or removal
131 GO:0006355 regulation of transcription, DNA-templated
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
191 GO:0006355 regulation of transcription, DNA-templated
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
197 GO:0044267 cellular protein metabolic process
197 GO:0060255 regulation of macromolecule metabolic process
201 GO:0006464 cellular protein modification process
201 GO:0031325 positive regulation of cellular metabolic process
201 GO:0010604 positive regulation of macromolecule metabolic process
201 GO:0051173 positive regulation of nitrogen compound metabolic process
201 GO:0010646 regulation of cell communication
201 GO:0023051 regulation of signaling
201 GO:0006355 regulation of transcription, DNA-templated
201 GO:0007165 signal transduction
207 GO:0007165 signal transduction
234 GO:0044267 cellular protein metabolic process
234 GO:0071310 cellular response to organic substance
234 GO:0033554 cellular response to stress
234 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
234 GO:0010629 negative regulation of gene expression
234 GO:0051172 negative regulation of nitrogen compound metabolic process
234 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
234 GO:0007165 signal transduction
244 GO:0006464 cellular protein modification process
244 GO:0060255 regulation of macromolecule metabolic process
244 GO:0007165 signal transduction
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
286 GO:0034645 cellular macromolecule biosynthetic process
286 GO:0090304 nucleic acid metabolic process
286 GO:0034654 nucleobase-containing compound biosynthetic process
286 GO:0010468 regulation of gene expression
294 GO:0000398 mRNA splicing, via spliceosome
300 GO:0016070 RNA metabolic process
300 GO:0044271 cellular nitrogen compound biosynthetic process
300 GO:0031325 positive regulation of cellular metabolic process
300 GO:0010604 positive regulation of macromolecule metabolic process
300 GO:0051173 positive regulation of nitrogen compound metabolic process
300 GO:2000112 regulation of cellular macromolecule biosynthetic process
300 GO:0010468 regulation of gene expression
300 GO:0019219 regulation of nucleobase-containing compound metabolic process
325 GO:0006355 regulation of transcription, DNA-templated
362 GO:0006464 cellular protein modification process
362 GO:0060255 regulation of macromolecule metabolic process
379 GO:0044267 cellular protein metabolic process
379 GO:0009059 macromolecule biosynthetic process
379 GO:0051246 regulation of protein metabolic process
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
394 GO:0006464 cellular protein modification process
394 GO:0031325 positive regulation of cellular metabolic process
394 GO:0010604 positive regulation of macromolecule metabolic process
394 GO:0051173 positive regulation of nitrogen compound metabolic process
394 GO:0032268 regulation of cellular protein metabolic process
394 GO:0006355 regulation of transcription, DNA-templated
394 GO:0007165 signal transduction
413 GO:0044267 cellular protein metabolic process
413 GO:0031326 regulation of cellular biosynthetic process
413 GO:0010468 regulation of gene expression
413 GO:0010556 regulation of macromolecule biosynthetic process
413 GO:0007165 signal transduction
413 GO:0006351 transcription, DNA-templated
420 GO:0006464 cellular protein modification process
446 GO:0007165 signal transduction
465 GO:0031325 positive regulation of cellular metabolic process
465 GO:0010604 positive regulation of macromolecule metabolic process
465 GO:0051173 positive regulation of nitrogen compound metabolic process
465 GO:0006357 regulation of transcription from RNA polymerase II promoter
