Protein: P14373

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P14373 (Uniprot) TRI27_HUMAN TRIM27 Zinc finger protein RFP human No
Uniprot: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 359 GO:0009059 macromolecule biosynthetic process 5, 797 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
5 GO:0034645 cellular macromolecule biosynthetic process
5 GO:0006464 cellular protein modification process
5 GO:0090304 nucleic acid metabolic process
5 GO:0034654 nucleobase-containing compound biosynthetic process
5 GO:0060255 regulation of macromolecule metabolic process
44 GO:0010467 gene expression
44 GO:0031324 negative regulation of cellular metabolic process
44 GO:0009889 regulation of biosynthetic process
44 GO:0060255 regulation of macromolecule metabolic process
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
59 GO:0016070 RNA metabolic process
59 GO:0006464 cellular protein modification process
59 GO:0010467 gene expression
59 GO:2000112 regulation of cellular macromolecule biosynthetic process
67 GO:0060255 regulation of macromolecule metabolic process
94 GO:0006464 cellular protein modification process
94 GO:0060255 regulation of macromolecule metabolic process
131 GO:0070647 protein modification by small protein conjugation or removal
131 GO:0006355 regulation of transcription, DNA-templated
280 GO:0016070 RNA metabolic process
280 GO:0010467 gene expression
351 GO:0022402 cell cycle process
351 GO:0034645 cellular macromolecule biosynthetic process
351 GO:0044267 cellular protein metabolic process
351 GO:0090304 nucleic acid metabolic process
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
452 GO:0090304 nucleic acid metabolic process
452 GO:0010468 regulation of gene expression
452 GO:0007165 signal transduction
458 GO:0006139 nucleobase-containing compound metabolic process
476 GO:0010467 gene expression
476 GO:0060255 regulation of macromolecule metabolic process
499 GO:0006464 cellular protein modification process
499 GO:0060255 regulation of macromolecule metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
596 GO:0006464 cellular protein modification process
603 GO:0060255 regulation of macromolecule metabolic process
606 GO:0019538 protein metabolic process
606 GO:0006355 regulation of transcription, DNA-templated
606 GO:0007165 signal transduction
606 GO:0006366 transcription from RNA polymerase II promoter
620 GO:0019538 protein metabolic process
620 GO:0006355 regulation of transcription, DNA-templated
620 GO:0006366 transcription from RNA polymerase II promoter
713 GO:0090304 nucleic acid metabolic process
713 GO:0070647 protein modification by small protein conjugation or removal
713 GO:0007165 signal transduction
791 GO:0060255 regulation of macromolecule metabolic process
797 GO:0034645 cellular macromolecule biosynthetic process
797 GO:0060255 regulation of macromolecule metabolic process
818 GO:0070647 protein modification by small protein conjugation or removal
818 GO:0006355 regulation of transcription, DNA-templated
