Protein: Q96HA8

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q96HA8 (Uniprot) NTAQ1_HUMAN WDYHV1 Protein N-terminal glutamine amidohydrolase human No
Uniprot: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 5 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
5 GO:0034645 cellular macromolecule biosynthetic process
5 GO:0006464 cellular protein modification process
5 GO:0090304 nucleic acid metabolic process
5 GO:0034654 nucleobase-containing compound biosynthetic process
5 GO:0060255 regulation of macromolecule metabolic process
57 GO:0006139 nucleobase-containing compound metabolic process
67 GO:0060255 regulation of macromolecule metabolic process
103 GO:0006139 nucleobase-containing compound metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
152 GO:0006139 nucleobase-containing compound metabolic process
385 GO:0090304 nucleic acid metabolic process
403 GO:0060255 regulation of macromolecule metabolic process
450 GO:0051252 regulation of RNA metabolic process
450 GO:0010646 regulation of cell communication
450 GO:2000112 regulation of cellular macromolecule biosynthetic process
450 GO:0010468 regulation of gene expression
450 GO:0023051 regulation of signaling
450 GO:0007165 signal transduction
596 GO:0006464 cellular protein modification process
605 GO:0007165 signal transduction
652 GO:0044267 cellular protein metabolic process
652 GO:0060255 regulation of macromolecule metabolic process
699 GO:0022607 cellular component assembly
699 GO:0051649 establishment of localization in cell
699 GO:0071705 nitrogen compound transport
699 GO:0008104 protein localization
699 GO:0019538 protein metabolic process
791 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
5 GO:0005829 cytosol
5 GO:0005634 nucleus
34 GO:0005634 nucleus
50 GO:0005829 cytosol
50 GO:0005634 nucleus
57 GO:0005634 nucleus
60 GO:0005634 nucleus
67 GO:0005634 nucleus
82 GO:0005634 nucleus
103 GO:0070013 intracellular organelle lumen
103 GO:0005634 nucleus
125 GO:0005829 cytosol
125 GO:0005634 nucleus
152 GO:0005829 cytosol
152 GO:0005634 nucleus
231 GO:0005634 nucleus
241 GO:0005829 cytosol
241 GO:0005634 nucleus
271 GO:0005634 nucleus
289 GO:0005634 nucleus
332 GO:0005634 nucleus
385 GO:0005634 nucleus
403 GO:0005634 nucleus
450 GO:0005634 nucleus
468 GO:0005634 nucleus
523 GO:0005829 cytosol
523 GO:0031982 vesicle
525 GO:0005829 cytosol
548 GO:0070013 intracellular organelle lumen
548 GO:0005634 nucleus
596 GO:0005634 nucleus
627 GO:0005634 nucleus
642 GO:0005634 nucleus
652 GO:0005829 cytosol
652 GO:0005634 nucleus
652 GO:0031982 vesicle
699 GO:0005829 cytosol
699 GO:0012505 endomembrane system
699 GO:0043232 intracellular non-membrane-bounded organelle
699 GO:0005634 nucleus
699 GO:0031982 vesicle
710 GO:0005829 cytosol
710 GO:0070013 intracellular organelle lumen
