Protein: P58340 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P58340 (Uniprot)	MLF1_HUMAN	MLF1	Myeloid leukemia factor 1	human	No

Protein Function

Uniprot: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses R more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	1, 534	GO:0006725	cellular aromatic compound metabolic process	395	5.44e-126	5.27e-27
GO:0007165	signal transduction	1, 534	GO:0006139	nucleobase-containing compound metabolic process	616	1.10e-111	5.07e-25

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1	GO:0035556	intracellular signal transduction
1	GO:0032268	regulation of cellular protein metabolic process
1	GO:0043067	regulation of programmed cell death
1	GO:0009966	regulation of signal transduction
24	GO:0016070	RNA metabolic process
24	GO:0006464	cellular protein modification process
24	GO:0034654	nucleobase-containing compound biosynthetic process
24	GO:0006796	phosphate-containing compound metabolic process
24	GO:0031325	positive regulation of cellular metabolic process
24	GO:0010604	positive regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1	GO:0005829	cytosol
1	GO:0005634	nucleus
24	GO:0005829	cytosol
24	GO:0005654	nucleoplasm
155	GO:0005634	nucleus
157	GO:0005654	nucleoplasm
162	GO:0005634	nucleus
192	GO:0005829	cytosol
192	GO:0005654	nucleoplasm
211	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002318	myeloid progenitor cell differentiation	ISS
GO:0006351	transcription, DNA-templated	ISS
GO:0007050	cell cycle arrest	IDA

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	ISS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 85 entries

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Interactor	Also a MoonDB EMF protein
1433E_HUMAN	Yes: P62258 (MoonDB)
AASD1_HUMAN	No
B4DE84_HUMAN	No
BAG1_HUMAN	No
BAG2_HUMAN	No
BAG3_HUMAN	No
BRCA1_HUMAN	No
CACP_HUMAN	No
CALCR_HUMAN	No
CALU_HUMAN	No

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Publications Associated

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PMID	Article Title
8570204	The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15116101	cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15861129	Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.
16641997	The DNA sequence, annotation and analysis of human chromosome 3.
22151054	Structural insights of the MLF1/14-3-3 interaction.
23186163	Toward a comprehensive characterization of a human cancer cell phosphoproteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 3 of 3 entries

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Domain Name	Domain ID	Source
Mlf1IP	PF10248	Pfam
Myeloid_leukemia_factor	IPR019376	InterPro
PTHR13105	PTHR13105	PANTHER

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