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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P58340
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P58340 (Uniprot)
MLF1_HUMAN
MLF1
Myeloid leukemia factor 1
human
No
Protein Function
Uniprot:
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses R
FWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
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MoonDB Dissimilar Functions
Showing 1 to 2 of 2 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0007165
signal transduction
1
,
534
GO:0006725
cellular aromatic compound metabolic process
395
5.44e-126
5.27e-27
GO:0007165
signal transduction
1
,
534
GO:0006139
nucleobase-containing compound metabolic process
616
1.10e-111
5.07e-25
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 72 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1
GO:0035556
intracellular signal transduction
1
GO:0032268
regulation of cellular protein metabolic process
1
GO:0043067
regulation of programmed cell death
1
GO:0009966
regulation of signal transduction
24
GO:0016070
RNA metabolic process
24
GO:0006464
cellular protein modification process
24
GO:0034654
nucleobase-containing compound biosynthetic process
24
GO:0006796
phosphate-containing compound metabolic process
24
GO:0031325
positive regulation of cellular metabolic process
24
GO:0010604
positive regulation of macromolecule metabolic process
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Cellular Components
Showing 1 to 10 of 41 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
1
GO:0005829
cytosol
1
GO:0005634
nucleus
24
GO:0005829
cytosol
24
GO:0005654
nucleoplasm
155
GO:0005634
nucleus
157
GO:0005654
nucleoplasm
162
GO:0005634
nucleus
192
GO:0005829
cytosol
192
GO:0005654
nucleoplasm
211
GO:0005829
cytosol
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Protein GO Annotations
Biological Processes
Showing 1 to 3 of 3 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0002318
myeloid progenitor cell differentiation
ISS
GO:0006351
transcription, DNA-templated
ISS
GO:0007050
cell cycle arrest
IDA
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
IDA
GO:0005737
cytoplasm
ISS
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 85 entries
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Interactor
Also a MoonDB EMF protein
1433E_HUMAN
Yes:
P62258 (MoonDB)
AASD1_HUMAN
No
B4DE84_HUMAN
No
BAG1_HUMAN
No
BAG2_HUMAN
No
BAG3_HUMAN
No
BRCA1_HUMAN
No
CACP_HUMAN
No
CALCR_HUMAN
No
CALU_HUMAN
No
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Publications Associated
Showing 1 to 8 of 8 entries
Search:
PMID
Article Title
8570204
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15116101
cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15861129
Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.
16641997
The DNA sequence, annotation and analysis of human chromosome 3.
22151054
Structural insights of the MLF1/14-3-3 interaction.
23186163
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 3 of 3 entries
Search:
Domain Name
Domain ID
Source
Mlf1IP
PF10248
Pfam
Myeloid_leukemia_factor
IPR019376
InterPro
PTHR13105
PTHR13105
PANTHER
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