465 GO:0007165 signal transduction
471 GO:0034645 cellular macromolecule biosynthetic process
471 GO:0044271 cellular nitrogen compound biosynthetic process
471 GO:0006464 cellular protein modification process
471 GO:0031324 negative regulation of cellular metabolic process
471 GO:0010605 negative regulation of macromolecule metabolic process
471 GO:0010604 positive regulation of macromolecule metabolic process
471 GO:0051173 positive regulation of nitrogen compound metabolic process
471 GO:0051252 regulation of RNA metabolic process
471 GO:0010468 regulation of gene expression
471 GO:0007165 signal transduction
504 GO:0044271 cellular nitrogen compound biosynthetic process
504 GO:0044267 cellular protein metabolic process
504 GO:0031324 negative regulation of cellular metabolic process
504 GO:0010629 negative regulation of gene expression
504 GO:0051172 negative regulation of nitrogen compound metabolic process
504 GO:0051252 regulation of RNA metabolic process
504 GO:2000112 regulation of cellular macromolecule biosynthetic process
521 GO:0060255 regulation of macromolecule metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
602 GO:0006464 cellular protein modification process
606 GO:0019538 protein metabolic process
606 GO:0006355 regulation of transcription, DNA-templated
606 GO:0007165 signal transduction
606 GO:0006366 transcription from RNA polymerase II promoter
609 GO:0007166 cell surface receptor signaling pathway
609 GO:0006464 cellular protein modification process
609 GO:0071310 cellular response to organic substance
609 GO:0031325 positive regulation of cellular metabolic process
609 GO:0010604 positive regulation of macromolecule metabolic process
609 GO:0051173 positive regulation of nitrogen compound metabolic process
609 GO:0051246 regulation of protein metabolic process
609 GO:0006355 regulation of transcription, DNA-templated
626 GO:0006915 apoptotic process
626 GO:0044267 cellular protein metabolic process
626 GO:0071310 cellular response to organic substance
626 GO:0051253 negative regulation of RNA metabolic process
626 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
626 GO:0010629 negative regulation of gene expression
626 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
626 GO:0010941 regulation of cell death
626 GO:0009966 regulation of signal transduction
626 GO:0009719 response to endogenous stimulus
643 GO:0044267 cellular protein metabolic process
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
674 GO:0006464 cellular protein modification process
674 GO:0031324 negative regulation of cellular metabolic process
674 GO:0010605 negative regulation of macromolecule metabolic process
674 GO:0051172 negative regulation of nitrogen compound metabolic process
674 GO:0010604 positive regulation of macromolecule metabolic process
674 GO:2000112 regulation of cellular macromolecule biosynthetic process
674 GO:0010468 regulation of gene expression
674 GO:1903506 regulation of nucleic acid-templated transcription
674 GO:0007165 signal transduction
674 GO:0006351 transcription, DNA-templated
679 GO:0031325 positive regulation of cellular metabolic process
679 GO:0010604 positive regulation of macromolecule metabolic process
679 GO:0051173 positive regulation of nitrogen compound metabolic process
679 GO:0006357 regulation of transcription from RNA polymerase II promoter
679 GO:0007165 signal transduction
716 GO:0010646 regulation of cell communication
716 GO:0023051 regulation of signaling
716 GO:0007165 signal transduction
720 GO:0006464 cellular protein modification process
720 GO:0071310 cellular response to organic substance
720 GO:0006355 regulation of transcription, DNA-templated
