Protein: P02489

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P02489 (Uniprot) CRYAA_HUMAN CRYAA Alpha-crystallin A chain human Yes
Uniprot: Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Dissimilar Functions Manual Curation

Function 1: Molecular chaperone, protein folding.

Function 2: Structural protein of the lens, important for visual perception. Vertebrate crystallins resemble chaperones. Condition: eye lens localisation.

Publications (PMID): 1438232, 18587492, 14512969, 9467006, 6285380

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
88 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
88 GO:0012505 endomembrane system
88 GO:0031982 vesicle
289 GO:0005634 nucleus
525 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007601 visual perception IMP
GO:0032387 negative regulation of intracellular transport IDA
GO:0042026 protein refolding ISS
GO:0043066 negative regulation of apoptotic process IDA
GO:0050821 protein stabilization IMP
GO:0050896 response to stimulus IEA
GO:0051260 protein homooligomerization IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
PMID Article Title
817940 The amino acid sequence of the A chain of human alpha-crystallin.
1730617 Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine.
2918909 A pseudo-exon in the functional human alpha A-crystallin gene.
3758227 Isolation and partial characterization of the human alpha A-crystallin gene.
8175657 Post-translational modifications of water-soluble human lens crystallins from young adults.
8587135 A reassessment of mammalian alpha A-crystallin sequences using DNA sequencing: implications for anthropoid affinities of tarsier.
8759518 Differential phosphorylation of alpha-A crystallin in human lens of different age.
8943244 Cloning, expression, and chaperone-like activity of human alphaA-crystallin.
8999933 Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.
9068373 Modifications of the water-insoluble human lens alpha-crystallins.
9467006 Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA.
9543632 Quantitation of asparagine-101 deamidation from alpha-A crystallin during aging of the human lens.
9655350 In vivo acetylation identified at lysine 70 of human lens alphaA-crystallin.
10830953 The DNA sequence of human chromosome 21.
10930324 The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage.
11123904 Structural and functional changes in the alpha A-crystallin R116C mutant in hereditary cataracts.
12356833 Enhanced C-terminal truncation of alphaA- and alphaB-crystallins in diabetic lenses.
12369933 Chaperone-like activity of alpha-crystallin and other small heat shock proteins.
14512969 Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16453125 Congenital cataract and macular hypoplasia in humans associated with a de novo mutation in CRYAA and compound heterozygous mutations in P.
16959974 The consensus coding sequences of human breast and colorectal cancers.
17909943 C-Terminal truncation affects subunit exchange of human alphaA-crystallin with alphaB-crystallin.
18302245 Clinical variability of autosomal dominant cataract, microcornea and corneal opacity and novel mutation in the alpha A crystallin gene (CRYAA).
18407550 A novel mutation in AlphaA-crystallin (CRYAA) caused autosomal dominant congenital cataract in a large Chinese family.
18754677 Structural and functional roles of deamidation and/or truncation of N- or C-termini in human alpha A-crystallin.
19464326 HSPB7 is a SC35 speckle resident small heat shock protein.
20836128 Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications.
22120592 Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function.
22890888 Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry.
23508780 Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes.
OMIM ID Disease Name
604219 Cataract 9, multiple types
Domain Name Domain ID Source
Alpha-crystallin/HSP IPR001436 InterPro
A-crystallin/Hsp20_dom IPR002068 InterPro
Alpha-crystallin_N IPR003090 InterPro
HSP20-like_chaperone IPR008978 InterPro
Alpha-crystallin_A IPR012274 InterPro
HSP20 IPR031107 InterPro
HSP20 PF00011 Pfam
Crystallin PF00525 Pfam
Sm_HSP_B1 PIRSF036514 PIRSF
ACRYSTALLIN PR00299 PRINTS
SHSP PS01031 PROSITE
PTHR11527 PTHR11527 PANTHER
PTHR11527:SF36 PTHR11527:SF36 PANTHER
CYHUAA S03344 PIR
SSF49764 SSF49764 SUPFAM