710 GO:0005634 nucleus
791 GO:0005634 nucleus
805 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006464 cellular protein modification process ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus ISS
GO:0005829 cytosol ISS
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
RBPMS_HUMAN Yes: Q93062 (MoonDB)
CRTP1_HUMAN No
KRA59_HUMAN No
KRA92_HUMAN No
TRAF1_HUMAN No
KR107_HUMAN No
G2XKQ0_HUMAN No
CEP70_HUMAN No
DAB1_HUMAN No
PR20D_HUMAN No
MDFI_HUMAN No
KRA33_HUMAN No
THAP1_HUMAN No
HSF2B_HUMAN No
CTG1B_HUMAN No
ZBED1_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
KAP1_HUMAN No
COIL_HUMAN No
GLYR1_HUMAN No
KLH12_HUMAN No
MTUS2_HUMAN No
NADE_HUMAN No
ATL4_HUMAN No
NECA2_HUMAN No
PNMA1_HUMAN No
ZBT8A_HUMAN No
TRI54_HUMAN No
KTBL1_HUMAN No
CARD9_HUMAN No
PAK5_HUMAN No
IKZF3_HUMAN No
VP37C_HUMAN Yes: A5D8V6 (MoonDB)
MAGAC_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
RBTN2_HUMAN No
LCE1D_HUMAN No
LCE5A_HUMAN No
KRA98_HUMAN No
A0A087WZT3_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
BIRC2_HUMAN No
BIRC7_HUMAN No
1433S_HUMAN No
5NT1A_HUMAN No
A0A0A0MR80_HUMAN No
AARD_HUMAN No
ACD_HUMAN Yes: Q96AP0 (MoonDB)
ACO13_HUMAN No
ACPM_HUMAN No
ACTB_HUMAN No
ACTG_HUMAN No
ACTN2_HUMAN No
ACY1_HUMAN No
AGR2_HUMAN No
AIMP2_HUMAN No
AKIR2_HUMAN No
AMOL2_HUMAN No
AMOT_HUMAN No
AMPD2_HUMAN No
AN36B_HUMAN No
ANM1_HUMAN No
ANM5_HUMAN No
AOC1_HUMAN No
AR6P1_HUMAN No
ARI4B_HUMAN No
ARLY_HUMAN No
BACD1_HUMAN No
BACD2_HUMAN No
BACD3_HUMAN No
BAFL_HUMAN No
BEND5_HUMAN No
BL1S6_HUMAN No
BLMH_HUMAN No
BORC6_HUMAN No
BPIB3_HUMAN No
BTBD1_HUMAN No
BTBD2_HUMAN No
C102B_HUMAN No
C170B_HUMAN No
C2AIL_HUMAN No
CA050_HUMAN No
CAN3_HUMAN No
CASP6_HUMAN No
CAVN4_HUMAN No
CBS_HUMAN No
CC184_HUMAN No
CC197_HUMAN No
CCHCR_HUMAN No
CD22_HUMAN No
CDD_HUMAN No
CDKA1_HUMAN No
CDR2_HUMAN No
CEP55_HUMAN No
CEP85_HUMAN No
CGBP1_HUMAN No
CGL_HUMAN No
CH10_HUMAN No
CHM4A_HUMAN No
CIP1_HUMAN No
CKLF5_HUMAN No
COAC_HUMAN No
COG6_HUMAN No
COLI_HUMAN No
CPSF5_HUMAN No
CRYAA_HUMAN Yes: P02489 (MoonDB)
CSK2B_HUMAN Yes: P67870 (MoonDB)
CT451_HUMAN No
CTBP1_HUMAN No
CTIP_HUMAN No
CUTC_HUMAN No
DCTP1_HUMAN No
DHB14_HUMAN No
DHYS_HUMAN No
DNAL4_HUMAN No
DX39B_HUMAN No
DYLT1_HUMAN No
DYN2_HUMAN Yes: P50570 (MoonDB)
EDAD_HUMAN No
EI2BA_HUMAN No
EPN3_HUMAN No
ETV6_HUMAN No
EXOS8_HUMAN No
FA72A_HUMAN No
FKBP6_HUMAN No
FRIH_HUMAN No
FRIL_HUMAN No
GAS7_HUMAN No
GBG3_HUMAN No
GFAP_HUMAN No
GG6L9_HUMAN No
GMCL1_HUMAN No
GMDS_HUMAN No
GNMT_HUMAN No
GO45_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
GPX7_HUMAN No
GRAM4_HUMAN No
GSTA4_HUMAN No
GSTO2_HUMAN No
GUSP1_HUMAN No
HAUS8_HUMAN No
HBAT_HUMAN No
HGD_HUMAN No
HIG1C_HUMAN No
HM20A_HUMAN No
HOME3_HUMAN No
HPRT_HUMAN No
HSPB6_HUMAN No
HUS1_HUMAN No
HXB6_HUMAN No
HYPM_HUMAN No
I4AY87_HUMAN No
INCA1_HUMAN No
ISCA2_HUMAN No
JKIP2_HUMAN No