720 GO:0006366 transcription from RNA polymerase II promoter
725 GO:0051252 regulation of RNA metabolic process
725 GO:0010468 regulation of gene expression
728 GO:0044267 cellular protein metabolic process
728 GO:0031325 positive regulation of cellular metabolic process
728 GO:0010604 positive regulation of macromolecule metabolic process
728 GO:0051173 positive regulation of nitrogen compound metabolic process
728 GO:0051252 regulation of RNA metabolic process
728 GO:0010468 regulation of gene expression
728 GO:0007165 signal transduction
742 GO:0031325 positive regulation of cellular metabolic process
742 GO:0010604 positive regulation of macromolecule metabolic process
742 GO:0051173 positive regulation of nitrogen compound metabolic process
742 GO:0006357 regulation of transcription from RNA polymerase II promoter
753 GO:0044267 cellular protein metabolic process
753 GO:0034654 nucleobase-containing compound biosynthetic process
753 GO:0031325 positive regulation of cellular metabolic process
753 GO:0010604 positive regulation of macromolecule metabolic process
753 GO:0051173 positive regulation of nitrogen compound metabolic process
753 GO:0031326 regulation of cellular biosynthetic process
753 GO:0019219 regulation of nucleobase-containing compound metabolic process
753 GO:0009966 regulation of signal transduction
754 GO:0010605 negative regulation of macromolecule metabolic process
754 GO:0051252 regulation of RNA metabolic process
754 GO:0010468 regulation of gene expression
754 GO:0006366 transcription from RNA polymerase II promoter
758 GO:0016070 RNA metabolic process
758 GO:0034645 cellular macromolecule biosynthetic process
758 GO:0044271 cellular nitrogen compound biosynthetic process
758 GO:0044267 cellular protein metabolic process
758 GO:0009893 positive regulation of metabolic process
758 GO:0010468 regulation of gene expression
758 GO:0019219 regulation of nucleobase-containing compound metabolic process
780 GO:0006355 regulation of transcription, DNA-templated
810 GO:0044271 cellular nitrogen compound biosynthetic process
810 GO:0006139 nucleobase-containing compound metabolic process
810 GO:2000112 regulation of cellular macromolecule biosynthetic process
810 GO:0010468 regulation of gene expression
823 GO:0044267 cellular protein metabolic process
823 GO:0071310 cellular response to organic substance
823 GO:0010629 negative regulation of gene expression
823 GO:0031325 positive regulation of cellular metabolic process
823 GO:0010628 positive regulation of gene expression
823 GO:0051173 positive regulation of nitrogen compound metabolic process
823 GO:0006357 regulation of transcription from RNA polymerase II promoter
823 GO:0007165 signal transduction
841 GO:0044267 cellular protein metabolic process
841 GO:0009059 macromolecule biosynthetic process
841 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
4 GO:0005829 cytosol
4 GO:0005634 nucleus
7 GO:0005654 nucleoplasm
17 GO:0005829 cytosol
17 GO:0005654 nucleoplasm
51 GO:0005634 nucleus
54 GO:0070013 intracellular organelle lumen
54 GO:0005634 nucleus
99 GO:0005654 nucleoplasm
107 GO:0005829 cytosol
107 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
131 GO:0005829 cytosol
131 GO:0043232 intracellular non-membrane-bounded organelle
131 GO:0005634 nucleus
155 GO:0005634 nucleus
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
191 GO:0031981 nuclear lumen
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
201 GO:0005829 cytosol
201 GO:0005654 nucleoplasm
207 GO:0005829 cytosol
207 GO:0005654 nucleoplasm
234 GO:0012505 endomembrane system
234 GO:0005654 nucleoplasm
244 GO:0005829 cytosol
