Protein: Q9GZM8

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9GZM8 (Uniprot) NDEL1_HUMAN NDEL1 Nuclear distribution protein nudE-like 1 human No
Uniprot: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 127 GO:0051641 cellular localization 872 4.50e-03 3.02e-89
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 353 GO:0019538 protein metabolic process 393 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
36 GO:0022607 cellular component assembly
67 GO:0060255 regulation of macromolecule metabolic process
127 GO:0016070 RNA metabolic process
127 GO:0010467 gene expression
223 GO:0022607 cellular component assembly
223 GO:0007165 signal transduction
319 GO:0060255 regulation of macromolecule metabolic process
353 GO:0000398 mRNA splicing, via spliceosome
393 GO:0044267 cellular protein metabolic process
826 GO:0022607 cellular component assembly
826 GO:0044267 cellular protein metabolic process
872 GO:0051649 establishment of localization in cell
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
36 GO:0005829 cytosol
36 GO:0005815 microtubule organizing center
67 GO:0005634 nucleus
84 GO:0005634 nucleus
95 GO:0005634 nucleus
127 GO:0005634 nucleus
223 GO:0005634 nucleus
232 GO:0005829 cytosol
232 GO:0043232 intracellular non-membrane-bounded organelle
319 GO:0005829 cytosol
319 GO:0005634 nucleus
353 GO:0005654 nucleoplasm
393 GO:0043232 intracellular non-membrane-bounded organelle
393 GO:0005634 nucleus
812 GO:0005634 nucleus
826 GO:0005829 cytosol
826 GO:0005634 nucleus
872 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000132 establishment of mitotic spindle orientation IBA
GO:0001764 neuron migration IEA
GO:0001833 inner cell mass cell proliferation IEA
GO:0006508 proteolysis IEA
GO:0007020 microtubule nucleation IBA
GO:0007059 chromosome segregation IMP
GO:0007062 sister chromatid cohesion TAS
GO:0007100 mitotic centrosome separation IBA
GO:0008090 retrograde axonal transport IEA
GO:0008286 insulin receptor signaling pathway IEA
GO:0010975 regulation of neuron projection development IBA
GO:0016477 cell migration IBA
GO:0021799 cerebral cortex radially oriented cell migration IEA
GO:0021955 central nervous system neuron axonogenesis IEA
GO:0032418 lysosome localization ISS
GO:0033157 regulation of intracellular protein transport IMP
GO:0043547 positive regulation of GTPase activity IMP
GO:0045773 positive regulation of axon extension IEA
GO:0047496 vesicle transport along microtubule IBA
GO:0048680 positive regulation of axon regeneration IEA
GO:0051081 nuclear envelope disassembly IEA
GO:0051303 establishment of chromosome localization IBA
GO:0051642 centrosome localization IBA
GO:0060052 neurofilament cytoskeleton organization IEA
GO:0090630 activation of GTPase activity IEA
GO:1900029 positive regulation of ruffle assembly ISS
GO:1990138 neuron projection extension IEA
GO:2000574 regulation of microtubule motor activity IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000776 kinetochore IDA
GO:0000777 condensed chromosome kinetochore IEA
GO:0005635 nuclear envelope IEA
GO:0005813 centrosome IBA
GO:0005819 spindle IEA
GO:0005829 cytosol TAS
GO:0005871 kinesin complex IBA
GO:0005874 microtubule IEA
GO:0008021 synaptic vesicle IEA
GO:0031252 cell leading edge IEA
GO:0043203 axon hillock IEA
GO:0060053 neurofilament cytoskeleton IEA
GO:0090724 central region of growth cone IEA
GO:1904115 axon cytoplasm IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
11163260 NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein.
12506198 Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.
12556484 Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.
12812986 DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14962739 Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
14970193 Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15572112 Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.
15728732 Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.
16005531 Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation.
16203747 Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.
16291865 Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
16682949 Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation.
17035248 DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.
17600710 Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19927128 Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
NUDE_dom IPR006964 InterPro
NDEL1 IPR033493 InterPro
NUDE IPR033494 InterPro
NUDE_C PF04880 Pfam
PTHR10921 PTHR10921 PANTHER
PTHR10921:SF0 PTHR10921:SF0 PANTHER