818 GO:0007165 signal transduction
859 GO:0010467 gene expression
859 GO:0090304 nucleic acid metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
5 GO:0005829 cytosol
5 GO:0005634 nucleus
44 GO:0005829 cytosol
44 GO:0005634 nucleus
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
59 GO:0005634 nucleus
67 GO:0005634 nucleus
82 GO:0005634 nucleus
84 GO:0005634 nucleus
89 GO:0005634 nucleus
131 GO:0005829 cytosol
131 GO:0043232 intracellular non-membrane-bounded organelle
131 GO:0005634 nucleus
231 GO:0005634 nucleus
280 GO:0005634 nucleus
351 GO:0043232 intracellular non-membrane-bounded organelle
351 GO:0005654 nucleoplasm
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
452 GO:0005829 cytosol
452 GO:0070013 intracellular organelle lumen
452 GO:0044428 nuclear part
458 GO:0005634 nucleus
466 GO:0005829 cytosol
476 GO:0005634 nucleus
499 GO:0005829 cytosol
499 GO:0031981 nuclear lumen
523 GO:0005829 cytosol
523 GO:0031982 vesicle
575 GO:0005654 nucleoplasm
596 GO:0005634 nucleus
603 GO:0005634 nucleus
606 GO:0005829 cytosol
606 GO:0031981 nuclear lumen
611 GO:0005634 nucleus
620 GO:0031981 nuclear lumen
630 GO:0005829 cytosol
630 GO:0043232 intracellular non-membrane-bounded organelle
630 GO:0005634 nucleus
713 GO:0005829 cytosol
713 GO:0005634 nucleus
721 GO:0043232 intracellular non-membrane-bounded organelle
721 GO:0005634 nucleus
739 GO:0043232 intracellular non-membrane-bounded organelle
739 GO:0005654 nucleoplasm
791 GO:0005634 nucleus
797 GO:0043232 intracellular non-membrane-bounded organelle
797 GO:0005634 nucleus
818 GO:0005829 cytosol
859 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0002820 negative regulation of adaptive immune response IMP
GO:0006351 transcription, DNA-templated IEA
GO:0006469 negative regulation of protein kinase activity IDA
GO:0007283 spermatogenesis TAS
GO:0008283 cell proliferation TAS
GO:0018108 peptidyl-tyrosine phosphorylation IEA
GO:0032720 negative regulation of tumor necrosis factor production IMP
GO:0032897 negative regulation of viral transcription IDA
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA
GO:0042147 retrograde transport, endosome to Golgi IDA
GO:0045087 innate immune response IDA
GO:0045814 negative regulation of gene expression, epigenetic IDA
GO:0051091 positive regulation of DNA binding transcription factor activity IDA
GO:0070206 protein trimerization IDA
GO:0070534 protein K63-linked ubiquitination IMP
GO:0072643 interferon-gamma secretion IMP
GO:0090281 negative regulation of calcium ion import IMP
GO:1900041 negative regulation of interleukin-2 secretion IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0001650 fibrillar center IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm IDA
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005768 endosome IDA
GO:0005769 early endosome IEA
GO:0005829 cytosol TAS
GO:0005887 integral component of plasma membrane TAS
GO:0016020 membrane TAS
GO:0016605 PML body IEA
GO:0030904 retromer complex IDA