244 GO:0043232 intracellular non-membrane-bounded organelle
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
286 GO:0044428 nuclear part
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
300 GO:0070013 intracellular organelle lumen
300 GO:0044428 nuclear part
325 GO:0005829 cytosol
325 GO:0043232 intracellular non-membrane-bounded organelle
325 GO:0005654 nucleoplasm
362 GO:0070013 intracellular organelle lumen
362 GO:0005634 nucleus
379 GO:0005829 cytosol
379 GO:0005576 extracellular region
379 GO:0005634 nucleus
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
394 GO:0005654 nucleoplasm
413 GO:0005654 nucleoplasm
420 GO:0005829 cytosol
420 GO:0005634 nucleus
465 GO:0005654 nucleoplasm
471 GO:0005654 nucleoplasm
504 GO:0005654 nucleoplasm
521 GO:0070013 intracellular organelle lumen
521 GO:0005634 nucleus
525 GO:0005829 cytosol
575 GO:0005654 nucleoplasm
602 GO:0005634 nucleus
604 GO:0005829 cytosol
604 GO:0043232 intracellular non-membrane-bounded organelle
604 GO:0005634 nucleus
606 GO:0005829 cytosol
606 GO:0031981 nuclear lumen
609 GO:0005829 cytosol
609 GO:0043232 intracellular non-membrane-bounded organelle
609 GO:0070013 intracellular organelle lumen
609 GO:0005634 nucleus
609 GO:0005886 plasma membrane
626 GO:0005829 cytosol
626 GO:0005654 nucleoplasm
643 GO:0005634 nucleus
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
674 GO:0005829 cytosol
674 GO:0043232 intracellular non-membrane-bounded organelle
674 GO:0005654 nucleoplasm
679 GO:0031981 nuclear lumen
716 GO:0016021 integral component of membrane
716 GO:0005886 plasma membrane
720 GO:0005829 cytosol
720 GO:0005654 nucleoplasm
725 GO:0005829 cytosol
725 GO:0031981 nuclear lumen
728 GO:0005829 cytosol
728 GO:0005634 nucleus
742 GO:0005654 nucleoplasm
753 GO:0005634 nucleus
754 GO:0005654 nucleoplasm
758 GO:0005654 nucleoplasm
780 GO:0005654 nucleoplasm
800 GO:0005654 nucleoplasm
810 GO:0044428 nuclear part
812 GO:0005634 nucleus
823 GO:0005829 cytosol
823 GO:0005654 nucleoplasm
841 GO:0005829 cytosol
841 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS
GO:0006464 cellular protein modification process TAS
GO:0006511 ubiquitin-dependent protein catabolic process TAS
GO:0007049 cell cycle IEA
GO:0007059 chromosome segregation IEA
GO:0010469 regulation of receptor activity IEA
GO:0016032 viral process IEA
GO:0016567 protein ubiquitination IEA
GO:0016925 protein sumoylation TAS
GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway IEA
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0051091 positive regulation of DNA binding transcription factor activity IEA
GO:0051301 cell division IEA
GO:0070911 global genome nucleotide-excision repair TAS
GO:1903755 positive regulation of SUMO transferase activity IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000795 synaptonemal complex TAS
GO:0001650 fibrillar center IEA
GO:0005634 nucleus IDA
GO:0005635 nuclear envelope TAS
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0016605 PML body IDA
GO:0030425 dendrite IEA
GO:0045202 synapse IEA
GO:1990234 transferase complex IDA
GO:1990356 sumoylated E2 ligase complex IC
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0045202 synapse 1.10e-08 8.94e-15
GO:0005654 nucleoplasm GO:0045202 synapse 3.30e-10 4.22e-25
GO:0045202 synapse GO:1990234 transferase complex 7.78e-03 4.87e-24
Interactor Also a MoonDB EMF protein
G2XKQ0_HUMAN No
ZBED1_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
KAP1_HUMAN No
KLH12_HUMAN No
ZBT8A_HUMAN No
TRI54_HUMAN No
IKZF3_HUMAN No
BAG3_HUMAN No
RBTN2_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
BIRC7_HUMAN No
FHL3_HUMAN No
CTBP2_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
