Protein: Q13114

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q13114 (Uniprot) TRAF3_HUMAN TRAF3 TNF receptor-associated factor 3 human No
Uniprot: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 609 GO:0006725 cellular aromatic compound metabolic process 683 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
121 GO:0010467 gene expression
121 GO:0060255 regulation of macromolecule metabolic process
121 GO:0007165 signal transduction
131 GO:0070647 protein modification by small protein conjugation or removal
131 GO:0006355 regulation of transcription, DNA-templated
380 GO:0010467 gene expression
380 GO:0019538 protein metabolic process
380 GO:0060255 regulation of macromolecule metabolic process
420 GO:0006464 cellular protein modification process
476 GO:0010467 gene expression
476 GO:0060255 regulation of macromolecule metabolic process
487 GO:0006355 regulation of transcription, DNA-templated
511 GO:0010467 gene expression
511 GO:0051252 regulation of RNA metabolic process
569 GO:0007165 signal transduction
609 GO:0007166 cell surface receptor signaling pathway
609 GO:0006464 cellular protein modification process
609 GO:0071310 cellular response to organic substance
609 GO:0031325 positive regulation of cellular metabolic process
609 GO:0010604 positive regulation of macromolecule metabolic process
609 GO:0051173 positive regulation of nitrogen compound metabolic process
609 GO:0051246 regulation of protein metabolic process
609 GO:0006355 regulation of transcription, DNA-templated
683 GO:0006139 nucleobase-containing compound metabolic process
683 GO:0060255 regulation of macromolecule metabolic process
791 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
121 GO:0005634 nucleus
131 GO:0005829 cytosol
131 GO:0043232 intracellular non-membrane-bounded organelle
131 GO:0005634 nucleus
380 GO:0005634 nucleus
420 GO:0005829 cytosol
420 GO:0005634 nucleus
476 GO:0005634 nucleus
487 GO:0005634 nucleus
511 GO:0005634 nucleus
523 GO:0005829 cytosol
523 GO:0031982 vesicle
609 GO:0005829 cytosol
609 GO:0043232 intracellular non-membrane-bounded organelle
609 GO:0070013 intracellular organelle lumen
609 GO:0005634 nucleus
609 GO:0005886 plasma membrane
683 GO:0005829 cytosol
683 GO:0070013 intracellular organelle lumen
683 GO:0005634 nucleus
791 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001817 regulation of cytokine production ISS
GO:0002224 toll-like receptor signaling pathway ISS
GO:0006915 apoptotic process IEA
GO:0007165 signal transduction TAS
GO:0008063 Toll signaling pathway IEA
GO:0016567 protein ubiquitination IEA
GO:0016579 protein deubiquitination TAS
GO:0030162 regulation of proteolysis IMP
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
GO:0032480 negative regulation of type I interferon production TAS
GO:0032648 regulation of interferon-beta production ISS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0042981 regulation of apoptotic process IEA
GO:0045087 innate immune response IEA
GO:0050688 regulation of defense response to virus ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005739 mitochondrion IEA
GO:0005768 endosome IEA
GO:0005829 cytosol TAS
GO:0009898 cytoplasmic side of plasma membrane ISS
GO:0035631 CD40 receptor complex ISS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7527023 A novel RING finger protein interacts with the cytoplasmic domain of CD40.
7530216 A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.
7533327 Involvement of CRAF1, a relative of TRAF, in CD40 signaling.
7859281 The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.
8663299 TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.
8710854 I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
9162022 Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.
9168896 Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.
9275204 Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.
9418902 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.
9488716 Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.
9718306 CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.
9774460 The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
9774977 ASK1 is essential for JNK/SAPK activation by TRAF2.
10037686 Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.
10199393 A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation.
10523862 Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1).
10764746 TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
10791955 MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.
10809768 TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.
10903733 TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.
10984535 Molecular basis for CD40 signaling mediated by TRAF3.
11035039 The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.
12005438 Downstream regulator TANK binds to the CD40 recognition site on TRAF3.
12508121 The DNA sequence and analysis of human chromosome 14.
14517219 Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15084608 Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.
15383523 TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15585864 Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation.
16009714 LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3.
17991829 DUBA: a deubiquitinase that regulates type I interferon production.
19419966 The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.
19893624 The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
19937093 Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.
19996094 Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.
20097753 Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.
20174559 Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.
20185819 TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor.
20832341 Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.
21302310 Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23871208 The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
OMIM ID Disease Name
614849 Herpes simplex encephalitis 3
Domain Name Domain ID Source
A55960 A55960 PIR
Znf_TRAF IPR001293 InterPro
Znf_RING IPR001841 InterPro
MATH/TRAF_dom IPR002083 InterPro
TRAF-like IPR008974 InterPro
TNF_rcpt--assoc_TRAF IPR012227 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
Znf_RING_CS IPR017907 InterPro
TRAF3 IPR027128 InterPro
TRAF3_MATH IPR037304 InterPro
zf-TRAF PF02176 Pfam
TRAF PIRSF015614 PIRSF
ZF_RING_1 PS00518 PROSITE
ZF_RING_2 PS50089 PROSITE
MATH PS50144 PROSITE
ZF_TRAF PS50145 PROSITE
PTHR10131:SF76 PTHR10131:SF76 PANTHER
S68467 S68467 PIR
MATH SM00061 SMART
SSF49599 SSF49599 SUPFAM
MATH_TRAF3 cd03777 CDD