GO:0031965 nuclear membrane IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005768 endosome 4.09e-12 7.34e-15
GO:0005634 nucleus GO:0005887 integral component of plasma membrane 6.41e-134 1.88e-259
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005654 nucleoplasm GO:0005768 endosome 1.29e-11 1.85e-14
GO:0005654 nucleoplasm GO:0005769 early endosome 5.29e-05 1.04e-19
GO:0005654 nucleoplasm GO:0005887 integral component of plasma membrane 3.07e-87 3.74e-184
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0005730 nucleolus GO:0005887 integral component of plasma membrane 3.40e-17 3.71e-07
GO:0005730 nucleolus GO:0016020 membrane 8.89e-46 1.83e-10
GO:0005737 cytoplasm GO:0005887 integral component of plasma membrane 4.51e-73 1.63e-08
GO:0005829 cytosol GO:0005887 integral component of plasma membrane 1.94e-100 1.70e-71
GO:0016020 membrane GO:0016605 PML body 9.16e-06 6.11e-17
Interactor Also a MoonDB EMF protein
PRP31_HUMAN No
TPM3_HUMAN No
ARI5A_HUMAN No
ENKD1_HUMAN No
A0A024R8L2_HUMAN No
VINEX_HUMAN No
K2C75_HUMAN No
AAPK1_HUMAN No
AB17A_HUMAN No
ABCF3_HUMAN No
ACSF3_HUMAN No
AEN_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
AMOL2_HUMAN No
AP1M1_HUMAN No
ARHG3_HUMAN No
ARHG5_HUMAN No
ARI2_HUMAN No
ARMC7_HUMAN No
ARNT2_HUMAN No
ARPIN_HUMAN No
ATPF2_HUMAN No
ATX7_HUMAN No
BABA1_HUMAN No
BAG1_HUMAN No
BAG3_HUMAN No
BAG5_HUMAN No
BCL6_HUMAN No
BEGIN_HUMAN No
BEX2_HUMAN No
BMI1_HUMAN No
BMP7_HUMAN No
BYST_HUMAN No
C0H5X2_HUMAN No
C102B_HUMAN No
C19L2_HUMAN No
CA109_HUMAN No
CAN7_HUMAN No
CAR10_HUMAN No
CASL_HUMAN No
CBX8_HUMAN No
CC185_HUMAN No
CCD87_HUMAN No
CCD92_HUMAN No
CCD94_HUMAN No
CCHCR_HUMAN No
CD20B_HUMAN No
CDC23_HUMAN No
CDC7_HUMAN No
CDK18_HUMAN No
CDKL3_HUMAN No
CF206_HUMAN No
CHD4_HUMAN No
CKS1_HUMAN No
CLK2_HUMAN No
CN105_HUMAN No
CNNM3_HUMAN No
COX5B_HUMAN No
CPNE2_HUMAN No
CPNE7_HUMAN No
CPSF5_HUMAN No
CR018_HUMAN No
CREB5_HUMAN No
CSR2B_HUMAN No
CSRP2_HUMAN No
CTSR1_HUMAN No
DBF4B_HUMAN No
DCX_HUMAN No
DDX6_HUMAN No
DGCR6_HUMAN No
DMRT3_HUMAN No
DNMT1_HUMAN No
DPOE2_HUMAN No
DTBP1_HUMAN No
DTNB_HUMAN No
ECHP_HUMAN No
EIF3D_HUMAN No
EIF3E_HUMAN No
EPC1_HUMAN No
ERCC3_HUMAN No
EXOC8_HUMAN No
F110A_HUMAN No
F126B_HUMAN No
F161A_HUMAN No
F193B_HUMAN No
F214A_HUMAN No
F214B_HUMAN No
F90A1_HUMAN No
FA83A_HUMAN No
FAKD5_HUMAN No
FANCG_HUMAN Yes: O15287 (MoonDB)
FANCM_HUMAN No
FBF1_HUMAN No
FBXW5_HUMAN No
FHL3_HUMAN No
FND11_HUMAN No
FOXB1_HUMAN No
FOXC2_HUMAN No
FXL19_HUMAN No
FXYD6_HUMAN No
G3V1X1_HUMAN No
G45IP_HUMAN No
GA2L2_HUMAN No
GCP4_HUMAN No
GEM_HUMAN No
GFAP_HUMAN No
GFI1B_HUMAN No
GLCNE_HUMAN No
GLCTK_HUMAN No
GNPI2_HUMAN No
GPAN1_HUMAN No
GPKOW_HUMAN No
GRB14_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
GSE1_HUMAN No
HAIR_HUMAN No
HAUS1_HUMAN No
HCK_HUMAN No
HDAC4_HUMAN No
HGS_HUMAN No
HIP1R_HUMAN No
HPLN2_HUMAN No
HXB5_HUMAN No
HXB9_HUMAN No
HXC8_HUMAN No
IF4A3_HUMAN No
IF4E2_HUMAN No
IF4E_HUMAN No
IGFN1_HUMAN No
IKKE_HUMAN No
IL16_HUMAN No
ILF2_HUMAN No
ILK_HUMAN No
IN80B_HUMAN No
IP6K3_HUMAN No
IQCE_HUMAN No