ATX1_HUMAN Yes: P54253 (MoonDB)
RHXF2_HUMAN No
GMCL1_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
TFCP2_HUMAN No
SETBP_HUMAN Yes: Q9Y6X0 (MoonDB)
IKBA_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
IKZF1_HUMAN No
HGS_HUMAN No
TF7L2_HUMAN No
AAPK2_HUMAN No
HDAC4_HUMAN No
FMR1_HUMAN No
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
SUMO3_HUMAN No
HSF2_HUMAN No
NUDC3_HUMAN No
PDLI7_HUMAN No
AP2A_HUMAN No
MISSL_HUMAN No
DESM_HUMAN No
DAXX_HUMAN No
PCH2_HUMAN No
DZIP3_HUMAN No
SNIP1_HUMAN Yes: Q8TAD8 (MoonDB)
SETB1_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
NMI_HUMAN No
CEBPE_HUMAN No
K1C19_HUMAN No
WT1_HUMAN No
CLD2_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
HNRPK_HUMAN Yes: P61978 (MoonDB)
PPARG_HUMAN Yes: P37231 (MoonDB)
RN111_HUMAN Yes: Q6ZNA4 (MoonDB)
ZYX_HUMAN No
CYTSA_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
AP2B_HUMAN No
AP2C_HUMAN No
APEX1_HUMAN No
ARIP4_HUMAN No
ASF1B_HUMAN No
ATF2_HUMAN No
ATP8_HUMAN No
ATRAP_HUMAN No
BEND5_HUMAN No
BIRC3_HUMAN No
BLMH_HUMAN No
BLM_HUMAN No
BMI1_HUMAN No
BOREA_HUMAN No
BRCA1_HUMAN No
BRD7_HUMAN No
BRE1B_HUMAN No
C8AP2_HUMAN No
CARM1_HUMAN No
CASP2_HUMAN No
CBLC_HUMAN No
CBSL_HUMAN No
CHD3_HUMAN Yes: Q12873 (MoonDB)
CHM1A_HUMAN Yes: Q9HD42 (MoonDB)
CHM4B_HUMAN No
CHMP5_HUMAN No
CLH1_HUMAN Yes: Q00610 (MoonDB)
CLK2_HUMAN No
CR025_HUMAN No
CREB1_HUMAN No
CREM_HUMAN No
CSDE1_HUMAN No
CSEN_HUMAN No
CSN5_HUMAN No
DACH1_HUMAN No
DHX9_HUMAN No
DNM3A_HUMAN No
DNM3B_HUMAN No
DTX3L_HUMAN No
DYN1_HUMAN No
EDAD_HUMAN No
EGR2_HUMAN No
ESR1_HUMAN Yes: P03372 (MoonDB)
ETS1_HUMAN Yes: P14921 (MoonDB)
ETV6_HUMAN No
EXOS9_HUMAN No
FHIT_HUMAN No
FLI1_HUMAN No
FLNC_HUMAN No
FSBP_HUMAN No
GLNA_HUMAN No
GMEB1_HUMAN No
GOGB1_HUMAN No
GRIP1_HUMAN No
HABP4_HUMAN No
HDAC5_HUMAN No
HIPK1_HUMAN No
HIPK2_HUMAN No
HIPK3_HUMAN No
HNF4A_HUMAN No
HNRLL_HUMAN No
HNRPC_HUMAN No
HNRPD_HUMAN Yes: Q14103 (MoonDB)
IPO13_HUMAN No
JUN_HUMAN No
KAP0_HUMAN No
KCTD1_HUMAN No
KMT5A_HUMAN No
KTN1_HUMAN No
LMNA_HUMAN No
LNX2_HUMAN Yes: Q8N448 (MoonDB)
M3K1_HUMAN No
MARH5_HUMAN No
MCAF1_HUMAN No
MCR_HUMAN No
MEF2A_HUMAN No
MGRN1_HUMAN No
MITF_HUMAN No
MX1_HUMAN No
MYB_HUMAN No
NFAC1_HUMAN No
NHRF3_HUMAN No
NR1H2_HUMAN Yes: P55055 (MoonDB)
NSD3_HUMAN No
NVL_HUMAN No
P63_HUMAN No
P73_HUMAN No
PARK7_HUMAN No
PARP1_HUMAN No
PELI1_HUMAN No
PEX10_HUMAN No
PHC1_HUMAN No
PHF19_HUMAN No
PIAS1_HUMAN No
PIAS2_HUMAN No
PIAS3_HUMAN No
PIAS4_HUMAN No
PININ_HUMAN No
PLAL1_HUMAN No
PML_HUMAN No
PR40A_HUMAN Yes: O75400 (MoonDB)
PRKRA_HUMAN No
PUF60_HUMAN No
R144B_HUMAN No
RA54B_HUMAN No
RAD18_HUMAN No
RAD51_HUMAN No
RAD52_HUMAN No
RAGP1_HUMAN No
RANB9_HUMAN No
RBBP6_HUMAN No
RBP2_HUMAN No
RC3H2_HUMAN No
RCBT2_HUMAN No
RFPL3_HUMAN No
RIPK2_HUMAN No
RN115_HUMAN Yes: Q9Y4L5 (MoonDB)
RN128_HUMAN No
RN133_HUMAN No
RN185_HUMAN No
RNF10_HUMAN No
RNF4_HUMAN No
RO52_HUMAN No
RORB_HUMAN No
SALL1_HUMAN No
SATB1_HUMAN No
SCNNA_HUMAN No
SETX_HUMAN No
SIAH2_HUMAN No
SKIL_HUMAN No
SL9A1_HUMAN No
SMAD4_HUMAN No
SOCS6_HUMAN No
SOX10_HUMAN No
SOX4_HUMAN No
SP100_HUMAN No
SRBP2_HUMAN No
SUMO1_HUMAN Yes: P63165 (MoonDB)
SUMO2_HUMAN No
T22D1_HUMAN No
TFE2_HUMAN No
TITIN_HUMAN Yes: Q8WZ42 (MoonDB)
TNR1A_HUMAN No
TNR6A_HUMAN No
TNR6_HUMAN No
TOP1_HUMAN No
TOP2B_HUMAN No
TOPRS_HUMAN No
TRAF3_HUMAN Yes: Q13114 (MoonDB)
TRI23_HUMAN No
TRI29_HUMAN No
TRI38_HUMAN No
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
TRI55_HUMAN No
TRI63_HUMAN No
TRI72_HUMAN No
TRPS1_HUMAN No
TYDP2_HUMAN No
U119A_HUMAN No
UBXN1_HUMAN No
UCHL1_HUMAN No
UIMC1_HUMAN No
WNK2_HUMAN No
XBP1_HUMAN No
ZBT26_HUMAN No
ZCHC7_HUMAN No
ZHX1_HUMAN No
ZMY11_HUMAN No
ZMYM2_HUMAN No
ZN106_HUMAN No
ZN451_HUMAN No
ZN646_HUMAN No
PMID Article Title