K1C27_HUMAN No
K1H1_HUMAN No
KASH5_HUMAN No
KAZRN_HUMAN No
KCC2A_HUMAN No
KCD15_HUMAN No
KCD21_HUMAN No
KCNH1_HUMAN No
KCTD1_HUMAN No
KCTD4_HUMAN No
KCTD6_HUMAN No
KCTD7_HUMAN No
KCTD9_HUMAN No
KEAP1_HUMAN No
KI21B_HUMAN No
KLHL2_HUMAN No
KR105_HUMAN No
KR192_HUMAN No
KR196_HUMAN No
KRA31_HUMAN No
KRA42_HUMAN No
KRA94_HUMAN No
LCE1C_HUMAN No
LCE1E_HUMAN No
LCE1F_HUMAN No
LCE2C_HUMAN No
LDB2_HUMAN No
LEG2_HUMAN No
LMBL3_HUMAN No
LMO3_HUMAN No
LNX2_HUMAN Yes: Q8N448 (MoonDB)
LONF1_HUMAN No
LRC73_HUMAN No
LRIF1_HUMAN No
LZTL1_HUMAN No
LZTS1_HUMAN No
LZTS2_HUMAN No
MAGA2_HUMAN No
MAGAB_HUMAN Yes: P43364 (MoonDB)
MARHA_HUMAN No
MASU1_HUMAN No
MATN4_HUMAN No
MD1L1_HUMAN No
MED22_HUMAN No
MI4GD_HUMAN No
MIC19_HUMAN No
MIF_HUMAN No
MIO_HUMAN No
MIPO1_HUMAN No
MITD1_HUMAN No
MOB2_HUMAN No
MORN3_HUMAN No
MPLKI_HUMAN No
MR1L1_HUMAN No
MS18A_HUMAN No
MTD2L_HUMAN No
MTG8R_HUMAN No
MTNB_HUMAN No
MVP_HUMAN No
MYD88_HUMAN No
N4BP3_HUMAN No
NAB2_HUMAN No
NAGK_HUMAN No
NCOA5_HUMAN No
NDKA_HUMAN No
NO40_HUMAN No
NPL_HUMAN No
NUD14_HUMAN No
P5CR3_HUMAN No
PA2GX_HUMAN No
PCH2_HUMAN No
PFD5_HUMAN No
PGPI_HUMAN No
PHS_HUMAN Yes: P61457 (MoonDB)
PIHD2_HUMAN No
PKHB2_HUMAN No
PLAK_HUMAN No
PLCD1_HUMAN No
PNMA2_HUMAN No
PNMA5_HUMAN No
PPM1K_HUMAN No
PPR27_HUMAN No
PRAF1_HUMAN No
PRDC1_HUMAN No
PRPS2_HUMAN No
PSME3_HUMAN No
PTPS_HUMAN No
PYGM_HUMAN No
Q9BS75_HUMAN No
RAB42_HUMAN No
RAD54_HUMAN No
RASL3_HUMAN No
RBM45_HUMAN No
RBTN1_HUMAN No
REEP6_HUMAN No
RIPL1_HUMAN No
RN138_HUMAN No
ROP1A_HUMAN No
RPB11_HUMAN No
RPIA_HUMAN No
RUSC1_HUMAN No
S15A2_HUMAN No
SAP18_HUMAN No
SAT1_HUMAN No
SELV_HUMAN No
SEP14_HUMAN No
SEPT3_HUMAN No
SHLB2_HUMAN No
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
SIKE1_HUMAN No
SIVA_HUMAN No
SLAI1_HUMAN No
SMAP1_HUMAN No
SMN_HUMAN No
SNP29_HUMAN No
SPDE4_HUMAN No
SPERT_HUMAN No
SPT32_HUMAN No
SSNA1_HUMAN No
STF1_HUMAN No
STH_HUMAN No
STX11_HUMAN No
SYGP1_HUMAN No
SYSM_HUMAN No
T22D1_HUMAN No
TAXB1_HUMAN Yes: Q86VP1 (MoonDB)
TBX15_HUMAN No
TCAM2_HUMAN No
TCL1A_HUMAN No
TEKT1_HUMAN No
TENR_HUMAN No
TERA_HUMAN Yes: P55072 (MoonDB)
THAP6_HUMAN No
THAP7_HUMAN No
THG1_HUMAN No
TIFA_HUMAN No
TM239_HUMAN No
TNIP3_HUMAN No
TOLIP_HUMAN No
TRAF3_HUMAN Yes: Q13114 (MoonDB)
TRAF5_HUMAN No
TRI23_HUMAN No
TRI32_HUMAN No
TRI69_HUMAN No
TRI74_HUMAN No
TRIM5_HUMAN Yes: Q9C035 (MoonDB)
TRIM9_HUMAN No
TSNAX_HUMAN No
TSN_HUMAN No
UFC1_HUMAN No
UNKL_HUMAN No
VAC14_HUMAN No
VATG1_HUMAN No
VDR_HUMAN Yes: P11473 (MoonDB)
ZN165_HUMAN No
ZN341_HUMAN No
ZN436_HUMAN No
ZN618_HUMAN No
PMID Article Title
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16421571 DNA sequence and analysis of human chromosome 8.
No results found.
Domain Name Domain ID Source
Prot_N_Gln_amidohydro_ab_roll IPR023128 InterPro
N_Gln_amidohydro_ab_roll_sf IPR037132 InterPro
Nt_Gln_amidase PF09764 Pfam