IQUB_HUMAN No
JOS1_HUMAN No
K1683_HUMAN No
K22O_HUMAN No
K2C1_HUMAN No
K2C3_HUMAN No
KANL1_HUMAN No
KAT5_HUMAN No
KCD15_HUMAN No
KCTD9_HUMAN No
KIF1A_HUMAN No
KIF9_HUMAN No
KIFC3_HUMAN No
LAGE3_HUMAN No
LASP1_HUMAN No
LENG1_HUMAN No
LIGO1_HUMAN No
LMNB2_HUMAN No
LMO4_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
LONF1_HUMAN No
MABP1_HUMAN No
MAGAB_HUMAN Yes: P43364 (MoonDB)
MAT2B_HUMAN No
MBD4_HUMAN No
MCLN1_HUMAN No
MCM7_HUMAN No
MD1L1_HUMAN No
MD2L2_HUMAN No
MED21_HUMAN No
MEMO1_HUMAN No
MGN2_HUMAN No
MIC19_HUMAN No
MOS_HUMAN No
MSRB1_HUMAN No
MTMR6_HUMAN No
MVP_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
NCOA1_HUMAN No
NDE1_HUMAN No
NDEL1_HUMAN Yes: Q9GZM8 (MoonDB)
NDK7_HUMAN No
NEBL_HUMAN No
NEIL2_HUMAN No
NEK6_HUMAN No
NELFE_HUMAN No
NIF3L_HUMAN No
NOD2_HUMAN No
NR1D2_HUMAN No
NT2NL_HUMAN No
NTAQ1_HUMAN Yes: Q96HA8 (MoonDB)
OAS1_HUMAN No
OTUB2_HUMAN No
P121A_HUMAN No
P2RX7_HUMAN No
P3C2B_HUMAN No
P66B_HUMAN No
PEPL_HUMAN No
PI5PA_HUMAN No
PIAS1_HUMAN No
PIAS2_HUMAN No
PIAS3_HUMAN No
PIAS4_HUMAN No
PIBF1_HUMAN No
PIMRE_HUMAN No
PIN1_HUMAN No
PKHN1_HUMAN No
PKN1_HUMAN No
PPID_HUMAN No
PPL13_HUMAN No
PPR18_HUMAN No
PRAM_HUMAN No
PRP18_HUMAN No
PRR35_HUMAN No
PSA1_HUMAN No
PSB1_HUMAN No
PSB3_HUMAN No
PTN23_HUMAN No
PTPM1_HUMAN No
PUS7L_HUMAN No
Q05CH4_HUMAN No
Q0P5Q0_HUMAN No
Q6NSM0_HUMAN No
Q6NXQ0_HUMAN No
Q8IVT4_HUMAN No
RAB7L_HUMAN No
RAM_HUMAN No
RBM23_HUMAN No
RBM41_HUMAN No
RBTN1_HUMAN No
RBX1_HUMAN No
RB_HUMAN No
RCOR3_HUMAN No
REL_HUMAN No
RHPN1_HUMAN No
RIBC1_HUMAN No
RIN1_HUMAN No
RM40_HUMAN No
RN213_HUMAN No
RNF25_HUMAN No
RO52_HUMAN No
RPAC1_HUMAN No
RPC3_HUMAN No
RRF2M_HUMAN No
RSP14_HUMAN No
RU2B_HUMAN No
S15A3_HUMAN No
SCNM1_HUMAN No
SDCB1_HUMAN Yes: O00560 (MoonDB)
SH24A_HUMAN No
SHPS1_HUMAN No
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
SMG9_HUMAN No
SMRD1_HUMAN No
SNRPA_HUMAN No
SPAT2_HUMAN No
SPC1L_HUMAN No
SRSF2_HUMAN No
STALP_HUMAN No
STK16_HUMAN No
STK25_HUMAN No
STK26_HUMAN No
SYFM_HUMAN No
SYGP1_HUMAN No
SYQ_HUMAN No
SYT17_HUMAN No
SYT6_HUMAN No
T10IP_HUMAN No
T2FA_HUMAN No
TACO1_HUMAN No
TB22B_HUMAN No
TBK1_HUMAN No
TCEA2_HUMAN No
TCHP_HUMAN No
TEAD4_HUMAN No
TEANC_HUMAN No
TENS4_HUMAN No
TEX33_HUMAN No
TGO1_HUMAN No
THOC1_HUMAN No
TPRKB_HUMAN No
TRAF4_HUMAN No
TRAF5_HUMAN No
TRI11_HUMAN No
TRI18_HUMAN No
TRI23_HUMAN No
TRI29_HUMAN No
TRI31_HUMAN No
TRI32_HUMAN No
TRI42_HUMAN No
TRI43_HUMAN No
TRI50_HUMAN No
TRI55_HUMAN No
TRIM1_HUMAN Yes: Q9UJV3 (MoonDB)
TRIM8_HUMAN Yes: Q9BZR9 (MoonDB)
TRIM9_HUMAN No
TSH3_HUMAN No
TTL10_HUMAN No
TUFT1_HUMAN No
TXND9_HUMAN No
TYB4_HUMAN Yes: P62328 (MoonDB)
UB2D1_HUMAN Yes: P51668 (MoonDB)
UB2D2_HUMAN Yes: P62837 (MoonDB)
UB2D3_HUMAN Yes: P61077 (MoonDB)
UB2D4_HUMAN Yes: Q9Y2X8 (MoonDB)
UB2E1_HUMAN Yes: P51965 (MoonDB)
UB2E2_HUMAN Yes: Q96LR5 (MoonDB)
UB2E3_HUMAN Yes: Q969T4 (MoonDB)
UB2J1_HUMAN No
UB2L6_HUMAN No
UBC9_HUMAN Yes: P63279 (MoonDB)
UBE2A_HUMAN No
UBE2H_HUMAN Yes: P62256 (MoonDB)
UBE2K_HUMAN Yes: P61086 (MoonDB)
UBE2N_HUMAN Yes: P61088 (MoonDB)
UBE2O_HUMAN Yes: Q9C0C9 (MoonDB)