8565643 Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle.
8610150 Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.
8668125 Two-hybrid interaction of a human UBC9 homolog with centromere proteins of Saccharomyces cerevisiae.
8668529 Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9.
8798754 Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9.
8824223 mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect.
9067428 Assignment of the gene for a ubiquitin-conjugating enzyme (UBE2I) to human chromosome band 16p13.3 by in situ hybridization.
9197546 Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9.
9261152 Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.
9333025 Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme.
9334332 Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
10383460 Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription.
11085938 Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.
11157797 Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
11451954 Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.
11853669 Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.
12072434 Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
12641448 Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex.
12924945 Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.
15378033 The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15608651 Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.
15616553 The sequence and analysis of duplication-rich human chromosome 16.
15809060 Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.
15931224 Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.
16620772 A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.
16631117 Ubc9 interacts with SOX4 and represses its transcriptional activity.
16732283 Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
17005699 Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation.
17466333 Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction.
17704809 Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response.
17956732 RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19450230 SUMOylation enhances DNA methyltransferase 1 activity.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19638400 SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle.
19744555 Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the steroidogenic acute regulatory gene.
20077568 Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45.
20543865 Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation.
21139563 Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation.
21269460 Initial characterization of the human central proteome.
21795333 Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9.
21965678 SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.
22214662 The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest.
22509284 Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23404503 UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.
23469069 In silico structural and functional characterization of the RSUME splice variants.
23508108 RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity.
24105744 A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
25772364 SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
25918163 RWD domain as an E2 (Ubc9)-interaction module.
25944712 N-terminome analysis of the human mitochondrial proteome.
26524494 Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
Ubc9 IPR027230 InterPro
JC6056 JC6056 PIR
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
PTHR43927 PTHR43927 PANTHER
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD