Protein: Q13200 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q13200 (Uniprot)	PSMD2_HUMAN	PSMD2	26S proteasome non-ATPase regulatory subunit 2	human	No

Protein Function

Uniprot: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose func more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	1	GO:0006725	cellular aromatic compound metabolic process	345	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1	GO:0035556	intracellular signal transduction
1	GO:0032268	regulation of cellular protein metabolic process
1	GO:0043067	regulation of programmed cell death
1	GO:0009966	regulation of signal transduction
24	GO:0016070	RNA metabolic process
24	GO:0006464	cellular protein modification process
24	GO:0034654	nucleobase-containing compound biosynthetic process
24	GO:0006796	phosphate-containing compound metabolic process
24	GO:0031325	positive regulation of cellular metabolic process
24	GO:0010604	positive regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1	GO:0005829	cytosol
1	GO:0005634	nucleus
24	GO:0005829	cytosol
24	GO:0005654	nucleoplasm
155	GO:0005634	nucleus
157	GO:0005654	nucleoplasm
162	GO:0005634	nucleus
283	GO:0012505	endomembrane system
283	GO:0044428	nuclear part
291	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000165	MAPK cascade	TAS
GO:0000209	protein polyubiquitination	TAS
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0006521	regulation of cellular amino acid metabolic process	TAS
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016579	protein deubiquitination	TAS
GO:0031145	anaphase-promoting complex-dependent catabolic process	TAS
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS
GO:0033209	tumor necrosis factor-mediated signaling pathway	TAS

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Cellular Components

Showing 1 to 10 of 13 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000502	proteasome complex	IDA
GO:0005576	extracellular region	TAS
GO:0005634	nucleus	IBA
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	TAS
GO:0005838	proteasome regulatory particle	TAS
GO:0008540	proteasome regulatory particle, base subcomplex	IBA
GO:0016020	membrane	IDA
GO:0022624	proteasome accessory complex	ISS
GO:0034515	proteasome storage granule	IBA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005576	extracellular region	GO:0005654	nucleoplasm	6.62e-72	7.68e-98
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0016020	membrane	5.76e-255	1.32e-206
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AASD1_HUMAN	No
ADA2A_HUMAN	No
AGO2_HUMAN	No
AP3D1_HUMAN	No
B4DE84_HUMAN	No
BAG1_HUMAN	No
BAG2_HUMAN	No
BAG3_HUMAN	No
BAG5_HUMAN	No
CDK9_HUMAN	No

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Publications Associated

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PMID	Article Title
1317798	Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.
7601280	A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'.
8774743	cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
9126987	Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16641997	The DNA sequence, annotation and analysis of human chromosome 3.
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17323924	Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
17924679	Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

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Domain Name	Domain ID	Source
26S_Psome_Rpn1	IPR016643	InterPro
26S_Psome_Rpn1	PIRSF015965	PIRSF
ARM-like	IPR011989	InterPro
ARM-type_fold	IPR016024	InterPro
PC_rep	PF01851	Pfam
Proteasome/cyclosome_rpt	IPR002015	InterPro
PTHR10943:SF1	PTHR10943:SF1	PANTHER
SSF48371	SSF48371	SUPFAM

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