UBE2T_HUMAN No
UBE2U_HUMAN Yes: Q5VVX9 (MoonDB)
UBE2W_HUMAN Yes: Q96B02 (MoonDB)
UBE2Z_HUMAN No
UBL5_HUMAN No
UBP2_HUMAN Yes: O75604 (MoonDB)
UBP7_HUMAN No
UBS3A_HUMAN No
UCHL3_HUMAN No
UCHL5_HUMAN No
UHRF2_HUMAN No
USE1_HUMAN No
UT14C_HUMAN No
UTP23_HUMAN No
VEZF1_HUMAN No
VP9D1_HUMAN No
VPS25_HUMAN No
VPS28_HUMAN No
WIT1_HUMAN No
XPA_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
ZC21C_HUMAN No
ZC3H1_HUMAN No
ZFHX3_HUMAN No
ZFY21_HUMAN No
ZGPAT_HUMAN No
ZMY19_HUMAN No
ZN250_HUMAN No
ZN414_HUMAN No
ZN417_HUMAN Yes: Q8TAU3 (MoonDB)
ZN446_HUMAN No
ZN572_HUMAN No
ZN580_HUMAN No
ZN581_HUMAN No
ZN587_HUMAN No
ZN833_HUMAN No
ZNF79_HUMAN No
PMID Article Title
1437549 RFP is a DNA binding protein associated with the nuclear matrix.
3037315 ret transforming gene encodes a fusion protein homologous to tyrosine kinases.
3380101 Developmentally regulated expression of a human 'finger'-containing gene encoded by the 5' half of the ret transforming gene.
9247190 Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution.
9570750 Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.
10504338 Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.
10976108 RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions.
11331580 The tripartite motif family identifies cell compartments.
12445133 Differential expression of RET finger protein in testicular germ cell tumors.
12787916 Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.
12807881 The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif.
14530259 Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.
14574404 The DNA sequence and analysis of human chromosome 6.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15837424 Selective ablation of retinoblastoma protein function by the RET finger protein.
17156811 Unique features of TRIM5alpha among closely related human TRIM family members.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20864041 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
22128329 Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2beta.
23452853 Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.
25320289 Identification of TRIM27 as a novel degradation target of Herpes Simplex Virus 1 ICP0.
No results found.
Domain Name Domain ID Source
TVHURF A28101 PIR
Znf_B-box IPR000315 InterPro
Znf_RING IPR001841 InterPro
B30.2/SPRY IPR001870 InterPro
SPRY_dom IPR003877 InterPro
Butyrophylin_SPRY IPR003879 InterPro
PRY IPR006574 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
ConA-like_dom_sf IPR013320 InterPro
Znf_RING_CS IPR017907 InterPro
Znf_B-box_chordata IPR020457 InterPro
SPRY/PRY_TRIM27 IPR035791 InterPro
SPRY PF00622 Pfam
zf-B_box PF00643 Pfam
PRY PF13765 Pfam
BBOXZNFINGER PR01406 PRINTS
BUTYPHLNCDUF PR01407 PRINTS
ZF_RING_1 PS00518 PROSITE
ZF_RING_2 PS50089 PROSITE
ZF_BBOX PS50119 PROSITE
B302_SPRY PS50188 PROSITE
RING SM00184 SMART
BBOX SM00336 SMART
SPRY SM00449 SMART
PRY SM00589 SMART
SSF49899 SSF49899 SUPFAM
BBOX cd00021 CDD
SPRY_PRY_TRIM27 cd15814 CDD