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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: P43364
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P43364 (Uniprot)
MAGAB_HUMAN
MAGEA11
Melanoma-associated antigen 11
human
No
Protein Function
Uniprot:
Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006725
cellular aromatic compound metabolic process
103
GO:0051641
cellular localization
872
2.74e-17
6.15e-158
GO:0006139
nucleobase-containing compound metabolic process
497
,
616
GO:0051641
cellular localization
872
4.17e-16
1.54e-157
GO:0009059
macromolecule biosynthetic process
662
GO:0051641
cellular localization
872
1.95e-13
6.68e-127
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
99
GO:0031325
positive regulation of cellular metabolic process
99
GO:0010628
positive regulation of gene expression
99
GO:0051173
positive regulation of nitrogen compound metabolic process
99
GO:0019538
protein metabolic process
99
GO:0006357
regulation of transcription from RNA polymerase II promoter
99
GO:0007165
signal transduction
103
GO:0006139
nucleobase-containing compound metabolic process
497
GO:0090304
nucleic acid metabolic process
497
GO:0060255
regulation of macromolecule metabolic process
547
GO:0060255
regulation of macromolecule metabolic process
616
GO:0090304
nucleic acid metabolic process
622
GO:0007165
signal transduction
643
GO:0044267
cellular protein metabolic process
662
GO:0034645
cellular macromolecule biosynthetic process
662
GO:0044271
cellular nitrogen compound biosynthetic process
662
GO:0090304
nucleic acid metabolic process
826
GO:0022607
cellular component assembly
826
GO:0044267
cellular protein metabolic process
872
GO:0051649
establishment of localization in cell
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
82
GO:0005634
nucleus
99
GO:0005654
nucleoplasm
103
GO:0070013
intracellular organelle lumen
103
GO:0005634
nucleus
224
GO:0070013
intracellular organelle lumen
224
GO:0005634
nucleus
231
GO:0005634
nucleus
497
GO:0005634
nucleus
538
GO:0043232
intracellular non-membrane-bounded organelle
547
GO:0005654
nucleoplasm
616
GO:0005654
nucleoplasm
622
GO:0005829
cytosol
622
GO:0070013
intracellular organelle lumen
622
GO:0005634
nucleus
627
GO:0005634
nucleus
635
GO:0043232
intracellular non-membrane-bounded organelle
635
GO:0031981
nuclear lumen
641
GO:0005634
nucleus
643
GO:0005634
nucleus
662
GO:0043232
intracellular non-membrane-bounded organelle
662
GO:0005634
nucleus
826
GO:0005829
cytosol
826
GO:0005634
nucleus
872
GO:0005829
cytosol
Protein GO Annotations
Biological Processes
No results found.
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005654
nucleoplasm
IDA
GO:0005829
cytosol
IDA
GO:0016604
nuclear body
IDA
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
TPM3_HUMAN
No
TRI27_HUMAN
Yes:
P14373 (MoonDB)
BIRC2_HUMAN
No
NTAQ1_HUMAN
Yes:
Q96HA8 (MoonDB)
CEP76_HUMAN
No
CSK21_HUMAN
Yes:
P68400 (MoonDB)
TCEA2_HUMAN
No
TEANC_HUMAN
No
SH24A_HUMAN
No
IL6RB_HUMAN
No
NIF3L_HUMAN
No
TEX37_HUMAN
No
ZBT16_HUMAN
Yes:
Q05516 (MoonDB)
SUOX_HUMAN
No
THIOM_HUMAN
No
CC146_HUMAN
No
COR1A_HUMAN
No
F161A_HUMAN
No
LNX1_HUMAN
Yes:
Q8TBB1 (MoonDB)
MCRS1_HUMAN
No
BEX2_HUMAN
No
HXB5_HUMAN
No
CC185_HUMAN
No
G45IP_HUMAN
No
ILF3_HUMAN
No
PAHX_HUMAN
No
CAVN3_HUMAN
No
ACMSD_HUMAN
No
ACO15_HUMAN
No
ACS2B_HUMAN
No
ACTN1_HUMAN
No
AK1C3_HUMAN
No
ANDR_HUMAN
Yes:
P10275 (MoonDB)
B2L11_HUMAN
No
BRD1_HUMAN
No
CASP7_HUMAN
No
CATL3_HUMAN
No
CC105_HUMAN
No
CC106_HUMAN
No
CCD14_HUMAN
No
CCD27_HUMAN
No
CD20B_HUMAN
No
CDN2B_HUMAN
No
CIA30_HUMAN
No
CLUA1_HUMAN
No
COX7R_HUMAN
No
CS060_HUMAN
No
CTTB2_HUMAN
No
CV039_HUMAN
No
DIEXF_HUMAN
No
DJC10_HUMAN
No
DLGP1_HUMAN
No
DOC10_HUMAN
No
EGLN1_HUMAN
No
ENOX2_HUMAN
No
EWS_HUMAN
No
FA156_HUMAN
No
FL2D_HUMAN
No
GCSH_HUMAN
No
GLCM_HUMAN
No
GNPI1_HUMAN
No
IFI44_HUMAN
No
IL11_HUMAN
No
JADE3_HUMAN
No
K0408_HUMAN
No
LAS2_HUMAN
No
MAD3_HUMAN
No
MED28_HUMAN
No
MGME1_HUMAN
No
MLF1_HUMAN
Yes:
P58340 (MoonDB)
MTA1_HUMAN
No
MYOZ1_HUMAN
No
NCOA2_HUMAN
No
NDEL1_HUMAN
Yes:
Q9GZM8 (MoonDB)
NDUB9_HUMAN
No
NOL4_HUMAN
No
NOS3_HUMAN
No
NSUN4_HUMAN
No
OTUB2_HUMAN
No
P3IP1_HUMAN
No
PDE4B_HUMAN
No
PHS2_HUMAN
No
PIN4_HUMAN
No
PKRI1_HUMAN
No
PLCX3_HUMAN
No
PNKD_HUMAN
No
PNKP_HUMAN
No
PORIM_HUMAN
No
PPIF_HUMAN
No
PPM1K_HUMAN
No
PRDX3_HUMAN
No
PSMF1_HUMAN
No
Q9NXX0_HUMAN
No
RADIL_HUMAN
No
RBM23_HUMAN
No
RBP10_HUMAN
No
RHG29_HUMAN
No
RPAC2_HUMAN
No
SNX20_HUMAN
No
SNX7_HUMAN
No
SSDH_HUMAN
No
STAR_HUMAN
No
SUCB1_HUMAN
No
TCF25_HUMAN
No
TRI51_HUMAN
No
TRM1_HUMAN
No
UB2D4_HUMAN
Yes:
Q9Y2X8 (MoonDB)
UBE3D_HUMAN
No
UBP20_HUMAN
No
VTA1_HUMAN
No
ZCH12_HUMAN
No
ZN655_HUMAN
No
ZNF98_HUMAN
No
ZSWM2_HUMAN
No
Publications Associated
PMID
Article Title
7927540
Structure, chromosomal localization, and expression of 12 genes of the MAGE family.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15684378
Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
I38660
I38660
PIR
MHD_dom
IPR002190
InterPro
MAGE_N
IPR021072
InterPro
MAGEA11
IPR030099
InterPro
MAGE
IPR037445
InterPro
MAGE
PF01454
Pfam
MAGE_N
PF12440
Pfam
MAGE
PS50838
PROSITE
PTHR11736
PTHR11736
PANTHER
PTHR11736:SF71
PTHR11736:SF71
PANTHER
MAGE
SM01373
SMART
MAGE_N
SM01392
SMART